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G Knutsen

Publications and source records attributed to G Knutsen.

25 records · Page 2Linked to original sources
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Failure of methapyrilene to induce tumors in hamsters or guinea pigs.

In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage twice a week for 78 wk with a 200-mg/kg body weight dose of methapyrilene hydrochloride dissolved in water, a total dose of approximately 30 g/kg body weight. By the end of the treatment more than half of the animals were still alive: survivors were killed at 132 wk. A group of 20 male Syrian golden hamsters was treated twice a week by gavage with 15 mg methapyrilene hydrochloride for 58 wk, a total dose of approximately 15 g/kg body weight. Thirteen animals survived an acute convulsant effect, and the last 4 were killed at wk 61. There was no significant incidence of any tumor that could be attributed to the treatment in either guinea pigs or hamsters.

Aminopyridines↗