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Biomedical subjects

G Lagrue

Publications and source records attributed to G Lagrue.

At least 199 records · Page 11Linked to original sources
PubMed1983

[Hyperimmunoglobulinemia E syndrome with recurrent infections (Buckley's syndrome) associated with membranoproliferative glomerulonephritis. A case in an adult].

A 35-year old male patient who, since the age of 17, had membranoproliferative glomerulonephritis presented with recurrent atopic eczema and sinusitis. Outbursts of eczema, sinusitis and proteinuria occurred simultaneously. Signs of immune deficiency, with permanently extreme IgE levels (greater then 10.000 I.U/ml), defective neutrophil chemotaxis and monocyte phagocytotic function (Buckley's syndrome) were present. The role of these abnormalities in the pathogenesis of glomerulonephritis (chronic antigen production associated with focal infection and resulting in the formation of immune complexes, defective elimination of these circulating immune complexes) is discussed.

Adolescent↗
PubMed1983

The effects of chronic renal insufficiency on the pharmacokinetics of doxycycline in man.

The pharmacokinetics as well as erythrocyte and plasma protein binding of doxycycline were studied in fifteen patients with various renal function impairments after oral doxycycline polyphosphate single administration. Plasma half-life (t 1/2), area under the plasma concentration-time curve (AUC), urinary excretion, renal clearance, erythrocyte and plasma protein binding (%) were regressed vs creatinine clearance. No significant correlations were observed between t 1/2 or AUC and renal function nor plasma protein binding and plasma albumin concentrations. Significant correlations were obtained between urinary excretion, renal clearance, erythrocyte binding, plasma protein binding and creatinine clearance. Significant correlation was obtained between haematocrit and erythrocyte binding. Constancy of overall elimination parameters in renal failure is due to parallel increase in plasma free fraction of doxycycline.

Adult↗
PubMed1983

[Plasma and urinary antithrombin III in the nephrotic syndrome in adults].

The occurrence of thromboembolism in nephrotic syndrome has been recently correlated with acquired antithrombin III (AT III) deficiency (and this raised the question of the prevention and treatment of thromboembolism with heparin). We studied AT III levels in plasma and urine in 39 adults with nephrotic syndrome. Three patients have had thromboembolic manifestations (before treatment with heparin). Their albuminemia was less than 18 g/l, their plasmatic AT III levels were normal and one had an elevated urine AT III level. Plasmatic AT III levels and albuminemia were positively correlated (r = 0.34; p less than 0.05) but AT III levels remained in the normal range being moderately diminished in only 3 patients never less than 70 p. 100. There was no correlation between plasmatic AT III level and proteinuria or urinary AT III levels. We conclude that the risk of thromboembolism in adults with nephrotic syndrome is not correlated with plasmatic AT III levels. This suggests that heparin therapy would be effective in preventing thromboembolism in this disorder. Indeed, no such episodes were seen in our patients under heparin.

Adolescent↗
PubMed1983

[Phagocytic activity of monocytes tin glomerulonephritis in complete remission].

Circulating immune complexes (CIC) account for a majority of GN. Their pathogenicity depends on size, molecular composition, glomerular hemodynamics and activity of phagocytes. The phagocytic function of peripheral monocytes was studied in 23 patients with non-systemic active GN and in 16 GN in complete remission. Phagocytic activity of peripheral blood monocytes was assessed in vitro, by calculating phagocytic index (IP: number of zymozan particles in each monocyte) and phagocytosis percentage (PP: number of phagocyting monocytes); the tests were carried out on autologous and heterologous serum samples. In 13 controls, PP was 79 +/- 5.8%. In 7 membranous GN, 6 membranoproliferative GN and 10 lipoid nephrosis, PP was severely decreased, 63.4 +/- 9.6%, 52.1 +/- 19% and 52.2 +/- 14%. In each group of GN, these results were significantly different from controls (p less than 0.01). In all groups these results were similar in autologous and heterologous serum samples (55 +/- 13% and 57.5 +/- 16%; NS). This perturbation was not observed in GN in complete remission. Therefore, this defect was not linked to the presence of serum inhibitors. In conclusion, alterations of phagocytic activity is present in some primary active GN and may explain an insufficient rate of CIC removal.

Antigen-Antibody Complex↗
PubMed1983

[Experimental prevention of a hemolytic disease of the fetus with F (ab)'2 immunoglobulin fragments].

An experimental study was designed to tentatively protect fetal red blood cells (RBC) against hemolysis by covering fetal RBC antigenic sites with F (ab)'2 fragments of hemolysing antibodies. Sheep antibodies were raised against rabbit RBC. IgG were separated and part of the IgG pool subjected to pepsin digestion, in order to isolate F (ab)'2 fragments. Near term rabbit fetuses were injected through the uterine wall with either IgG, F (ab)'2 or successively F (ab)'2 then IgG. Fetuses were extracted by hysterotomy, one hour after the last injection. Neonatal blood was collected by cardiac puncture for hematocrit determination and detection of hemolysis. Among fetuses injected with IgG alone, nine were deal at hysterotomy and evidenced diffuse hemorrhagic syndrome. Six were born alive with hemolysis, including three with severe anemia. (Ht = 26%). Nine fetuses successively injected with F (ab)'2 and then IgG, were all born alive with normal hematocrits (Ht = 43%). The protective role of F (ab)'2 fragments and their potential therapeutic use are discussed.

Animals↗