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Biomedical subjects

G Kretschmer

Publications and source records attributed to G Kretschmer.

At least 127 records · Page 7Linked to original sources
PubMed1981

[Sparks grafts as arterial substitutes in the femoro-popliteal region with a postoperative follow-up of up to 54 months].

39 Sparks-Mandril grown grafts were implanted as arterial substitute in the femoropopliteal region and followed up for a minimum of 36 and a maximum of 57 months. At 7 instances it was not possible to perform the connecting procedure, 18.7% immediate occlusions, 28.2% early failures within the first postoperative year, 12.5% pseudoaneurysmal changes were noted. 13 patients (40.6%) demonstrated function for more than one year. Dilatation, elongation and parietal thrombosis over the whole length of the graft (2 cases) and late reocclusion turned out to be the main problems. Only 2 patients carry a properly functioning graft.

Aged↗
PubMed1978

Left ventricular pump failure associated with diffuse coagulation in experimental intraoperative autotransfusion.

Autotransfusion of blood from the peritoneal cavity of pigs under a regimen of acid citrate dextrose solution 1:10 v/v for reservoir anticoagulation or systemic heparinization with 300 Iu/kg did not affect cardiac performance. Rapid deterioration of left ventricular pump performance was observed when low dose systemic heparin 100 Iu/kg was used. Evidence suggests that this is related to diffuse coagulation.

Animals↗
PubMed1976

[Blood coagulation disorder, hemolysis and hypoalbuminemia after autotransfusion in experimental intraperitoneal hemorrhages].

Autotransfusion in a canine model (n = 15) causes anemia, thrombocytopenia, hypofibrinogenemia, hypalbuminemia, and metabolic acidosis and enhances elimination of intravenously injected 131I albumin. Contact of the shed blood with the peritoneal surface aggravates the pathologic findings; without simultaneous intraperitoneal heparinization the highest rates of hemolysis with concomitant oliguria were observed.

Acidosis↗
PubMed1975

[Hypoglycaemic coma in Boeck's sarcoidosis (author's transl)].

The diversity of clinical manifestations of Boeck's sarcoidosis may also include endocrine disorders. One year after diagnosis of sarcoidosis in a 29 year-old female patient, endocrinological complications became manifest with amenorrhoea. The course of the disease was additionally complicated by hypoglycaemic episodes. Thorough clinical investigation of the patient revealed sarcoid involvement of the skin, lungs, liver and lymph nodes and an extensive retroperitoneal surgically-verified lymph tumour. After tolbutamide and in reaction to an intravenous glucose tolerance test the blood glucose was found to be very low, whilst the immunoreactive insulin was normal. Further investigation of the endocrine functions of the patient revealed normal functioning of the thyroid gland, subnormal values for the follicle stimulating hormone and extremely low serum ACTH and serum cortisol values, without any diurnal changes in these parameters. The clinical symptoms of the patient and the biochemical findings were regarded as manifestations of secondary adrenal failure due to sarcoid involvement of the hypothalamus and pituitary. Hence, treatment with corticosteroids was started. Hypoglycaemia has not since been observed in this patient and the other clinical features of (secondary) adrenal failure have disappeared slowly.

Adrenocorticotropic Hormone↗
PubMed1975

Secretin-induced bile secretion, bile acid output and blood supply to the liver in the dog.

Bile secretion and blood flow in the portal vein and the hepatic artery were determined in cholecystectomized anesthetized dogs before and during continuous infusion of varying doses of secretin. Secretin increases bile volume without alteration of bile acid output. Hepatic arterial flow was not altered by any dose. However, high doses of secretin increased portal venous blood flow significantly. It is concluded that secretin action on liver blood flow mirrors mainly superior mesenteric arterial vasodilation and seems to be a rather pharmacologic than a physiologic response. Bile secretion is not influenced by changes of hepatic blood flow in the physiologic range.

Animals↗