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Biomedical subjects

G Keiser

Publications and source records attributed to G Keiser.

At least 19 recordsLinked to original sources
PubMed1996

[Candidiasis of the liver following successful chemotherapy of acute myeloid leukemia (Fab type 6) and recovery with oral fluconazole therapy].

The spectrum of disseminated candidiasis includes both an acute and chronic presentation. In contrast to the acute form, chronic disseminated candidiasis (hepatosplenic candidiasis) often occurs late after granulocytopenic episodes in patients undergoing chemotherapy, usually for acute leukemia. We discuss a female patient who underwent extensive successful chemotherapy for acute myelogenous leukemia (FAB type 6) and who developed chronic hepatosplenic candidiasis 19 months later. Therapy with amphotericin B and flucytosine was not successful and a cure was effected only after long-term oral fluconazole treatment. Diagnostic problems, possible reasons for the observed failure of amphotericin B treatment, and the current use of fluconazole in disseminated candidiasis are discussed.

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PubMed1993

[Left ventricular arrhythmogenic dysplasia].

The present rare case study of left ventricular dysplasia attempts to improve understanding of the clinical picture of arrhythmogenic right ventricular dysplasia (ARVD), based on additional facts concerning this clinical picture which has been increasingly diagnosed over the last few years in the investigation of sudden death in adolescents.

Adult↗
PubMed1979

[2 cases of multiple myeloma with osteosclerosis].

A report on two patients with osteoclerotic myeloma is presented (myeloma with osteoblastic lesions). In case one, metastatic bone tumor of unknown origin was wrongly diagnosed initially. Because of increasing neurological symptoms laminectomy was performed. Biopsy led to the correct diagnosis of multiple myeloma of IgA-type. Patient also had a very severe peripheral neuropathy. The second patient had pancytopenia and osteosclerotic lesions of the pelvis. Bone marrow aspiration revealed so-called "empty marrow". Based on these findings, myelofibrosis was wrongly diagnosed at another hospital. Bone marrow aspiration, paper- and immunoelectrophoresis subsequently produced the correct diagnosis of multiple myeloma of IgG-type. Multiple myeloma usually is characterized by osteolytic lesions of the bones. However, the literature contains some 50 cases with osteosclerotic multiple myeloma, three different forms of which are described. In a fairly large percentage osteosclerotic multiple myeloma is combined with periphereal polyneuropathy. It would appear that in IgE-myeloma the incidence of sclerotic lesions is higher. Osteosclerotic multiple myeloma is very rare. It should however be considered if the differential diagnosis of osteosclerotic bone lesions is established.

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PubMed1977

[Congestive, hypertropic cardiomyopathy--intermediary form of primary myocardial disease? (author's transl)].

A 43-year-old woman with anginal pain and the electrocardiographic signs of an old anterior infarction presented the clinical, hemodynamic and angiographic findings of congestive cardiomyopathy. Left ventricular (LV) end-diastolic volume was sizably increased, there was generalized hypokinetic wall motion and LV ejection fraction was reduced to 40 percent. The subsequent clinical course was characterized by progressive congestive heart failure and the patient died 4 years after the first appearance of symptoms. Autopsy revealed marked dilatation of all heart chambers and severe hypertrophy of the LV anterior wall. The LV posterior wall and the septum were less markedly hypertrophied. Light and electron microscopy showed the typical findings of hypertrophic cardiomyopathy in the anterior part of the LV wall whereas the septum and the LV posterior wall presented unspecific histological alterations. In conclusions, this case demonstrates that a clinically typical congestive cardiomyopathy may be associated with a localized area characteristic for hypertrophic cardiomyopathy. Thus it is a postulated that the described patient represents an intermediary form of primary myocardial disease.

Adult↗
PubMed1976

[Primary extranodal lymphogranulomatosis of the flexura dodenal-jejunalis].

A primary extranodal lymphogranuloma of Hodgkin was found in the small bowel (PS II AE) of a 34-year-old man. Two years after radical surgery followed by local telecobalt therapy, the patient is in good health. The symptomatology, therapy and prognosis of this rare form of Hodgkin's lymphogranuloma are briefly reviewed.

Adult↗
PubMed1975

[Plasmocytoma, alkylating agents, and acute myeloid leukemia (author's transl)].

Two cases of the development of acute myeloid leukemia (AML) after treatment with alkylating agents are reported. In Case 1, melphalan and then cyclophosphamide had been given for multiple myeloma. 46 months after onset of cytostatic treatment AML occurred, as confirmed cytochemically and by qualitative determination of urinary lysozyme. In Case 2, cyclophosphamide had been given for rheumatoid arthritis. After a latency of 34 months 'smouldering leukaemia' developed with an atypical monocytic leukaemic cell population. In a third case, multiple myeloma and monocytic leukaemia developed synchronously. The causative role of melphalan and cyclophosphamide in the development of AML seems securely established. Despite the risk of alkylating agents in the treatment of multiple myeloma or Hodgkin's disease causing AML, they should not be replaced, as other drugs have been shown to be less beneficial. On the other hand, alkylating agents should be used with great caution in the treatment of non-malignant diseases.

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