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Biomedical subjects

G Lang

Publications and source records attributed to G Lang.

At least 217 records · Page 12Linked to original sources
PubMed1972

A new subtype of type A influenzavirus isolated from turkeys.

A new subtype of avian influenzavirus A was isolated in January 1967 from an epizootic in a turkey hatchery in Ontario, Canada. The disease was fatal in 65 of 2 500 hens involved. Virus was isolated from lung and trachea tissue of three dead turkeys. Sera from convalescent birds contained antibody against the viruses isolated from the outbreak but not against other known type A avian influenzaviruses, Newcastle disease virus, Myxovirus Yucaipa, or Mycoplasma gallisepticum.The strain designated A/turkey/Ontario/6118/67 contained the influenza A type ribonucleoprotein. Haemagglutinin and neuraminidase antigens of the strain differed antigenically from the envelope antigens of other avian influenzaviruses isolated from birds, horses, pigs, or man. The designation of turkey/Ontario/6118/67 as containing haemagglutinin of avian subtype 8 (Hav 8) and neuraminidase of avian subtype 4 (Nav 4) is proposed.

Animals↗
PubMed1971

A new influenza A virus infection in turkeys. VII. Comparative immunology.

Four influenza A strains isolated from turkeys in Ontario as well as strain Chicken/Scotland/59 were found to immunize turkeys against the lethal disease caused by virus Turkey/Ontario 7732/66 (V7732). These viruses form the avian influenza A serotype 5 (AA5). Immunoprotection against V7732 was not obtained with influenza viruses of other serotypes. Immunoprotective relationships among AA5 viruses were not always demonstrable in hemagglutination-inhibition (HI) and serum-neutralization (SN) tests, especially with turkey and mammalian antisera; better correlation between immunoprotection and these in vitro tests was seen with chicken antisera. The implications of these findings relative to virus classification, serodiagnosis and vaccination are discussed.

Animals↗
PubMed1970

A new influenza A virus infection in turkeys. VI. Artificial immunization against the malignant virus strain turkey-Ontario 7732-66.

The immune reaction of turkeys and chickens to inactivated preparations of a virulent strain of avian influenza A virus has been examined. In both species any level of antibody detectable by the hemagglutination inhibition or serum neutralization tests was protective against the challenge exposure. However, some vaccinated birds were protected in the absence of detectable antibody. Chickens responded with higher and longer lasting antibody titers than turkeys to identical antigen preparations. Whereas the vaccine induced protection in chickens for at least 84 days, the immune protection in turkeys barely lasted 42 days. Immune birds responded to the live virus challenge with a marked rise in serologic titers which suggest that they were still susceptible to subclinical infection. These findings are discussed in their relationship to available data on classical fowl plague and influenza in mammals.

Animals↗