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Biomedical subjects

G Landbeck

Publications and source records attributed to G Landbeck.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Cytological classification and nomenclature of leukaemias in childhood. Present situation of the cytomorphological and cytochemical differentiation (author's transl)].

The classification and nomenclature of leukaemias in childhood under cytomorphological and cytochemical criteria is presented base on our own longstanding studies as well as on literature. Particular consideration is given to clinically relevant subtypes of acute lymphoblastic leukaemias (ALL), acute myeloid leukaemias (AML) and chronic myeloid leukaemias (CML). The more subtle differentiation leads to a more reliable diagnosis, a better estimation of the individual prognosis and is of immediate importance for the therapeutical decisions. We show the necessity of diagnosis centralisation in cooperative prospective therapy studies and in a risk dependant therapeutical approach.

Acute Disease↗
PubMed1977

[Clinical significance of cytochemical findings of childhood acute lymphoblastic leukaemia (author's transl)].

The initial bone marrow smeasrs of 821 children with ALL have been cytochemically analysed. (PAS-, acid phosphatase-(SPH), peroxydase-(POX), alpha-N-esterase-(EST)reaction) with regard to presenting clinical data and course of disease. Granular reactions of PAS and SPH were not meaningful in this respect. The paranuclear SPH-reaction was associated with high incidence of mediastinal mass, high peripheral blas count and male preponderance. All 5 patients with histories of more than 12 weeks duration belongs to the PAS-type of ALL (cloddy reaction). The PAS-type showed a higher incidence of CNS-leukaemia and generally a less favorable prognosis as compared to the UND-type. Thereby a high proportion of PAS positive cells, independently of other risk factors, indicates a better prognosis. The highterto neglected weak EST-reaction (Grad I and II according to Löffler) seems to signalise a clincally distinct subtype of ALL with a younger age distribution maximum as compared to the UND-type, low incidence of risk factors, high rate of remissions lasting more than 2 years but unfavorable endprognosis.

Acid Phosphatase↗
PubMed1977

[Acute lymphoblastic leukemia and lymphoblastic lymphoma. Two names for one disease (author's transl)].

Of 14 non-T-cell malignant non-Hodgkin lymphomas (mNHL) 5/14 presented with leukemic transformation of the bone marrow; in three more cases bone marrow involvement developed during an observation period of 60--200weeks. In 2/14 cases mNHL terminated the first continuous and complete remission of acute lymphoblastic leukemia (ALL). CNS involvement has been observed without preceding bone marrow involvement. Only 4/14 mNHL remained local diseases. These clinical courses as well as hematological findings and further clinical observations suggests a very close relationship between mNHL and ALL if not basic identity. With the same systemic treatment additional to local treatment, prognosis of mNHL is by no means worse but rather better than the prognosis of ALL.

Bone Marrow Cells↗
PubMed1977

[Malignant mediastinal lymphoblastic lymphoma with t-cell ALL (author's transl)].

29 cases of T-cell derived lymphoblastic lymphoma and T-ALL have been analyzed. There is a striking prevalence of the male sex. In the peripheral blood we often find initially an excessive number of white blood cells combined with normal values for the other constituents in about half of the patients; This may be an expression for the rapid occurrence of leukaemia in T-cell lymphosarcoma. In addition to systemic ALL-therapy we performed X-ray irradiation of the mediastinum in 8 of our patients. This yielded to significantly longer first complete remissions. All patients with T-cell LSA/ALL with or without mediastinal mass should be treated in this manner. Cytochemically a strong focal acid phosphatase reaction was found to be acharacteristic of these cells. It has proved to be a screening method for this disease. The cells are T-cell derived and their pattern of surface markers is similar to that found in fetal thymocytes.

Acid Phosphatase↗
PubMed1976

Lymphoblastic lymphoma of convoluted or acid phosphatase type-a tumor of T precursor cells.

Five lymphatic neoplasms with strong focal acid phosphatase reactivity were selected from a group of acute lymphocytic leukemias and lymphoblastic lymphomas. All five cases showed an anterior mediastinal mass and exhibited identical morphology. This type of lymphoma has been described by Lukes under the term "malignant lymphoma of convoluted lymphocytes". Analysis of surface membrane receptors revealed that the tumor cells lacked surface immunoglobulin and receptors for Fc-fragment, but possessed receptors for complement (C3), untreated SRBC (ES) and SRBC treated with neuraminidase (ESN). By applying a mixed rosette assay using nucleated chicken erythrocytes coated with antibodies and C3, and denucleated ESN, it was found that a considerable number of tumor cells in all five cases formed mixed rosettes, i.e. that they bore the C3 receptor characteristic of B cells and simultaneously the E receptor characteristic of T cells. Thus the tumor cells resembled immature thymocytes of 10-15 weeks' gestation, which also show focal acid phosphatase reactivity and simultaneous expression of C3 and E receptors.

Acid Phosphatase↗
PubMed1975

[Immunological cell markers on lymphoblasts of patients with acid phosphatase positive acute leukemia (author's transl)].

Blast cells of 4 patients with acid phosphatase positive acute leukemia were investigated for T and B lymphocyte markers. Nearly all blast cells showed a typical T cell marker, namely spontaneous rosette formation with sheep red blood cells. No surface immunoglobulin was demonstrable on these cells. 3 of these 4 patients showed an enlargement of the upper mediastinum most probably due to the thymus. The conclusion is drawn that the acid phosphatase positive acute leukemia is a T cell leukemia. Some clinical data about these 4 patients are given.

Acid Phosphatase↗
PubMed1975

[Bleeding disorders and childhood ENT diseases (author's transl)].

The diagnosis and management of ENT patients with coincidental bleeding dyscrasias presents special difficulties, which include diagnosis of the disorder, arrest of the bleeding when unexpected, and the conservative and surgical care of affected children with ENT diseases. The dyscrasias most often found in childhood are haemophilia, von Willibrand's disease and ideopathic thrombocytopenic purpura. The clinical presentation and course of these disorders are described. Present day treatment is effective in arrest of the haemorrhage such that a fatality can almost always be avoided. The close cooperation between specialist paediatricians and haematology departments in the handling of these patients is stressed.

Hemophilia A↗