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Biomedical subjects

G Kreil

Publications and source records attributed to G Kreil.

102 records · Page 6Linked to original sources
PubMedDate not supplied

Deltorphin, a naturally occurring peptide with high selectivity for delta opioid receptors, improves memory consolidation in two inbred strains of mice.

Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, with DBA mice being more sensitive to this effect. The results show different effects of delta and mu receptor agonists on memory consolidation and of strain differences in number and/or distribution of delta opioid receptors in the brain.

Analysis of Variance↗
PubMedDate not supplied

The cytoplasmic carboxy terminus of M13 procoat is required for the membrane insertion of its central domain.

The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, block membrane assembly, while insertion of three lysyl residues near the carboxy terminus partially restores assembly. Thus the information specifying membrane insertion of M13 procoat protein is found in its mature region as well as the leader and is not simply decoded in an amino to carboxy direction.

Amino Acid Sequence↗