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Biomedical subjects

G Kimmerle

Publications and source records attributed to G Kimmerle.

36 records · Page 2Linked to original sources
PubMed1976

Toxicity of propoxur to rats by subacute inhalation.

Male and female rats were exposed to propoxur (2-isopropoxyphenyl-N-methyl-carbamate) aerosol, concentrations averaging 5.7, 18.7 and 31.7 mg/m3 air, for 6 hours daily on five days in a week over a period of 12 weeks. The effects were depressions of plasma by 20 to 30%, and of erythrocyte and brain cholinesterase activities which were caused by the highest air concentration of 31.7 mg/m3. On the basis of the physical, biochemical, phamacokinetic and metabolic behaviors of propoxur, a maximum allowable concentration of 2.5 mg/m3 air is suggested.

Aerosols↗
PubMed1975

[The inhalation toxicity of tertiary butylisonitril in rats and mice. Acute toxicity and evaluation of embryotoxic and mutagenic effects (author's transl)].

The inhalation toxicity of tertiary butylisonitril (TBIN) was evaluated in rats and mice. In addition, pregnant rats were exposed to TBIN aerosols to test its embryotoxic effects and male mice were exposed to TBIN aerosols to evaluate its mutagenic effects using the dominant lethal test. Inhalation of TBIN aerosols caused death in rats only at high concentrations. The following inhalation LC50 values were determined for rats and mice following inhalation of TBIN aerosols: 4-hr exposure: male rats 715, female rats 710, male mice 377; five 4-hr exposures: male and female rats between 356 and 583 mg/m-3 air. The animals were impaired for a long period of time, and death occurred up to 10 days after the exposure. Female rats were exposed to TBIN aerosols from the 6th to the 15th day of gestation daily for 4 hrs. The used concentrations were not toxic to the pregnant rats. It became evident that only the lowest concentration (14 mg/m-3) was not effective to the development of the fetus. A TBIN concentration of 36 mg/m-3 definetely increased the resorption in embryos, and with 71 mg/m-3 a complete loss of the fetus occurred due to resorption. A teratogenic effect could not be determined. A single 4-hr inhalation of 125 mg TBIN/m-3 air caused changes of the sperms of male mice. There was a decreased fertilization capability during the first week of mating after the exposure and a decreased implantation rate with a simultaneous increase of pre-implantation losses in the females. With respect to industrial hygiene it is important that concentrations of TBIN in the air show embryotoxic and anti-spermatogenic effects in animals, which they tolerated without symptoms of poisoning.

Aerosols↗
PubMedDate not supplied

Inhalation studies with polyurethane foam dust in relation to respiratory tract carcinogenesis.

Male and female Sprague-Dawley rats were exposed to freshly generated polyurethane foam dusts, in concentrations averaging 8.65 mg/m3 air, for 6 hours daily 5 days a week over a period of 12 weeks. For comparison the same numbers of rats were exposed to titanium dioxide (TiO2) (15.95 mg/m3 air), which is a known inert dust, and to air alone, as controls for the same exposure period. This exposure caused no noticeable changes in appearance, behavior, or body weight. The average lifespan values were within the normal range. A high tumor rate was seen in all groups, with no significant differences among the groups. No indications of a carcinogenic effect of the inhaled dusts on the respiratory tract could be established. The numerous tumors found in the different organs and groups were of a spontaneous nature. The observed lung-reactions are discussed.

Animals↗