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Biomedical subjects

G Kober

Publications and source records attributed to G Kober.

At least 217 records · Page 12Linked to original sources
PubMed1977

[Clinical light and electron microscopic findings in patients with late and early congestive cardiomyopathies (author's transl)].

Right of left ventricular biopsies were performed in 50 patients with late and early forms of congestive cardiomyopathy. Clinical data as well as light and electron microscopic findings are described. Chronical myocarditis could be detected by histological examination in three patients. Hypertrophy and degenerative changes of the heart muscle cells and interstitial fibrosis were the major morphological finding in the other cases. There is a good correlation between the severity of clinical symptoms and the extent of light and electron microscopical changes. In some patients with mild clinical symptoms advanced ultrastructural alternations were found.

Biopsy↗
PubMed1976

[Coronary arteriography in patients with Prinzmetal's angina associated with ST elevations (author's transl)].

Among 1000 patients with coronary heart disease studied at rest and on exercise and by coronary arteriography, 17 had ST elevations during the anginal episodes. ST changes during exercise occurred in 16 patients, 12 of whom had spontaneous angina. One patient had ST changes only during spontaneous attacks at rest. Critical proximal lesions in the descending branch of the left anterior coronary artery were revealed by coronary arteriography in all 17 patients. Biplane ventricular cine-angiography revealed slight abnormalities in 12, normal pattern in the other five. It is thought that ST elevation during anginal attacks is caused by severe transmural ischaemia. Spontaneous attacks are thought to be due to additional functional narrowing, probably resulting from an increased vascular tone within the area of obstruction.

Angina Pectoris↗
PubMed1976

[Surgical treatment of ventricular aneurysm: an analysis of post-resection haemodynamic changes (author's transl)].

Of 500 patients with angiographically proven myocardial infarction 75 had a left ventricular aneurysm. 25 of them subsequently had resection of the aneurysm. Postoperative studies revealed marked improvement of symptoms. Pulmonary arterial pressure was significantly decreased at rest (from 28 to 20 mm Hg) and on exercise (from 58 to 35 mm Hg). There was a reduction in left ventricular end-diastolic volume (from 247 to 1.54 ml/1.73 m2) and a raised ejection fraction (from 36 to 59%). Good results were obtained especially in those patients who had congestive heart failure due to paradoxical systolic expansion of the ventricular wall and (or) secondary reversible damage in the remaining viable myocardium. Left ventricular aneurysms should be suspected after myocardial infarction when there is left ventricular failure and an increase in heart size.

Adult↗
PubMed1976

[Volume parameters of the right and left ventricles in coronary disease with and without myocardial infarct].

In 58 patients (pts) with coronary heart disease volume parameters of both ventricles were determined from two angiograms . Four groups of pts were formed according to localization of left ventricular damage: group I (24 PTS) without myocardial infarction, group II (17 pts) with anterior wall infarction (AWI), group III (9pts) with inferior wall infarction (IWI), and group IV (8 pts) with AW and IWI. In group I enddiastolic volume (EDV) of the left ventricle (LV) was 135 +/- 61 ml/1.73 m2, of the right ventricle (RV) 145 +/- 62 ml/1.73 m2, the ejection fraction (EF) 74% (LV) and 66% (RV). In group II EDV of LV increased significantly (194 +/- 88) and EF decreased to 50%, whereas EDV and EF of RV remaine unchanged. In group III EDV (LV 160 +/- 46, RV 172 +/- 95) of both ventricles was increased and EF (LV 57%, RV 58%) decreased, In group IV a more pronounced increase in EDV (LV 218 +1- 58, RV 181 +/- 30) and decrease in EF (LV 46%, RV 48%) was seen. A disturbance in contraction of RV was observed only in cases with IWI of LV. In contrast to LV, a diffuse impairment of RV occured. It was assumed that in RV disturbances in contraction exceeded the extent of scarred areas which might be explained by partially reversible ischemic disturbances of function.

Cardiac Catheterization↗
PubMed1976

[Nitroglycerin in the therapy of coronary insufficiency and heart failure].

In the treatment of angina pectoris nitroglycerin is still the most important drug. Its mechanism of action is described in reference to the lowering of preload and afterload as well as to the question of redistribution of regional myocardial blood flow. It is shown that after oral administration of issosorbide dinitrate effects on myocardial ischemia and left ventricular filling pressure can be seen lasting over more than four hours. In the treatment of acute myocardial infarction and left ventricular failure nitroglycerin can be used with favourable results and without undesired side effects if the hemodynamic is carefully observed. Under these conditions the intravenous infusion seems the most appropriate way of administration.

Administration, Oral↗
PubMed1976

[Angiography of left ventricle following volume load and physical work in coronary disease].

In order to recognize and quantitate abnormalities in wall segment motion in 22 patients simultaneous measurements of isovolumic and ejection phase parameters were performed with the Millar-angiographic catheter at rest, after leg raising and during bicycle exercise. 6 patients had slight coronary heart disease (CHD) (group I), 16 patients had severe CHD (group II). During volume load in all patients of gr. II a decrease of peak measured velocity (Vpm) and the velocity of circumferential fiber shortening (Vcf from 1.4 to 1.1 circ/s, p less than 0.025) occurred. In gr. I Vcf increased (p less than 0.05). During exercise there was a high increase in Vpm and Vcf in gr. I (from 1.2 to 1.9 circ/s) whereas in gr. II no increase was observed. LVEDP rose to 29 mm Hg and ESV from 58 to 70 ml/1.73 m2. By increasing LVEDP during volume load underperfused areas became ischaemic and akinetic. During physical work the segmental abnormality can be less pronounced possibly due to the higher prestenotic pressure.

Angiocardiography↗
PubMed1975

[Effect of digitalis on contractility of the failing right and left ventricles during exercise (authors transl)].

Intra-venticular pressures were measured at rest and during simulated exercise before and after intravenous administration of 0.6 mg beta-methyldigoxin in 16 patients (right ventricular measurements in 11, left ones in five), measurements in the right ventricle being taken before and 30-45 min after, in the left ventricle before and 20 min after injection of the drug. There was an increase in stroke volume and maximal cardiac work, while end-diastolic pressure fell. Cardiac glycosides can, therefore, favourably influence congestive cardiac failure on physical exertion. Digitalization indicated in those patients who, on exercise, have an increased end-diastolic pressure and reduced contractility. The positive digitalis effect consists of improved contractility and sustained reduction in end-diastolic pressure. On maintenance digitalization it is to be expected that the heart will profit from both mechanisms, both at rest and during exercise. The increased contractility caused by the glycosides is, however, so small that it does not cause any significant change in oxygen consumption.

Blood Pressure↗
PubMed1975

[Pre- and postoperative investigations of patients after aortic valve replacement with prosthetic valves or homografts (author's transl)].

Two groups of patients with aortic-valve disease were compared. Group I (18 patients) received prosthetic valves, group II (12 patients) homograft valves. The symptoms and haemodynamic findings improved in both groups, postoperatively. Complications were more frequent with prosthetic than homograft valves, and the haemodynamic responses also were better in the homograft group, especially during exercise.

Adult↗