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Biomedical subjects

G Kliems

Publications and source records attributed to G Kliems.

31 records · Page 2Linked to original sources
PubMed1979

[The value of lung biopsy in the radiological stage of bihilar adenopathy of sarcoidosis (author's transl)].

The classification of intrathoracic sarcoidosis into stages is based on radiological criteria. As pulmonary involvement is often considered to be an indication for corticosteroid therapy a comparison was made between the X-ray picture and lung biopsy in stage I sarcoidosis. Non-caseating epitheloid granulomas were found in 9 of 12 patients. The material was obtained by open biopsy in 8 patients and by the transbronchial approach in one case. Open and transbronchial biopsy failed in 3 patients to demonstrate sarcoid granulomas. The results suggest that the presence of mottling in the chest roentgenogram does not provide the rationale for treatment. Further studies will show whether irreversible damage to lung tissue could be prevented if lung biopsies were taken and, consequently, steroid therapy initiated, at an earlier stage of the disease.

Adult↗
PubMed1978

[About the comparison of closely related species chimpanzee-man and fox-dog in respect of the possibility of xenotransplantation (author's transl)].

Although the transplant combinations chimpanzee-man on one hand and fox-dog on the other hand have nearly the same phylogenetic development within their zoological family, it is not quite correct to compare the immunological reactions and patterns of rejection of xenogeneic transplants within these systems. The differences in immunochemistry of serum proteins between these two systems confirm that chimpanzee and man are more closely related than fox and dog concerning their genetic disparity. This and other mentioned examples demonstrate the possibility of obtaining qualitative informations of genetic constellations between xenogeneic species combinations by comparing immunochemistry of serum proteins.

Animals↗
PubMed1978

[Immunobiological fundamentals of primary graft rejection (author's transl)].

Graft rejection caused by genetic differences between donor and recipient is an immunological reaction of transplantation antigens with mechanisms of primarily cellular immunity, and later on even of humoral immunity. For initiating the immune response of the recipient three stages have to be distinguished: 1. Recognition of determinant groups of transplantation antigens by menbrame receptors at the surface of immunologically competent lymphocytes. 2. Differentiation and proliferation of immunologically activated lymphoid cells into cellular antibodies and plasma cells, the receptor molecules of which could be identified as immunoglobulins and which are sent into the blood as circulating humoral antibodies, , partially as complement fixing ones. 3. Effector phase, in the course of which the lysis of the graft is caused by target cell destruction. Many problems still remain unsolved, but now as ever, the basis of most experimental studies is still formed by Burnet's clonal selection theory.

B-Lymphocytes↗
PubMed1978

[The effect of acute liver damage on inactivation of renin and aldosterone (author's transl)].

Plasma renin activity was measured in 5 surgical patients with hydatoid disease of the liver before and after partial hepatectomy. Plasma renin activity rose statistically significantly after surgical operation and remained virtually constant thereafter. This rise was accompanied by a statistically significant rise of plasma aldosterone while urinary excretion of aldo-18oxo-glucuronid remained unchanged. No change of urinary excretion of electrolytes was observed. It is concluded that besides stress after surgical operation decreased hepatic inactivation of renin and aldosterone were the main causes which led to elevation of plasma aldosterone concentration.

Aldosterone↗
PubMed1977

[Available methods to modify primary graft rejection (author's transl)].

Primary graft rejection is an immunological reaction. Many modes of preventing, or at least, delaying rejection have already been tested. The present study deals with experiences and possible mechanisms of action of nonspecific immunosuppression caused by different drugs or antilymphocytic sera; furthermore, an account is given of the latest stand of knowledge gained from experimental studies to induce immunological enhancement, as well as immunological tolerance to transplantation antigens.

Animals↗