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Biomedical subjects

G Koren

Publications and source records attributed to G Koren.

At least 667 records · Page 37Linked to original sources
PubMed1983

Kinetics of CSF phenytoin in children.

The efficacy of intravenous phenytoin for the treatment of status epilepticus is related to the rapid entry of phenytoin into brain parenchyma. There is no information concerning the correlation between phenytoin serum and CSF concentrations in children, and the application of CSF data to clinical use. We report 7 children (2-11 yrs) who were treated or exposed to phenytoin in doses between 10.5-230 mg/kg. Lumbar puncture was performed 9 times in 6 of the patients. In one patient, an intraventricular catheter permitted successive assessment of CSF phenytoin concentrations. The ratio of CSF/serum phenytoin concentrations was 0.16 +/- 0.08, with gradual increase over the first 8 hours as the serum phenytoin concentration decreased. There was good correlation between therapeutic outcome and CSF phenytoin levels higher than 2 mcg/ml. In one patient the coma state secondary to phenytoin intoxication was associated with high CSF concentration (6 mcg/ml).

Age Factors↗
PubMed1983

Digoxin-amiodarone interaction: in vivo and in vitro studies in rats.

Amiodarone is a new antiarrhythmic drug, commonly coadministered with digoxin in various cardiac disorders. Amiodarone caused a 10-fold increase of serum digoxin in rats, when the two drugs were simultaneously administered. Amiodarone significantly reduced digoxin uptake by renal cortical slices in the rat, and failed to reduce digoxin uptake by either heart or diaphragmatic muscle. The inhibition of the renal tubular uptake of digoxin caused by amiodarone may explain in part the increased serum digoxin concentration observed in vivo. Close resemblance was found between the mechanisms involved in the amiodarone-digoxin interaction, and those of digoxin interaction with either quinidine or verapamil.

Amiodarone↗
PubMed1983

Constrictive pericarditis following coronary-artery bypass grafting in a patient with chronic asymptomatic pericardial disease.

Constrictive pericarditis is a rare complication of open-heart surgery. We describe a patient who was found at the time of coronary artery bypass surgery to have asymptomatic pericardial thickening and subsequently developed rapidly progressive constrictive pericarditis. At operation for pericardiectomy, the bypass graft to the posterior descending coronary artery was found to be strangled by fibrous tissue while the remaining two bypass grafts were patent. Following pericardiectomy, the patient made a good recovery.

Chronic Disease↗
PubMed1982

Reversible hypertrophic osteoarthropathy associated with cyanotic congenital heart disease.

We treated two patients with congenital cyanotic heart disease (CCDH) in whom associated hypertrophic osteoarthropathy (HOA) developed. Both were severely cyanotic and hypoxic for many years before HOA was fully manifested. Clinical and roentgenographic indications of bone and joint lesions disappeared completely shortly after corrective of palliative surgery. There appears to be an etiologic connection between HOA and CCHD.

Adolescent↗
PubMed1979

Semiquantitative determination of liver specific antigen in the urine or rats with toxic hepatic necrosis.

Using Mancini's single radial immunodiffusion technique, the excretion of a liver specific saline soluble antigen was semiquantitatively assayed in the urine of rats with thioacetamine induced hepatic necrosis. The relative amounts of antigen detected in the urine were found to roughly correlate with the extent of necrotic liver parenchyma. It is suggested that a quantitative approach to histuria may provide clinically relevant information on the activity of pathologic processes associated with release of organ specific antigens from degenerative and necrotic lesions into the circulation (histemia) and thence into the urine.

Animals↗