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Biomedical subjects

G Kh Bozhko

Publications and source records attributed to G Kh Bozhko.

At least 19 recordsLinked to original sources
PubMed1996

[The action of high-intensity light on catecholamine excretion in depressive patients].

The action of bright light (2600-2800 lux) on the catecholamine (CA) excretion was analyzed in patients with anxious (11) and melancholic (12) depressions resultant from manic-depressive psychosis and schizophrenia. The melancholic depressed patients were characterized by decreased noradrenaline (NA) and increased adrenaline (A) levels; in anxious depression NA and A were increased. The light therapy resulted in decrease of A level but NA level remained invariable in melancholic depression. Meanwhile the tendency to normalization of excretion of both CA was observed in anxious patients after light therapy. The contrary alterations in A/NA ratio as well as its considerable individual fluctuations were observed after light therapy. The A/NA ratio after light therapy depended mainly upon the initial A/NA ratio (the higher or lower ratio compared to control value).

Adult↗
PubMed1995

[Melatonin excretion in patients with depression under the action of light of increased intensity].

The effects of 1 and 10 bright light exposures (2600-8000 lux) on melatonin excretion in patients with melancholic and anxious depressions were examined. Before treatment the increased basic levels of melatonin excretion were observed in patients with anxious depression. Melatonin excretion had been gradually normalized after 1 and 10 sessions of light therapy. The basic melatonin excretion in melancholic depressed patients was low and hadn't been changed after light therapy. Long term effects of light therapy depend upon the initial levels of melatonin excretion: low pretreatment levels increased and high pretreatment levels decreased after the therapy. The authors proposed that bright light exposures stimulated the restoration of adaptive function of pineal gland in depressed patients.

Adolescent↗
PubMed1993

[Effect of ethanol on cholesterol restoration in tissues of the heart and aorta].

The time course (0.5-24 hours) of incorporation of labelled cholesterol in the tissues of guinea pig hearts, aortas, livers, and brains was examined on acute and chronic (3 months) administration of ethanol (3 g/kg). It was found that at the onset of the experiments, the hearts from control and experimental animals displayed higher radioactivity that did the other tissue under study. Within the first 24 hours, there was a linear increase in specific radioactivity of [3H]-cholesterol in the sera of intact animals. Acute and chronic ethanol caused enhanced incorporation of [3H]-cholesterol and its delayed release in all tissues, except the liver tissue. The latter showed unchanged relative specific radioactivity two hours after [3H]-cholesterol incorporation.

Animals↗
PubMed1993

[Redistribution of rabbit blood serum lipoproteins, caused by a one-time administration of cholesterol].

The redistribution of rabbit blood serum lipoproteins following 24-hr incubation of the sera at 37 degrees C and after a single injection of cholesterol (0.2 g/kg) was studied. In both cases there was an increase in the intermediate density (IDL) and low density lipoproteins (LDL) and a sharp decrease in very low density lipoproteins (VLDL). The proportion of the total fraction of high density lipoproteins (HDL) decreased also. The redistribution of the HDL subpopulations against the background of the HDL decline after a single cholesterol dose seems to be due to a relative increase in HDL3 and a decrease in HDL2. The HDL transformation during heat incubation of control sera was accompanied by HDL3 conversion into HDL2. These data suggest that a single cholesterol dose and heat incubation of blood sera stimulate the direct and reverse cholesterol transport. In isolated sera these processes subside gradually. The inhibition mechanism entails the depletion of the lipoprotein system for chylomicrons and VLDL and exhaustion of HDL2. The restoration of the functional potential of the blood lipid-transporting system needs the exchange between lipoproteins and tissues.

Animals↗
PubMed1992

[Periodicity of changes in the concentration of cholesterol and blood serum proteins in dynamics of hypercholesterolemia].

During 30-week hypercholesterolemia in rabbits and guinea pigs the differences in cholesterol dynamics manifested themselves in quantitative variations of blood serum proteins. Five weeks after the beginning of the experiment a sharp increase of cholesterol level corresponded to the equally sharp decrease of the quantity of blood serum total and cation proteins. The variation of protein and cholesterol concentrations in guinea pigs during 17 weeks is similar to the development of early stages of cholesterolemia (4 weeks) in rabbits. It can be supposed that there is a connection between metabolic systems involved in the transformation of blood serum cholesterol and blood serum.

Animals↗
PubMed1991

[The role of acetaldehyde in the effect of alcohol on the central catecholaminergic mechanisms].

Variations in the concentration of noradrenaline (NA) and adrenaline (A) were examined in the hypothalamus, brain stem and cerebral hemispheres under the influence of acetaldehyde and ethanol given alone and combined in single and chronic doses. In some experiments acetaldehyde and ethanol were administered in combination with teturam. The data obtained attest to an important role of acetaldehyde in disturbing the catecholamine mechanisms under alcoholization. As for the hypothalamus, the action of acetaldehyde manifests in the coupling of the two oppositely directed processes--a decrease of NA concentration and a rise of A concentration. In contrast to the other study brain structures, in the cerebral hemispheres acetaldehyde combined with teturam reduces the level of NA and A.

Acetaldehyde↗
PubMed1991

[Acetaldehyde in the cardiotoxic mechanism of action of alcohol: effects on cardiac and adrenal catecholamines].

How the levels of rat cardiac, adrenal, and epinephrine and norepinephrine change with acetaldehyde and ethanol given alone or in combination during their acute and chronic administration was examined. In some series of experiments, acetaldehyde and ethanol were used in combination with teturam. The findings suggest that the coupling of two negative processes--a reduction in cardiac norepinephrine levels, which is associated mainly with the effects produced by ethanol, and an increase in epinephrine concentrations, which is apparently induced by acetaldehyde--may be one of the mechanisms responsible for cardiovascular abnormalities in alcoholic intoxication. Acetaldehyde modifies the regulatory effect of the sympathoadrenal system on cardiac function, causing adrenal catecholamine imbalance.

Acetaldehyde↗
PubMed1991

[Dynamics of the lipoprotein distribution in early hypercholesterolemia characterizes the activation of cholesterol transport].

Using gradient gel electrophoresis, the levels of major classes of rabbit blood sera lipoproteins were studied over a period of 28 days. Hypercholesterolemia persisted up to the 4th day with a subsequent decrease. This was paralleled with an increase in the levels of triglyceride-rich and apoB-containing particles. The decrease of the electrophoretic mobility of low density lipoproteins correlated with an increased content of the intermediate fraction. On the 28th day after the beginning of experiment the concentration of total high density lipoproteins showed an increase. The subfractional redistribution of HDL3 and HDL2 subclasses pointed to the stimulation of the accepting process and the overall reverse cholesterol transport system. A comparison of experimental results with literary data allowed to conclude that the relative decrease of the serum cholesterol level typical of hypercholesterolemia of one month duration is due to the activation of specific and nonspecific preventive mechanisms.

Animals↗
PubMed1991

[Blood lipoproteins in modeling of atherosclerosis and administration of protamine].

The influence of protamine on the HDL, LDL, VLDL species concentration variation as well as on their cholesterol and protein content in respect to total blood serum cholesterol in different periods (1 and 7 months) of hypercholesteremia in rabbits is investigated. Daily administration of protamine (10 mg/kg) during 30 days to intact animals did not change the investigated parameters. In the early period of hypercholesteremia protamine considerably increased the content of all lipoprotein fractions. Under the conditions of prolonged hypercholesteremia the LDL and VLDL concentrations decreased by 23 and 60 per cent, respectively; HDL increased by 101 per cent.

Animals↗
PubMed1990

[Effects of protamine on blood lipoproteins in the early period of hypercholesterolemia in rabbits].

The content of protein, cholesterol and triglycerides in chylomicrons and different classes of blood serum lipoproteins was studied under protamine action in early (1 month) hypercholesterolemia. Except the low density lipoproteins the amount of triglycerides in the particles studied was practically unchanged. The content of proteins in all classes of lipoproteins was greatly increased and this may indicate that protamine activates the blood lipoprotein system. The enrichment of lipoproteins with cholesterol may be taken as being a result of protamine action in early hypercholesterolemia. The peculiar feature in the effect of protamine on mentioned lipoprotein components was that the protein/cholesterol ratio didn't change in chylomicrons, decreased in very low density lipoproteins and low density lipoproteins and increased in high density lipoproteins as compared with controls.

Animals↗
PubMed1990

[The use of medicinal glycerin in treating alcoholics].

The possibilities are shown of using officinal glycerin as a polyatomic alcohol in the treatment of alcoholism, in particular, alcohol abstinent syndrome. The theoretical basis of using glycerin is the possibility of replacing ethanol by a substance with a similar chemical structure not possessing euphoric and narcotic effect. Clinical results showed the rationality of using glycerin as an antialcohol substance.

Administration, Oral↗
PubMed1984

[Serum protein fractions in patients with dyscirculatory encephalopathy in atherosclerosis and hypertension].

Using a novel method of electrophoresis, patients with atherosclerotic and hypertonic dyscirculatory encephalopathy were examined for protein fractions of their blood serum. Various kinds of dysproteinemia and dyslipoproteinemia were recorded, with their manifestations being particularly pronounced in cerebral atherosclerosis with the syndrome of arterial hypertension. Clinical improvement following the therapy was usually accompanied by the normalization of the protein spectrum of blood serum. The results obtained may be utilized in the differential diagnosis and the evaluation of the therapy efficacy.

Adult↗
PubMed1983

[Use of disc electrophoresis in a linear gradient of polyacrylamide gel concentrations for simultaneous fractionation of total serum proteins, haptoglobins and lipoproteins].

Conditions are developed for fractionation of total proteins of blood serum and lipoproteids within a linear gradient of the polyacrylamide gel concentration. Optimal separation of the proteins was observed at initial concentrations of acrylamide 3 and 10%: lipoproteids--2 and 15%. The composition of haptoglobins should be taken into consideration when analyzing the spectrum of human serum proteins. For this purpose samples fractionated simultaneously in one gel plate should be subjected to differential staining with amide black and benzidine. It is established that the efficiency of alpha-lipoproteids subfractions separation is reached by electrophoresis of this class lipoproteids after polyethylene glycol precipitation. The method described broadens essentially potentialities of electrophoretic fractionation of blood serum proteins due to an increase in the resolving power and sensitivity.

Adult↗