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Biomedical subjects

G Larsen

Publications and source records attributed to G Larsen.

13 recordsLinked to original sources
PubMed1991

Partial hydatidiform mole with subsequent trophoblastic tumor; a case report.

A case of partial hydatidiform mole revealed by genetic marker analysis one maternal and two paternal chromosome complements. Levels of serum human chorionic gonadotropin were persistently elevated during follow-up. Avillous curettage specimens prior to chemotherapy were morphologically suspicious for gestational choriocarcinoma. It is still uncertain whether the risk for gestational choriocarcinoma preceded by partial mole exceeds the risk related to non-molar abortions. Careful follow-up with serial serum human chorionic gonadotropin levels is required to detect persistent disease.

Adult↗
PubMed1991

Incidence of molds and mycotoxins in commercial animal feed mills in seven midwestern states, 1988-1989.

A total of 82 feed manufacturers located within seven midwestern states (Iowa, Nebraska, Minnesota, Illinois, Indiana, Ohio, Michigan) participated in a survey of mold and mycotoxin contamination of corn. Samples were submitted from a composite of the grading samples taken from each incoming load of corn. The survey was initiated in July 1988. During the 12-mo period, moisture content of the corn samples upon receipt at the laboratory ranged from 10.5 to 13.3%. The greatest variation occurred in the springtime. Iowa's corn samples were driest (11.2%), and samples submitted from Ohio were wettest (12.8%). Mold counts averaged 2.63 x 10(4) per gram during the year. The predominant mold found was Fusarium sp. Samples were checked by black light and averaged 25.4% positive during the period. When assayed for mycotoxins, 19.5% of the samples were positive for at least one of the following: aflatoxin, zearalenone, T2 toxin and deoxynivalenol (vomitoxin). Aflatoxin and T2 toxin made up the majority of these samples containing toxin. The highest incidence of mycotoxin-contaminated corn (48%) occurred in samples submitted in July of 1988. Over the 12-mo period, the highest mycotoxin contamination occurred in Iowa, Illinois and Michigan. When samples were subjected to 90% relative humidity and 32 degrees C, an average of 3.9 d was required for mold growth to appear. After incubation, 24.7% of the samples contained one of the four toxins. The data indicate that mold and mycotoxin contamination of mixed samples of corn is widespread, even in the midwestern corn belt of the U.S.

Aflatoxins↗
PubMed1991

Hydatidiform mole and fetus with normal karyotype: support of a separate entity.

Repetitive hydatidiform mole was observed in four pregnancies. The pregnancies presented with heavy bleeding and vomiting, but the post-evacuation courses were uncomplicated, with rapid regression of serum hCG levels. Cytogenetic investigations, analyses of restriction fragment length polymorphisms, and flow cytometry in three pregnancies were consistent with diploid, biparental conception as the origin of fetal tissue and molar and nonmolar villi. In one pregnancy, the analyses of cytogenetic markers suggested the coexistence of two different cell lines of dizygotic, biparental origin, whereas DNA analysis was consistent with a single conception. With incomplete genetic information, a hydatidiform mole with coexistent normal fetus is generally considered to result from dizygous twinning comprising an androgenetic complete mole and a normal conception. In the present gestations, the results based on several techniques applied on numerous samples from different tissues render this possibility unlikely. Some of the contradictions between histologic and cytogenetic classifications of hydatidiform mole may be explained by diploid, biparental partial mole, which seems to constitute a separate subgroup within hydatidiform mole. Following chorionic villus sampling or amniocentesis, continued pregnancy may be considered, depending on prenatal diagnosis including genetic marker analysis.

Adult↗
PubMed1990

Lymphocyte subpopulations in patients with cervical intraepithelial neoplasia.

Quantitation of T-lymphocyte subsets and natural killer cells in peripheral blood of 16 patients with cervical intraepithelial neoplasia and 15 controls with normal cervical cytology was performed using specific monoclonal antibodies and flow cytometry. No differences were observed in T-helper lymphocytes, T-suppressor/cytotoxic lymphocytes, Th/Ts cell ratios, or natural killer cells. The results indicate that disturbances of the cell-mediated immune response, observed in patients with invasive cancer of the cervix, are secondary to the disease and of no significance in the initiation of cervical cancer.

Female↗
PubMed1990

Laser conization: follow-up in patients with cervical intraepithelial neoplasia in the cone margin.

Combination laser conization was performed in 469 patients for the treatment of cervical intraepithelial neoplasia (CIN). In 58 cases (12.4%), CIN was located in the margins of the cone. Fifty-one patients with involvement of the margins were evaluated by cytologic examination, using the Ayre spatula and the Cytobrush, and by cervical biopsy and endocervical curettage (ECC). In six cases, the histologic evaluation was positive, and in three of these cases, the cytology was positive too. Hysterectomy was performed in five cases, but in only one case was a significant lesion demonstrated in the uterus. These results justify expectant, conservative management of patients treated with combination laser conization. Follow-up based on colposcopy and cytology seems sufficient.

Aged↗
PubMed1989

Experimental data on in vitro fibre solubility.

Different types of natural and synthetic fibres have been subjected to systematic solubility tests in vitro in a physiological solution at 37 degrees C. Both closed-system and open-system experiments were carried out. Atomic absorption spectrometry of the filtered fluids showed characteristic differences of solubility. Plastic fibres are practically insoluble. In contrast to glass fibres, the solubility of asbestos fibres is low. Sepiolite and wollastonite are of moderate solubility. The results were confirmed by scanning electron microscopy. Kinetic studies and extensive solubility tests led to a new exponential expression which describes the dissolution process in a closed system better than the square-root time laws often used. Moreover, this exponential model provides a new method of distinguishing between different materials by means of their initial rates of dissolution.

Asbestos↗
PubMed1975

Structural X-chromosome abnormality in a female with gonadal dysgenesis.

A patient with gonadal dysgenesis and 46 chromosomes is described. In the inactive X chromosome there seems to be a deletion of the short arms and an insertion of heterochromatin in the long arms. The most probable mechanism to explain this structurally abnormal X is a pericentric inversion, with breakage and union having occurred in the centromeric heterochromatin of the short arm and in band q23 of the long arm. An amplification of the centromeric heterochromatin left in the short arm is also supposed.

Adult↗