Search PubMedSearch

Biomedical subjects

G Lapointe

Publications and source records attributed to G Lapointe.

At least 19 recordsLinked to original sources

Toxicological index and the presence in the workplace of chemical hazards for workers who breast-feed infants.

The increasing number of women in the workplace has made it more important than ever to ensure a safe work environment, particularly with respect to mothers who choose to breast-feed their babies. The Quebec Commission de la santé et de la sécurité du travail (CSST) Toxicological Index is fully involved in the provincial program for the protective reassignment of workers who breast-feed infants. The Infotox database provides peer-reviewed information concerning chemicals identified in the workplace that may appear in the mother's milk, possibly to be ingested by the breast-fed infant. Data extracted from the CSST computer system that holds information on 5,500 substances are presented. A total of 153 chemicals (2.7%) are recognized as being involved in some milk transfer. The strength of evidence is assessed with reference to strong or weak association (excretion or detection) in humans or in animals. Such an effect provides a useful basis for administrative decision involving protective reassignment as well as evaluation of work environment. Database users must be well informed about the identification of chemicals in breast milk because this is an essential step for the evaluation of the hazards of transferring chemicals encountered in the workplace from mother to baby. Actually, the main problem is that there are very few data in the scientific literature concerning milk transfer.

Breast Feeding

Computerized product information system: The Toxicological Index.

The Toxicological Index, a division of the Commission de la Santé et de la Sécurité du Travail, was established in 1980 by the Quebec Government. Its main objective, as a database producer, is to provide health and safety related toxicological information to anyone who is involved in risk management in the workplace. In order to meet this requirement, a fully computerized information system was created. It has allowed us to process, over the past 5 years, 250,000 information inquiries, to register 100,000 contaminants, to exchange information with 3,300 product manufacturers and to provide our users with 6,500 fully reviewed toxicological information profiles. The procedure used to assess the information as well as the choices made to achieve our objective in terms of quantity and quality of the information provided are described.

Chemical Phenomena

A rat model of neurobehavioral development.

The neurobehavioral evolution of the normally growing rat has been investigated by means of a series of reflex, motor and sensory tests from birth up to weaning. A sequential development of behavioral responses has been assessed over this 21-days period, and 2nd week following birth representing an important step in the neurobehavioral maturation of the rat. This rat model may be considered as an useful reference to evaluate changes that may be induced by pharmacological and toxicological agents in the developing exposed rat.

Animals

Saccharin- or quinine-induced changes in the rat pups following prolonged ingestion by the dam.

Effects presumably induced by a chronic free ingestion of saccharin (0.40 mg/ml) or of quinine (0.25 mg/ml) by female rats during the pregestative, gestative and lactating periods were investigated in the ensuing progeny. Preweaned pups were studied from birth up to weaning (21 days of age) by means of selected gross behavioral tests. The saccharin litters were mainly characterized by a slowering in the body growth evolution. The quinine pups demonstrate several physical anomalies: (1) congenital malformations in 5% of the animals; (2) a significantly reduced birth weight followed by a persistent growth retardation, and (3) a significant delay in the teeth eruption (1.6 and 2.6 days) and in the eye openings (1.6 days). In comparison to the untreated offspring, the saccharin pups showed minor effects whereas quinine-exposed rats were clearly impaired in several features of the postnatal physical development. Therefore, the addition of the sweetener to morphine solution may be convenient for the voluntary oral consumption of the narcotic. Conversely, quinine, used to habituate animals to drinking bitter solutions, has to be rejected in this narcotization procedure as being a harmful agent to the growing rat.

Abnormalities, Drug-Induced

[Neo and postnatal development of the cerebral cortex in mice. Ultrastructural study].

Maturation in the Purkinje cell (Pk) of the cerebellar cortex of developing mice (from birth up to weaning) was investigated by structural and especially ultrastructural studies. In comparison to the adult neuron, four developmental stages were identified by studying selective morphological features (shape and size of the Pk, neuronal environment) as well as specific characteristics of neuronal constituants, particularly the "nucleus-ribosome system". The stages are: early, intermediate and late neuroblasts and young neuron. The neuronogenesis of the Purkinje cell can be summarized as follows: (a) the nuclear maturation occurs early in the development and markedly preceeds that of several organelles in the perikaryon; (b) the cytoplasmic maturation extends gradually until the young neuron state was reached. Some structures such as the granular mass and the "spotted body" in the nucleus, the nuclear envelop including its two membranes, and the ribosomal components either free or attached to the Endoplasmic Reticulum seem to exert an important role during neuronal development. Maturation processes in the Purkinje cell are generally similar in both mouse and rat and, except for some morphological and/or chronological variables, comparable in others developing nerve cells. This model of neuronal maturation is used alone or in comparison to another model of neuro-behavioral evolution which was established concommitantly. Both of these models reveal to be very useful for the evaluation of the effects induced in the developing animal following the administration of neuropsychotropic drugs such as Hallucinogens and Narcotics.

Animals

[Primary health care].

Explore the source record for details and available documents.

Education, Nursing, Graduate