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Biomedical subjects

G Kreuzer

Publications and source records attributed to G Kreuzer.

32 records · Page 2Linked to original sources
PubMedDate not supplied

Aspiration biopsy cytology, mammography and clinical exploration: a modern set up in diagnosis of tumors of the breast.

Six hundred and two mammary tumors were examined clinically, by mammography and cytology, with a histologic checkup following surgical biopsy. There were 247 cases of malignoma and 355 benign cases. The limited reliability of the individual methods is demonstrated, and it is shown that their combined use can improve the diagnosis. More malignomas are detected, and preoperative diagnosis is made more safely. If all three methods yield identical results, as was the case in 50.2% of the malignant and 32.7% of the benign lesions, the probability of diagnostic error is less than one per cent. With a malignoma thus established, surgical treatment may follow immediately, or irradiation can be started. In benign cases a surgical biopsy may be foregone and further developments may be awaited with due provision for regular control. If the three methods yield conflicting or doubtful results, elucidation by surgical biopsy and histology is indicated.

Biopsy, Needle↗
PubMedDate not supplied

Aspiration biopsy cytology in proliferating benign mammary dysplasia.

The accuracy of the cytologic diagnosis from needle biopsy in proliferating mammary dysplasia was tested on the basis of 101 histologically proven cases of mild to severe degree. The cytomorphologic presentation in smeared aspirate is described. A reliable cytologic diagnosis of proliferating mammary dysplasia was possible in about half of the cases. This implies that the fine-needle biopsies give new possibilities for detection and intensive surveillance without surgical biopsies of women with increased risk of developing breast cancer. Study of the individual cases showed that the more severe the proliferation of the mammary epithelium, the greater the accuracy of the cytologic diagnosis. In intraductal and intracystic proliferation the accuracy was higher than in pure adenosis.

Biopsy, Needle↗
PubMedDate not supplied

Feulgen-DNA-cytophotometry on mammary tumor cells from aspiration biopsy smears.

The nuclear DNA content of cells from 20 cases of mammary aspirates was estimated by microspectrophotometry. Smears stained according to Papanicolaou were destained and Feulgen-reacted. Among the smears there were 14 with doubtless tumor cells, four with a benign cell picture, and two of a doubtful nature. The mammary lesions were in all cases verfied by histology. Measurements showed that smears of benign tumors had a diploid or diploid to tetraploid distribution of DNA. The two doubtful smears also showed the same DNA pattern, although in one case the cells were from a papillary carcinoma and in the second case from a fibroadenoma. Malignomas with a cell picture, monomorphous-atypical in Papanicolaou staining exhibited a DNA histogram with a peak in the diploid to hyperdiploid ranges. Carcinomas showing a polymorphous-atypical cell picture were characterized either by polyploid values, by a large spread, or by aneuploidy. Hence, it is impossible to safely distinguish benign cases from carcinomas by the DNA pattern, since DNA distribution is fairly identical in part of the cases in either group.

Adenofibroma↗