By a structural combination of phosphonate and bisphosphonate moieties with the vitamin D skeleton a series of new vitamin D analogs was synthesized. Derivatives with 24beta-hydroxy- or 24-keto groups exerted considerable vitamin D activities in vitro while the hypercalcemic potentials were significantly reduced as compared to 1alpha,25-dihydroxyvitamin D(3) (calcitriol). Whereas the 24-hydroxy analogs did not influence bone formation in vivo in dosages below the hypercalcemic threshold, the 24-ketones were found to induce synthesis of new bone matrix in non-hypercalcemic doses. Vitamin D bisphosphonate hybrids, on the other hand, which did not elicit substantial vitamin D activities in vitro and tend to decrease serum calcium levels in vivo clearly induced osteoid formation in rats, indicating a mechanism of action different to calcitriol.

Animals↗

PubMedDate not supplied

Artificial insemination. A study of 156 successful cases.

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Adult↗

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Haloperidol and droperidol treatment in schizophrenics. Clinical application of the "prolactin-model".

Longitudinal studies are presented in four schizophrenic patients to investigate further the relationship between neuroleptic treatment (haloperidol or droperidol), plasma prolactin response, suppression of neuroleptic-induced prolactin elevation by dopamine infusion, and psychopathological change. Several unexpected findings related to neuroleptic-induced prolactin response and its suppression by dopamine infusion have been observed. Data appear to open up new vistas for the validity of the 'prolactin model' in studying the pharmacodynamics of neuroleptic drugs.

Adult↗