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Biomedical subjects

G Laurora

Publications and source records attributed to G Laurora.

80 records · Page 5Linked to original sources
PubMedDate not supplied

[Progression of lesions of the arterial wall evaluated by ultrasonic biopsy in asymptomatic subjects and in diabetic and hyperlipidemic patients treated with bezafibrate. A 4-year follow-up].

Non-invasive arterial ultrasonic biopsy (UB) has been used to evaluate and follow-up arterial wall changes in four years in asymptomatic subjects, hyperlipidemics and diabetics. Both groups of patients were randomised in a treatment group (bezafibrate 400 mg daily) and in a control group. The rate of progression (ROP) into the next higher UB class was recorded by UB scans repeated every six months. In diabetics and hyperlipidemics the rate of progression (ROP, namely the percent of patients progressing to the next class) was significantly higher than the ROP in the asymptomatic subjects. However in the bezafibrate group the ROP was significantly lower than that observed in the controls. As each UB class corresponds to different levels of risks of occult coronary ischemia and cardiovascular events in the following four years, the reduction of ROP with bezafibrate was an important and positive achievement.

Adult↗
PubMedDate not supplied

[Vascular reactivity related to postural changes in diabetics].

Resting skin flow (RF) and the venoarteriolar response (VAR) were studied in 40 patients with diabetic microangiopathy and neuropathy, in 40 diabetes with microangiopathy and in 30 normal subjects using laser-Doppler flowmetry. In patients with microangiopathy and neuropathy RF was increased and the VAR was impaired to a greater extent than in patients without neuropathy. We evaluated the microangiopathy index (VAR/RF) that was lower in diabetics without neuropathy and even lower in those with neuropathy than in normals We also evaluated the VAR with different postural changes.

Adult↗
PubMedDate not supplied

Laser-Doppler flowmetry in the assessment of "mild" Raynaud's phenomenon and its treatment.

Raynaud's phenomenon is characterised by a reduction in skin temperature and blood flow. Laser-Doppler Flowmetry (LDF) has been used to evaluate LDF recovery time after immersion of hands in water at 20 degrees C for 1 minute before and after treatment. After treatment for 4 weeks with nifedipine 10 mg b.i.d. the recovery time was again measured. The study showed that the treatment is useful for normalising the recovery times and reducing symptoms.

Adult↗
PubMedDate not supplied

Clinical evaluation of defibrotide in the treatment of arterial and venous vascular disease. A preliminary report.

Defibrotide is a new compound with antithrombotic and profibrinolytic activity. It increases the endogenous fibrinolytic activity by promoting the cellular activator of plasminogen from endothelial cells and by decreasing the concentration of its inhibitors. In this study we evaluated a total of 223 patients for a mean period of 43 days for the following vascular conditions: (a) superficial venous thrombosis; (b) prophylaxis against deep venous thrombosis; (c) peripheral vascular disease (ischaemic foot and intermittent claudication; (d) prophylaxis against TIAs in patients with carotid plaques determining embolization; (e) treatment of venous ulcerations determined by chronic venous incompetence; (f) patients with Raynaud's phenomenon and disease. The tolerability observed was good. No side effects were observed even in more prolonged treatments. The overall efficacy was good for all groups especially in comparison with other treatment already in use for these vascular conditions. In conclusion defibrotide is a particularly useful drug in these vascular diseases and can be used both for acute and chronic treatments.

Adult↗
PubMedDate not supplied

Evaluation of cerebral blood flow in premature newborns by duplex scanning using a high resolution probe.

The evaluation of cerebral blood flow in premature newborns offers interesting information about cerebral circulation and, physiological flow variations. Using a high resolution probe as the Access 10 of the ATL ultramark 4 duplex scanner it was possible to define flow in the anterior cerebral artery and in the middle cerebral artery in newborns without significant pathology. This study was performed in premature babies both to evaluate the best technical solution to study these small arteries and to define a standard of flow to be used in future evaluations. By the 10 MHz focus (on the variable focus probe 5-7.5 and 10 MHz) it was observed that a smaller variation of flow determinations is obtained by the 10 MHz focus (both for the middle and anterior cerebral arteries). In conclusion duplex scanning offers probably the best solution to evaluate cerebral blood flow in premature newborns both in qualitative and quantitative way.

Cerebral Arteries↗
PubMedDate not supplied

Evaluation of flow in nodular tumors of the breast by Doppler and duplex scanning.

Evaluation of flow in nodular tumors of the breast may be performed by Doppler and computerized frequency analysis. In 46 nodules of the breast (22 malignant) the nodular flow velocity and frequency analysis revealed a faster flow with a significantly higher peak frequency and mean velocity. The intensity of sound which may be considered an index of the entity of flow in the nodule was larger than that observed in the normal surrounding breast tissue. In malignant nodules and generally in fast growing nodules the flow velocity and intensity was even larger. The flow intensity and velocity was also well correlated with the growth rate as reported by single patients. In elder patients a slow rate of growth even in tumors of larger size was associated with a significantly increased flow in comparison with the normal breast tissue but this increase was not particularly large when compared with fast growing nodules in younger subjects. In conclusion the evaluation of flow characteristics (mainly velocity, frequency analysis and intensity) may be a useful index of the growth rate of nodular tumors of the breast and these data may be useful to evaluate and monitor the evolution and pathophysiology of these nodules.

Adenofibroma↗