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Biomedical subjects

G Lecatsas

Publications and source records attributed to G Lecatsas.

At least 37 records · Page 2Linked to original sources
PubMed1991

Human T-lymphotropic virus type I-associated myelopathy. A case report.

Tropical spastic paraparesis (TSP) has been reported from various parts of the world for several decades. Recently reports have emerged from Japan and also countries in tropical zones associating endemic TSP with abnormally high titres of antibodies to human T-lymphotropic virus type I (HTLV-I). Data indicate that this lymphotropic retrovirus is neuropathogenic, either by direct invasion or via immunopathological mechanisms. A South African man is described who met the diagnostic criteria of TSP. Both serum and cerebrospinal fluid were antibody-positive for HTLV-I. It is possible that HTLV-I infection may be implicated in the 'myelopathies of undetermined cause' that form a substantial subgroup of spinal cord disease occurring in black South Africans.

Adult↗
PubMed1991

Origin of AIDS.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Successive urinary papillomavirus excretion, condylomata acuminata and urogenital epithelial malignant disease after renal transplantation.

Of 3 renal allograft recipients who were found to excrete papillomavirus in the urine, 1 has since developed a condyloma, 1 a condyloma and a keratinizing squamous carcinoma and 1 a transitional cell carcinoma. Peroxidase-antiperoxidase staining has confirmed the presence of papillomavirus antigen in the condylomas. The significance of these findings is discussed.

Adult↗
PubMed1985

Bacteriophage D: an IncD group plasmid-specific phage.

The existence of the plasmid incompatibility group D was reaffirmed as a result of compatibility experiments done on plasmids R687, R711b, R778b and R840 which were previously tentatively accepted as constituting the group. The group was further delineated by the isolation of a phage, phage D, which adsorbed specifically to IncD plasmid-encoded pili produced by Escherichia coli K12 strains and strains of Salmonella typhimurium, Proteus morganii and Klebsiella oxytoca harbouring one of these plasmids. Plaque formation, like that of phage pilH alpha, was temperature sensitive in that plaques formed at 26 degrees C but not at 37 degrees C. Plaques were fairly clear, regular in outline and varied from pinpoint to about 1.5 mm in diameter on E. coli hosts where plaques were detected, but on the other hosts the plaques were more turbid and often irregular in outline. The phage did not plate (or propagate) on IncD plasmid-carrying strains of Providencia alcalifaciens, Providencia stuartii or Serratia marcescens. The phage had an isometric hexagonal outline with a diameter of about 27 nm. It contained RNA and resembled two other RNA-containing phages, M and pilH alpha, by being sensitive to chloroform. It adsorbed to the sides of the very distal ends of the shafts of IncD plasmid-coded pili.

Conjugation, Genetic↗
PubMed1985

Characterization of phages derived from strains of Rhodococcus australis and R. equii.

Rhodococcus australis strain CSIR-A201 and R. equii strain CSIR-A655 spontaneously liberated phages A and B, respectively. The phages have different host ranges, but both infect R. rubropertinctus ATCC 14352. phage infection of strains resulted in stable lysogeny. The phages have similar morphologies and belong to the family Styloviridae. The DNA restriction enzyme patterns of the phages differ and do not correspond to those of actinophage phi EC. These temperate phages did not transduce prototrophic or antibiotic resistance markers to appropriate hosts.

Actinomycetales↗
PubMed1984

Genome analysis of BK (WW) viral DNA cloned directly from human urine.

DNA from a third isolate of the WW strain of BK virus was prepared from human urine and was cloned into the BamHI site of pBR322. Restriction mapping showed a number of changes relative to the prototype BK viral DNA, including the presence of a new PstI, an SstI, and an AvaII site and the loss of a HindIII, an SstI, and an NcoI site. There is evidence for more extensive changes in the vicinity of the origin of replication.

BK Virus↗
PubMed1984

Transmission of simian acquired immunodeficiency syndrome (SAIDS) with type D retrovirus isolated from saliva or urine.

Saliva and urine specimens from rhesus monkeys with SAIDS were found to contain a type D retrovirus related to Mason-Pfizer monkey virus (MPMV) which has been linked etiologically to SAIDS. Virus isolates from saliva and urine were shown to have the characteristics of the SAIDS agent by their reverse transcriptase divalent cation preference for synthetic template-primers, production of characteristic cytopathology in Raji cells and antigenic relatedness to MPMV as determined by enzyme-linked immunosorbent assay (ELISA) and competition radioimmunoassay (RIA). Electron micrographs of parotid tissue from an animal with SAIDS also showed budding particles with type D retrovirus morphology. A tissue culture grown virus isolate from urine of an animal with SAIDS, produced SAIDS when inoculated into two normal juvenile rhesus monkeys. Since saliva and urine of monkeys with SAIDS contain infectious SAIDS virus, they are likely sources of virus by which the disease is naturally transmitted. Thus, care should be taken to avoid contact of normal and infected animals.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Morphology of the retroviruses associated with AIDS and SAIDS.

Thin section electron microscopy of tissue culture preparations of viruses associated with AIDS and SAIDS have shown that the mature particles have a similar morphology following budding from the cell membrane. The model provided explains the various core morphologies seen in section and provides a basis for identifying these agents in clinical tissues.

Acquired Immunodeficiency Syndrome↗