Biomedical subjects

G L Trick

Publications and source records attributed to G L Trick.

At least 37 records · Page 2Linked to original sources

PubMed1990

Motion perception is abnormal in primary open-angle glaucoma and ocular hypertension.

Several lines of evidence suggest that the large optic nerve fibers, which form the magnocellular retinocortical pathway, are preferentially susceptible to early glaucomatous damage. It is evident from studies of the functional architecture of the visual system that the magnocellular pathway underlies the global perception of motion. Therefore, we have developed a psychophysical technique for assessing motion detection thresholds in patients with ocular hypertension (OHT) and primary open-angle glaucoma (POAG). For this purpose we employed a dynamic random dot display that contained varying degrees of a coherent motion signal embedded within a background of random motion noise. We used this technique to measure motion thresholds in POAG patients (n = 37), OHT patients (n = 14), and age-matched controls (n = 39). Motion thresholds were elevated by 70% for the POAG group and 44% for the OHT group relative to controls. In the same patients, no significant deficit in form discrimination was found as measured by Pelli-Robson charts. Our results demonstrate that significant motion perception deficits are evident in POAG and OHT. These findings support the suggestion that significant and selective damage to the magnocellular pathway occurs in OHT and POAG and indicate that motion threshold testing may reveal preclinical optic nerve disease in early POAG.

Contrast Sensitivity↗

PubMed1989

Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer type.

Patients with senile dementia of the Alzheimer type frequently have difficulty performing visual tasks. These difficulties may be due, at least partially, to degenerative changes in both the primary visual pathway and the visual association areas. To determine whether retinal ganglion cell dysfunction contributes to visual loss in senile dementia of the Alzheimer type, we tested a group of patients with this disease (n = 13) using the pattern-reversal electroretinogram to both low (4.0 reversals per second) and high (16.0 reversals per second) temporal frequency checkerboard patterns (1.0 degree checks). Significant amplitude reductions were noted for the patients relative to age-matched control subjects (n = 30). In addition, the observed amplitude reductions were most pronounced for the high temporal frequency condition. Therefore, the results are consistent with retinal ganglion cell dysfunction and support the notion that optic nerve damage induced by senile dementia of the Alzheimer type preferentially affects the larger, faster-conducting retinal ganglion cells along with their retinocortical projections.

Aged↗

PubMed1989

Assessing the utility of reliability indices for automated visual fields. Testing ocular hypertensives.

Monocular (right eye) visual fields were recorded with the Humphrey Visual Field Analyzer (30-2 Program) at baseline as well as 6 and 12 months later in 120 patients with established ocular hypertension. Indices of field reliability (fixation loss, less than 20%; false-positives and false-negatives, less than 33%) and field sensitivity (mean deviation [MD] and pattern standard deviation [PSD]) were examined. At baseline, 35% of patients exhibited low reliability (LR) fields, a figure which decreased to approximately 25% at 6 and 12 months, respectively. During this period, over 50% of patients produced at least one LR field, whereas 8.3% were unable to produce even one reliable field. Exhibition of a LR field appeared to be independent of patient age. Fixation errors, the major cause of LR fields, decreased by approximately 10% over the 12-month period; most patients had between 20 and 32% fixation errors. The incidence of significant defects identified by PSD was greater than that for MD; this was true for both reliable and LR fields. It is suggested that increasing the fixation loss criteria for assessing patient reliability to a 33% cutoff might substantially increase the percentage of fields graded reliable with minimal effect on the sensitivity or specificity of the test.

Adult↗

PubMed1988

Retinocortical conduction time in diabetics with abnormal pattern reversal electroretinograms and visual evoked potentials.

Clinically evident retinal vascular disease in patients with diabetes mellitus may be preceded by an increase in visual evoked potential latency in electrophysiologic testing. This increase may indicate either retinal or optic nerve dysfunction. To determine the origin of the latency increase we initiated a cross-sectional study of simultaneous pattern-reversal electroretinograms and visual evoked potentials. We recorded transient (3.8 reversals/second) pattern electroretinograms and visual evoked potentials using both 15' and 60' high-contrast black-white checks. Fifty-five diabetic patients (34 with no retinopathy and 21 with background retinopathy) and 34 age-matched visual normals (controls) were tested. Group data in diabetics showed significant latency increases in both tests, but not significant differences in retinocortical conduction time were noted. These results suggest that the increases in visual evoked potential latency exhibited by diabetic patients with little or no retinopathy usually reflect altered retinal function rather than optic neuropathy. Two patients with background retinopathy exhibited retinocortical conduction times that exceeded the normal mean by more than two standard deviations, suggesting that optic neuropathy may occasionally occur in diabetic patients with background retinopathy.

Adult↗

PubMed1988

The relationship between hue discrimination and contrast sensitivity deficits in patients with diabetes mellitus.

In an attempt to elucidate more fully the pathophysiologic basis of early visual dysfunction in patients with diabetes mellitus, color vision (hue discrimination) and spatial resolution (contrast sensitivity) were tested in diabetic patients with little or no retinopathy (n = 57) and age-matched visual normals (n = 35). Some evidence of visual dysfunction was observed in 37.8% of the diabetics with no retinopathy and 60.0% of the diabetics with background retinopathy. Although significant hue discrimination and contrast sensitivity deficits were observed in both groups of diabetic patients, contrast sensitivity was abnormal more frequently than hue discrimination. However, only 5.4% of the diabetics with no retinopathy and 10.0% of the diabetics with background retinopathy exhibited both abnormal hue discrimination and abnormal contrast sensitivity. Contrary to previous reports, blue-yellow (B-Y) and red-green (R-G) hue discrimination deficits were observed with approximately equal frequency. In the diabetic group, contrast sensitivity was reduced at all spatial frequencies tested, but for individual diabetic patients, significant deficits were only evident for the mid-range spatial frequencies. Among diabetic patients, the hue discrimination deficits, but not the contrast sensitivity abnormalities, were correlated with the patients' hemoglobin A1 level. A negative correlation between contrast sensitivity at 6.0 cpd and the duration of diabetes also was observed.

Adult↗

PubMed1988

Pattern reversal electroretinogram (PRERG) abnormalities in ocular hypertension: correlation with glaucoma risk factors.

The indices employed commonly for the diagnosis of glaucoma (tonometry, ophthalmoscopy and perimetry) do not always identify which patients with ocular hypertension (OHT) will develop primary open-angle glaucoma (POAG) before irreversible visual field loss is manifest (1). The human pattern reversal electroretinogram (PRERG) is a bioelectric response reflecting neural activity of the proximal retina. PRERG amplitude reductions have been observed in POAG and other diseases affecting the optic nerve and retinal ganglion cells. This study was designed to determine whether OHT patients exhibit PRERG amplitude reductions and whether PRERG results are correlated with routinely evaluated clinical parameters. Steady-state PRERG (16 rps) were elicited by high contrast (76%), phase alternating checkerboard patterns (15-20 min checks) from one eye of 130 patients with ocular hypertension and 47 age matched visual normals (AMVNs). A significant (p less than 0.05) reduction in PRERG amplitude was noted for the OHT patients and 11.5% of those patients exhibited PRERG amplitudes more than 2.0 standard deviations below the AMVN mean. PRERG amplitude was found to be positively correlated with diastolic blood pressure (DBP) and negatively correlated with age, but no correlation between PRERG amplitude and either IOP, C/D ratio, or systolic blood pressure was evident. The lack of correlation between PRERG amplitude and the commonly used clinical indices may suggest a complementary role for this neurophysiologic test in determining which OHT patients will develop glaucoma.

Analysis of Variance↗

PubMed1988

Altering body position affects intraocular pressure and visual function.

Intraocular pressure (IOP) can be altered by changing body position. This report describes two experiments evaluating variations in IOP, as well as neural functioning of the retina and visual cortex (as measured by pattern-reversal electroretinogram and visual evoked potential), associated with whole-body, head-down tilt. The subjects, ten per experiment, were visually normal with IOP less than 19. In the first experiment, IOP elevations were induced by varying the angle of tilt in discrete steps between +90 degrees (upright) and -90 degrees (inverted). In each position IOP was measured and significant elevations (up to 3x baseline) were noted. These elevations were maintained for 1 min during which simultaneous retinal and cortical biopotentials were measured. In the second experiment, 6 degrees head-down tilt was maintained for 2 hr during which time the IOP and both biopotentials were measured repeatedly. Our findings confirm the effect of body position of IOP, while also revealing that head-down tilt produces significant reductions in neurophysiological function at both the retinal and cortical levels. The neural effect is maximized when 6 degrees head-down tilt is maintained for 20 min.

Adult↗

PubMed1988

Dissociation of visual deficits in ocular hypertension.

Both acquired color vision deficiencies and abnormal pattern electroretinograms (PERGs) are observed in patients with ocular hypertension (OHT) as well as in patients with glaucoma. In the present study we determined the prevalence of both of these functional deficits in a large group of OHT patients (N = 130). Color vision was tested with the desaturated D-15 and a color confusion score was used to quantitatively assess the magnitude of the color vision deficiency. Steady-state PERGs were evoked with rapidly alternating high contrast checkerboard patterns. Color vision deficits were detected in 23% of OHTs while 11.5% of the patients exhibited significant PERG amplitude reductions. Only 2.3% exhibited both abnormalities. The results suggest that although color vision deficiencies and PERG abnormalities are both evident in OHT, they are often dissociated findings.

Adult↗

PubMed1987

Pattern reversal retinal potentials in ocular hypertensives at high and low risk of developing glaucoma.

The human pattern-reversal retinal potential (PRRP) is a bioelectrical response which reflects neural activity generated in the proximal retina. Visual diseases which affect the retinal ganglion cells and the optic nerve often produce significant reductions in the amplitude of the PRRP. PRRP amplitude reductions are frequently observed in patients with primary open-angle glaucoma. This investigation was designed to determine whether patients with ocular hypertension who are at risk of developing glaucoma also exhibit PRRP amplitude reductions. The results indicate that PRRP amplitude reductions do occur in some ocular hypertensives, but many other ocular hypertensives do not exhibit PRRP abnormalities.

Electroretinography↗

PubMed1987

Simulation of spaceflight with whole-body head-down tilt: influence on intraocular pressure and retinocortical processing.

Cephalad fluid shifts occur in the microgravity environment of spaceflight. Whole-body head-down tilt was used to simulate the influence of these fluid shifts upon intraocular pressure (IOP) and the bioelectrical activity of neural elements in the retinocortical pathway. Noninvasive techniques were used to monitor IOP, pattern reversal electroretinograms (prERGs), and pattern reversal visual evoked cortical potentials (prVEPs) when subjects were oriented either upright or in a head-down position (6 degrees or 90 degrees). The results indicate that there is a significant elevation in IOP when an individual is oriented in a head-down position. Significant alterations of neurophysiological processing in the retinocortical pathway also occur when individuals are oriented in a head-down position.

Adult↗

PubMed1986

Altered pattern evoked retinal and cortical potentials associated with human senescence.

Physiologically healthy elderly individuals often exhibit visual deficits which result from age-related changes in both the transmission characteristics of the ocular media and the functional properties of the neural elements in the visual pathway. Many of the age-related changes in the optical quality of the ocular media have been identified, but the age-dependent variations in visual neurophysiology have not been clearly delineated. This investigation examined age-related alterations in pattern-specific biopotentials generated in the human retina and visual cortex. Counterphasing (2.0 and 7.5 rps) patterns (7.5', 15', 30' and 60' checks) were used to simultaneously monitor pattern-reversal visual evoked potentials (PRVEPs). Young visual normals (20-30 years of age) and healthy elderly observers (70-80 years of age) with visual acuity of 20/30 or better were studied. All data were corrected for the effects of senile miosis on retinal illumination. Significant variations in the waveform characteristics of both biopotentials were noted for the elderly individuals. PRRP amplitude was uniformly reduced for all stimulus conditions. PRVEP amplitude reductions were also noted but were more stimulus specific than the PRRP amplitude reductions. No significant PRVEP or PRRP latency changes were observed. These results suggest that alterations in the physiological properties of neural elements in both the retina and visual cortex are associated with normal aging.

Adult↗

PubMed1986

PRRP abnormalities in glaucoma and ocular hypertension.

The human-pattern reversal retinal potential (PRRP) is a bioelectrical response that reflects neural activity generated in the proximal retina. Visual diseases which affect the retinal ganglion cells and the optic nerve often produce significant reductions in the amplitude of the PRRP. PRRP amplitude reductions are frequently observed in patients with primary open-angle glaucoma (POAG). This investigation was designed to determine whether patients with ocular hypertension (OHT) who are at risk of developing POAG also exhibit PRRP amplitude reductions. High contrast (76%), rapidly counterphasing (16 rps), phase alternating checkerboard patterns (15-120 min checks) were used to elicit PRRPs from patients with POAG (n = 12) and OHT (n = 24), as well as age-matched visual normals (n = 11). The patients with OHT were selected to be either at high or low risk of developing POAG. The results indicate that PRRP amplitude reductions similar to those exhibited by POAG patients do occur in some OHT patients. However, many other ocular hypertensives, particularly those at low risk of developing POAG, do not exhibit PRRP abnormalities.

Analysis of Variance↗

PubMed1985

Retinal potentials in patients with primary open-angle glaucoma: physiological evidence for temporal frequency tuning deficits.

The pattern-reversal retinal potential is a bio-electrical signal which can be recorded from the cornea of the human eye when a phase-alternating (contrast-reversing) pattern is viewed. The PRRP is correlated with activity of the retinal ganglion cells and visual diseases which affect the proximal retinal layers (such as optic atrophy and optic neuritis) and cause significant alterations in the waveform of the human PRRP. This study examined the PRRP in 32 patients with primary open-angle glaucoma (POAG) and 32 age-matched visual normals (AMVNs). Counterphasing (2, 4, 8 and 16 reversals/sec) checkerboard patterns (15', 30', 60', and 120' checks) were used as visual stimuli. PRRP amplitude was significantly reduced in patients with POAG. When temporal frequency was held constant, the magnitude of the observed PRRP amplitude reductions was identical for all check sizes. However, the magnitude of the observed amplitude reductions increased as temporal frequency increased. Therefore, in patients with POAG, the shape of the PRRP spatial tuning function was normal (although uniformly reduced for all check sizes), while the temporal tuning function was attenuated for high frequencies. Statistically significant increases in PRRP latency were also observed in the POAG patients, but these increases were quite small (mean = 3.6 ms).

Aged↗

PubMed1984

Power spectral analysis of visual evoked potentials in multiple sclerosis.

Power spectral analysis (PSA) was performed on the visual evoked potentials (VEPs) to counterphased checkerboard stimuli from 98 eyes in 49 patients with multiple sclerosis (MS) and 54 eyes of 27 normal volunteers. Attenuation of high frequency components of the transient visual evoked potential was found in 53% of MS patients and 4% of controls. Loss of high frequency components was poorly correlated with prolonged latency (r = 0.346). The consideration of both PSA and latency of the VEP increased the percentage of MS patients exhibiting visual pathway conduction abnormalities from 61% to 86%. The use of PSA in the diagnosis of MS is useful in increasing detection especially in cases where deformed waveforms preclude a reliable estimation of latency.

Adult↗

PubMed1982

Analysis of the effect of temporal frequency on the dichoptic visual-evoked response.

When observers with normal binocularity view reversing black and white checkerboard patterns, the amplitude of the resulting binocular visual-evoked response (VER) is significantly greater than the amplitude of either corresponding monocular response. When the same checkerboard pattern is dichoptically presented with an interocular luminance difference (1.3 to 2.0 log units), the amplitude of the dichoptic VER is significantly less than either monocular response. In a previous study, we attributed this effect to interference between the monocular components of the binocular response resulting from a phase shift induced by the interocular luminance difference. To test this hypothesis, dichoptic VER's were recorded for three temporal frequencies (1.88, 3.75, and 7.5 Hz). The results obtained support the phase shift interpretation.

Adult↗

PubMed1982

The contribution of the central retina to the laser speckle visual evoked response.

Laser speckle stimuli were used to examine the contribution of the central retina to the visual evoked response (VER). The foveally fixated test stimuli were either small circular spots or annular targets with dark centers. The speckle elements were shifted seven times per second. Reliable responses could be recorded for even the smallest (1 degree) target size. In addition, it was clearly evident that for spots up to 5 degree in diameter, VER amplitude increased linearly with stimulus area. However, data from annular targets revealed that this result was not strictly dependent upon stimulus area. In many instances, large annular stimuli evoked responses with smaller amplitude than spot stimuli with less area. This result may be due to a center-surround antagonistic interaction. These experiments suggest a potential value for laser speckle VER techniques in the assessment of discrete lesions of the macula.

Evoked Potentials, Visual↗

PubMed1982

Interocular luminance differences and the binocular pattern-reversal visual-evoked response.

Although the visual-evoked response (VER) is frequently used to assess binocularity, the contribution of the monocular components to the binocular VER is poorly understood. To more fully elucidate this relationship, we examined checkerboard (14 min arc checks) pattern-reversal (3.75 Hz) VERs evoked from observers with normal binocularity, with conditions in which interocular luminance differences (from 0.3 to 2.0 log units) were established. When compared with monocular VERs obtained with similar luminances, the binocular response was always less than the sum of the component monocular responses. In addition, the amplitude of the binocular signal was dependent on the amount of interocular luminance the difference. For interocular luminance differences of less than 0.6 log units the amplitude of the binocular response was consistently greater than either corresponding monocular VER. When the interocular luminance difference was 1.3 log units or greater the amplitude of the binocular response fell below the level of either corresponding monocular response. Furthermore, it does not appear that these results can be attributed to a passive spread of electrical potentials from monocular cortical cell populations. We therefore suggest that these results indicate the activity of a binocular neural process.

Adult↗

PubMed1982

Spatial and temporal frequency tuning of pattern-reversal retinal potentials.

Pattern-reversal retinal potentials (PRRPs) are electrical signals generated within the human retina, possibly by the retinal ganglion cells, when a phase-alternating checkerboard pattern (or grating) is viewed. This study systematically examined the effects of varying the spatial and/or temporal frequency of the stimulus pattern on the resulting PRRP. A significant variation in PRRP amplitude, which was dependent on both the spatial and temporal frequency of the stimulus, was observed. Optimum response amplitude was obtained with a low spatial frequency (0.250 cy/deg) at intermediate temporal frequencies (3.75 or 7.50 Hz). A linear regression, fit to the average PRRP amplitude vs. spatial frequency data for either the 1.88 or 3.75 Hz conditions, appears to predict average subjective visual acuity.

Adult↗