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Biomedical subjects

G Laino

Publications and source records attributed to G Laino.

At least 19 recordsLinked to original sources
PubMed1993

Gastric bicarbonate secretion in high-relapsing, smoking duodenal ulcer patients.

Gastric bicarbonate secretion has been evaluated by Feldman's method in 48 duodenal-ulcer patients. The relationship between smoking, clinical ulcer outcome (healing and recurrence) and bicarbonate secretion has been analysed. Heavy smokers secreted higher bicarbonate ions than did non-smokers. High-relapsing patients produced lower bicarbonate output. These preliminary data suggest that an impaired gastric bicarbonate secretion is associated with smoking, a well-known ulcer-associated factor; further-more, it may single out high-relapsing duodenal ulcer patients.

Adult↗
PubMed1993

[Alcohol-dependent mast cell activation in ulcer].

Numerous studies have shown that alcohol causes both acute and chronic damage to gastroduodenal mucosa. The methods of damage differ however, and experimental studies in animals have shown that the degranulation of mast cells in gastric mucosa causes acute hemorrhagic lesions after the consumption of alcohol. It is not known whether this mechanism also operates in man. The aim of the present study was therefore to evaluate whether there is a correlation between mast-cell activation, determined by assaying tryptase levels in gastric mucosa, and the consumption of alcohol in patients with ulcerative diseases. Thirty-one patients with cicatrized ulcerative lesions (13 gastric ulcers, 18 duodenal ulcers) were included in the study. Biopsies at the level of the gastric fundus and antrum and the duodenal bulb were performed in all patients to determine tryptase levels. Biopsy material was frozen and subsequently homogenized; the enzyme was assayed in the supernatant using a radioimmunometric method. The mean daily alcohol consumption was calculated in clinical terms for each patient over the past 5 years and patients were subdivided into non-drinkers and moderate (< 60 g alcohol/day) and excessive (> 60 g alcohol/day) drinkers. It was found that tryptase concentrations were higher in the fundus compared to the gastric antrum and duodenal bulb, irrespective of alcohol consumption both in patients with gastric ulcer and duodenal ulcer. The importance of mast cells in provoking alcohol-dependent damage was studied at a gastric level. Alcohol leads to their degranulation and therefore contributes to the formation of gastric lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

Esaprazole effect on acid, peptic and alkaline secretion in duodenal ulcer patients.

To study the effect of Esaprazole, a new antiulcer drug, on acid, peptic and alkaline secretion a modified gastric acid test was performed in 18 duodenal ulcer patients. Pentagastrin was administered as bolus 30' and 75' after the beginning of the test, followed by Esaprazole 300 mg i.v. at 90'. Gastric juice was collected every 15' for determination of: total volume, volume of non parietal secretion, acid, bicarbonate and pepsin output. Serum pepsinogen group I was determined by radioimmunoassay. Esaprazole had a significant inhibitory effect on the total volume of gastric secretion and on volume of non parietal secretion. Pepsin output and serum pepsinogen group I were not affected by Esaprazole, while bicarbonate secretion was reduced. Antiulcer activity of Esaprazole seems to be due to the reduction of total volume of gastric secretion.

Adult↗
PubMed1988

[Cementoma of the jaw. Clinical case].

The A.A. describe a case of cementoma come to their observation, reporting considerations resulting from an attentive analysis of the literature on the subject.

Adult↗
PubMed1988

[Anatomophysiological aspects of osteoclasts].

The AA. examine the current understanding of various aspects of the theories about cell origin, ultrastructural features and mechanism (one-cell or two-cell) of bone degradation of the osteoclasts.

Bone Resorption↗
PubMed1988

[Oral frenula].

Explore the source record for details and available documents.

Diastema↗
PubMed1988

[Histocompatibility antigens expressed in the epithelium of the oral mucosa during various diseases].

The AA. report the expression of the Class I and II major histocompatibility antigens on oral mucosa Class I and II antigen expression varied between various disease states exhibiting proliferative or destructive tissue responses, and this expression is consistent with major histocompatibility complex (M.H.C.)-restricted cellular interactions. Oral mucosa doesn't express HLA-DQ antigens.

Histocompatibility Antigens Class I↗
PubMed1988

[Chondroma].

Chondroma: the A.A. describe the characteristics of etiopathogenetic, anatomy-pathological, clinical, diagnostic and therapeutical order of this uncommon pathology.

Chondroma↗
PubMed1988

[Keratoacanthoma].

The A.A. describe the characteristics of etiopathogenetic, anatomy-pathological, clinical, diagnostic and therapeutical order of keratoacanthoma.

Humans↗