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Biomedical subjects

G Lejeune

Publications and source records attributed to G Lejeune.

At least 37 records · Page 2Linked to original sources

Plasmacytoma of the thyroid: a case report, a study with use of the immunoperoxidase technique, and a review of the literature.

A case of solitary plasmacytoma of the thyroid is reported. A monoclonal component (IgG lambda) was identified in the serum of the patient and disappeared after total thyroidectomy and radiotherapy. The use of the immunoperoxidase technique on thyroid, bone marrow, and lymph node specimens allowed us to demonstrate the production of IgG lambda by the tumor, and to rule out the possibility of multiple myeloma. Previously reported cases are reviewed (15 cases). The diagnostic criteria, the association with thyroiditis, and the treatment of this rare disorder are discussed.

Bone Marrow↗

Intrinsic fasciotomy. When and why?

Major trauma to the upper extremity may lead to ischemic contracture of various muscle groups, sometimes including the intrinsic muscles of the hand. The clinical consequence of such necrotic fibrosis of the intrinsics is clawing of the digits with marked stiffness. After a short anatomical review of the fascias of the intrinsics, indications and operative techniques are discussed, in parallel with clinical cases. Intrinsic fasciotomy thus appears to be a major step in the prevention of digital clawing, when associated with early physiotherapy.

Amputation, Traumatic↗

[Immunogenicity of nerve allografts in rats].

The state of sensitization of rats after nerve or skin allograft was studied in vitro by using spleen cells or peripheral blood leukocytes (PBL) as responding cells and particulate alloantigen for stimulation, in culture conditions requiring or not supernatant from mixed lymphocytes culture. It is shown that 2-4 weeks after nerve or skin grafting a small number of PBL generates similar cytotoxic lymphocytic responses. However the state of sensitization induced by the nerve allografts is shorter compared to the one exhibited after skin allografts. On the other hand, no significant differences were observed at the level of the humoral response between both groups of grafted rats.

Animals↗