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Biomedical subjects

G Kenny

Publications and source records attributed to G Kenny.

30 records · Page 2Linked to original sources
PubMed1977

Co-operation across histocompatibility differences. The role of inhibitory T cells in preventing successful T-B interaction.

The efficiency of interaction of helper T cells with memory B cells of varying histocompatibility types has been studied in an in vitro microculture system. Such studies show that I-A region matching does not necessarily determine that efficient co-operation will take place. Failure to co-operate under circumstances where T and B cells match in I-A can be attributed to radiosensitive suppressor T cells. The nature of the gene differences which provoke the activity of such suppressor cells have also been examined, and it would seem that even single S.D. differences in the MHC are sufficient to generate 'suppressor' T-cell activity.

Animals↗
PubMed1976

Morphology, morphometry and electron microscopy of HeLa cells infected with bovine Mycoplasma.

The host-parasite relationship of HeLa M cells artificially infected with a bovine species of Mycoplasma was studied by light microscopy, transmission electron microscopy and scanning electron microscopy. The use of morphometry to quantitate some of the findings was explored. The parasites were seen in locations extracellular to the cell surface. The detection of small numbers of organisms by light microscopy was well demonstrated by use of the flurescent antibody technique. Scanning electron microscopy proved to be an excellent method for revealing the surface details of cell-parasite morphology. Ultra-thin sections showed that the parasites are aligned mostly parallel to the plasma membrane of the host cell but separated by a gap of 10nm. Morphometry indicated an average of 69 organisms per cell surface occupying 1.7% of the surface area. An increase of 26% in diameter of the HeLa cells, possibly as a result of infection, was observed.

Biometry↗
PubMed1975

Prevalence of Mycoplasma hominis and Ureaplasma urealyticum (T strains) in urine of adolescents.

Adolescent children were surveyed for colonization with Mycoplasma hominis and Ureaplasma urealyticum by culturing urine specimens. Rates were compared between three study groups: (i) 397 children attending parochial schools, (ii) 293 children attending an adolescent clinic specializing in adjustment problems, and (iii) 86 children attending a renal clinic. The recovery rate was higher among postpubertal girls attending the renal clinic (33%) and the adolescent clinic (26%) than among students attending parochial high school (males 2%, females 8%). Girls had approximately eightfold higher rates than boys of the same age. Isolation of Mycoplasmataceae was associated with certain sociological determinants, such as dating, cigarette smoking, and coming from a broken home, but also with abnormal findings (protein, leucocytes) in urine.

Adolescent↗
PubMedDate not supplied

An ethical investigation into the provision of pain relief in infants.

This article examines issues relating to the pain experienced by infants and the nursing care they receive in the context of universal ethical principles. The intention is to show that ethics is not a remote intellectual pursuit but has the potential to directly affect and enhance the care given to infants in pain. The author maintains that the consequence of using an ethical approach is that the relationship between infant and carer is infused with improved communication and greater self-awareness.

Communication↗
PubMedDate not supplied

Assessing children's spirituality: what is the way forward?

This article identifies the difficulties facing nurses working with the spiritual experiences of children. There is a lack of literature and education available in this field and as a consequence paediatric nurses are forced to use adult-based research. The benefits, as well as the drawbacks of this approach, are examined. In doing so it is hoped that the article might generate debate and discussion as to how to address this valued but under-investigated area of nursing practice.

Child↗
PubMedDate not supplied

Computer-assisted continuous infusion for the delivery of target-controlled infusions of propofol during outpatient surgery.

Propofol was administered intravenously using a first-order, three-compartment, computer-controlled infusion pump (CCIP) based on the Ohmeda 9000 syringe pump. The CCIP system produced a target-controlled infusion (TCI) based on the estimated blood concentration (EBC). Twenty-five patients undergoing ambulatory surgery completed the study. The induction EBC was 4.72 +/- 0.28 micrograms/ml, and was achieved rapidly with minimal hemodynamic changes. The emergence EBC was 1.55 +/- 0.21 micrograms/ml, and the discharge EBC was 1.06 +/- 0.22 micrograms/ml. The EBC, together with clinical signs, allowed for predictable inductance and emergence from anesthesia using propofol.

Adolescent↗
PubMedDate not supplied

Comparison of prostate specific membrane antigen, and prostate specific antigen levels in prostatic cancer patients.

PSA (prostate specific antigen) and PSMA (prostate specific membrane antigen) serum levels were determined in over 235 prostate cancer patients from 8 different United States clinical urological cancer centers. The clinical data were not known until after the serum assay results were shared with all participants to attempt to eliminate possible clinical bias. PSA values are useful in the clinical diagnosis and staging of prostate cancer patients, and generally fall to low values in response to effective treatment, e.g., surgery, hormones, radiation, chemotherapy. PSMA values are not related to clinical stage but if elevated can fall in response to effective treatments. In contrast, PSMA values can be elevated post-treatment in the presence of very low PSA levels (0.01 to 0.00). The elevated PSMA levels predicted a state of clinical progression or clinical resistance in most cases (> 70%). PSMA levels in this study were of better prognostic value than PSA.

Antigens, Neoplasm↗