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Biomedical subjects

G Kolarz

Publications and source records attributed to G Kolarz.

At least 91 records · Page 5Linked to original sources
PubMed1977

Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis.

In the present investigation the occurrence of humoral immunity to pancreatic duct cells (PDC) was studied in 12 patients with Sjögren's syndrome (SS), 31 patients with rheumatoid arthritis (RA), and 64 controls. Four sera of patients with SS and eight of patients with RA produced diffuse cytoplasmic fluorescence of intro- as well as of interlobular PDC of human and rhesus monkey origin. All sera positive with PDC antigens gave also positive staining reaction with parotid, submandibular, and lacrimal duct cells. In absorption studies antibody activity to PDC and salivary duct cells could be absorbed equally well with human or monkey parotid gland or pancreas with almost identical antigen concentrations. These findings point to the presence of common antigenic determinants in the organs studied. Human thyroid microsomes and rat liver homogenate did not reduce antibody activity. The demonstration of antibodies to PDC in addition to the reported mononuclear cell infiltration of the pancreas point to the involvement of autoimmune mechanisms in pathogenesis of the commonly observed subclinical exocrine insufficiency in SS and in some cases of RA.

Animals↗
PubMed1977

[Systemic manifestations in rheumatoid arthritis. A multivariate analysis of 122 patients (author's transl)].

In a retrospective study the case reports of 122 patients with rheumatoid arthritis (RA), were analyzed by computer with respect to systemic manifestations and the possible relationship of these manifestations to clinical findings. Bromsulphthalein retention, lung and kidney function were studied in other smaller unselected groups of RA patients and the results compared with the relevant clinical data. It was observed that nearly all systems can be involved in RA. High rheumatoid factor titres seem to be of great importance with regard to prognosis, but the duration and activity of the disease do, however, also influence the occurrence of systemic complications. Functional impairment of the different organs investigated was found in a high percentage of RA patients. Usually these disturbances are subclinical and not of great significance to the patient. Effects of antirheumatic drug therapy are difficult to evaluate, but they obviously do play an important role in the aetiology of the observed functional disturbances. Nevertheless, it must be stressed that the detection of systemic manifestations and functional disorders at the earliest possible stage of the disease is needed in the determination of the therapy of choice and is of great prognostic importance, thereby justifying detailed and often costly investigation.

Adolescent↗
PubMed1977

[Investigations of the final settling of implanted hip-joints by use of 85Sr (author's transl)].

Up to 8 years after replacement of hip-joints in 26 patients the strontium-85-uptake over both thighs was followed scintimetrically. In contrary to normal healing of fractures, this uptake became normal on the side of the operation not earlier than the end of the 2nd year after operation. One cause of this delay could be the continuing liberation of monomeres of polymethyl-methacrylates at the bed of the implant. It is important to consider the clinical signs on the opposite side, since there a raised strontium-85-uptake could produce a "pseudo"-diminished ratio between the two sides.

Aged↗
PubMed1976

Pertechnetate uptake of joints in rheumatoid arthritis.

A new isotopic method for evaluation of inflammatory activity in rheumatoid arthritis is reported. By use of repeated whole body profile scanning a double tracer examination with 99mTc-pertechnetate and 113mIn-transferrin was performed. Total pertechnetate activity and total indium activity were measured over both hands, both feet, the ankles, and over the knee joints. In addition, the extravascular component of pertechnetate uptake and the ratio extravascular/total pertechnetate activity were calculated for these regions. The activity curves were followed up to 2 h after tracer injection in seven female patients presenting with rheumatoid arthritis and in six female controls. The four parameters calculated were compared and statistical analysis revealed the most significant discrimination of both groups for the ratio extravascular/total pertechnetate activity 2 h after injection (P less than 0.002).

Aged↗
PubMed1976

[The implementation of a computerized documentation system for the evaluation of spa therapy in patients with rheumatoid arthritis (author's transl)].

A previously-described documentation system for articular examination was applied to evaluate the results of spa treatment in 20 patients with rheumatoid arthritis during 3 separate treatment periods. Physical joint findings were documented and indices were compiled by means of a computer before, during and after treatment with thermal water the first year, normal water the second year (or vice versa) and without baths at all in the third year. These indices were compared statistically. Each kind of treatment produced a statistically-significant improvement in the disease, there being no significant difference in the results achieved by the 3 therapeutic regimens.

Arthritis, Rheumatoid↗
PubMed1976

Seropositive rheumatoid arthritis associated with decreased diffusion capacity of the lung.

Sixty-two patients with classical or definite rheumatoid arthritis were subjected to lung function analysis. The various parameters--spirography, plethysmography, blood gas analysis, measurement of lung compliance, and diffusion capacity--were correlated with duration and stage of disease, and with rheumatoid factor titres. A statistically significant correlation was found to exist between Rose-Waaler titre and specific diffusion capacity. Similar results between Rose-Waaler titre and lung compliance, however, were not statistically significant.

Adolescent↗
PubMed1976

Influence of diftalone on tolbutamide test and i.v. glucose tolerance test.

In 16 healthy volunteers tolbutamide tests or i.v. glucose tolerance tests were performed with and without previous oral administration of 1000 mg diftalone. Blood sugar and serum insulin were assayed in regular intervals. Both with and without previous administration of diftalone blood glucose after tolbutamide did not show any difference. IRI response to tolbutamide, measured by planimetrical integration showed a statistically significant augmentation (0.05 greater than p greater than 0.01) after diftalone. Glucose assimilation (K-value) after diftalone was decreased (0.05 greater than p greater than 0.01) yet within normal range. For the accompanying insulin levels however no statistically significant difference was observed. In addition a normalisation of pathological tolbutamide test after diftalone could be noted in five patients with subclinical diabetes. Our results indicate that diftalone seems to have the following three actions: 1. Enhancement of the tolbutamide action. 2. direct augmentation of IRI secretion, 3. a peripheral action on glucose metabolism.

Adult↗
PubMed1976

[X-ray documentation of the anamnesis and physical data in patients with rheumatism within the scope of the medical information system WAMIS].

A computerized on-line system of evaluating of symptoms and physical data in rheumatology is presented. Case history, previous treatment, and physical examination are documented. The documentation of the latter may be performed in two ways: one records only joint symptoms, the other includes joint measurements. In comparison to the former off-line method, all data are much better available. Moreover, we believe it to be considerably timesaving. This system should also allow an electronic differential diagnosis of rheumatic diseases, after completing laboratry and X-ray documentation.

Austria↗
PubMed1976

[Therapy evaluation in rheumatology with an electronic data processing system].

A system for the evaluation of therapeutical effects in rheumatic diseases is presented. This system permits a calculation of two indices: i.e. rheuma-number and "Masszahl" (= only measured values such as range of motion in degrees) which lend themselves to statistical treatment. The result of standardized physical joint examination of patients is recorded on two mark-pages, specially developed for documentation of joint status. The data recorded on the two-mark-pages are then entered into the computer by means of a mark-page-reader. On the basis of these data, the computer, upon the basis of a program specially developed for this purpose, automatically calculates the corresponding amount of negative-points, which parallels the severity of the joint changes, i.e. the rheuma-number ("Rheumazahl"). Separately listed at the end of the status-outprint is the "Masszahl", which is part of the rheuma-number and comprises the measured values (for example, the range of motion measured in degrees). The practicability of this system is demonstrated on the basis of the results of a double-blind-comparison of two antirheumatic-corticosteroid-combinations and an open study with immuno-suppressives in patinets with rheumatoid arthritis.

Anti-Inflammatory Agents↗
PubMed1976

[Technetium uptake in the parotid gland. Value of functional parameters in Sjögren's syndrome].

Studies of the parotid function were performed on 22 subjects comprising 11 patients with Sjögren's syndrome and 11 normal controls using an Anger camera with digital data processing facility. After injection of 2 mCi of 99mTc-pertechnetate digital scintigrams of the face region were collected and stored onto magnetic tape. 50 minutes after injection the parotid glands were stimulated by administration of Pilocarpin. By subsequent processing of the data uptake curves were obtained for both parotid glands. In allowing for vascular activity three different methods were compared. The most satisfactory method with respect to discriminating the groups under study was using a background region located in the falx cerebri. From the corrected uptake curves a number of parameters were derived and their respective selectivity was investigated by statistical analysis. It is shown that the most suitable parameter characterizing the parotid function is given by the difference of maximum uptake before Pilocarpin stimulation and minimum uptake after stimulation.

Humans↗