Biomedical subjects
G Lamb
Publications and source records attributed to G Lamb.
Hepatic artery ligation and embolization for the carcinoid syndrome--report of intra-operative liver blood flow studies in a case with high substance P concentration in liver metastases.
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The librarian in clinical care.
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Bridging the information gap.
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A study of astronauts' extravehicular work capabilities in weightless conditions. NASA CR-1334.
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Interventional MR-guided excisional biopsy of breast lesions.
Interventional MR (IMR) machines have produced unique opportunities for image-guided surgery. The open configuration design and fast pulse sequences allow intraoperative scanning to monitor procedures. This study was undertaken to assess the potential use of IMR for image-guided surgery. Benign breast lesion excision was chosen as an uncomplicated surgical model. Ten female patients with known benign tumors underwent excision biopsy under general anesthesia in a Signa SP10 .5-T IMR machine (General Electric Medical Systems, Milwaukee, WI). Lesions were localized with precontrast and postcontrast (intravenous gadolinium-diethylenetriamine pentaacetic acid, .2 mmol/kg) fast multiplanar spoiled gradient-recalled acquisition in the steady state (GRASS) sequences. Preoperative "real-time" fast gradient-recalled sequences were also obtained using the Flashpoint (General Electric Medical Systems, Milwaukee, WI) tracker device. The maximum dimensions of each lesion were measured from the resulting images. Excision was performed using titanium instruments and an ultrasonically activated scalpel. Intraoperative real-time scanning demonstrated the resection margin and confirmed complete excision. The maximum dimensions of the macroscopic specimens were compared with those from the MR images. All tumors were visualized with the Signa scanner and real-time imaging and the images were enhanced after intravenous contrast. Maximum dimensions on histologic examination were not significantly different from those measured from Signa (P > .17) or real-time images (P > .4). There was no significant difference between lesion size from Signa and real-time images (P > .25). All postprocedure scans demonstrated complete excision. There were six fibroadenomas, two foci of sclerosing adenosis, one area of fibrocystic disease, and one schwannoma. Intraoperative MR scanning reliably identifies palpable breast tumors and can accurately guide surgical excision. Further work using MR guidance can now be performed in other general surgical areas.
Central compartment pressure monitoring following clubfoot release.
Thirty-nine clubfeet undergoing primary soft tissue release for idiopathic clubfoot deformity had intrinsic compartment pressure monitoring for 36 h after surgery. This was done to determine whether pressures might be elevated to levels, and for durations, such that an intrinsic compartment syndrome might develop. Two groups were identified: in group 1 (23 feet) pressures were never elevated to > 20 mm Hg; in group 2 (16 feet) pressures > 30 mm Hg for a duration of at least 12 h were found. In a subgroup of group 2 (4 of 16 feet), pressures were > 50 mm Hg for at least 12 h. There was no statistical correlation between pressure recordings and surgeon, tourniquet time, severity of deformity, extent of release, and type of cast used. Thus 40% of feet are at risk of developing pressures that could cause an intrinsic compartment syndrome.
The impact of the cancer experience on long-term survivors.
Little is known about the impact of the cancer experience on long-term survivors of adult cancers. This exploratory study describes survivors' needs and identifies emic (in the subject's own words) categories and patterns among physiological, psychological, and socioeconomic changes, problems/concerns, and needs. A purposive sample of 17 adults more than two years post-cancer therapy was interviewed using the semi-structured Cancer Survivor Questionnaire (CSQ). Deductive content analysis was used to identify specific changes, problems/concerns, or needs associated with physiological, psychological, and socioeconomic categories. Inductive content analysis identified major emic themes and patterns. Findings indicate that the cancer experience permanently changes life patterns and suggest guidelines for nurses to use in helping the cancer survivor better adapt holistically to long-term survival.