[Autoradiographic and histological findings in vulvar carcinoma during local bleomycin therapy].
Explore the source record for details and available documents.
Administration, Topical↗
Biomedical subjects
G Keil
Publications and source records attributed to G Keil.
Studies on protein-phosphorylation reactions in isolated chromatin.
The endogenous protein-phosphorylating activity of isolated chromatin was tested. We have found that a group of high-molecular-weight proteins (Mr greater than 50 000) was preferentially phosphorylated when chromatin from mouse ascites cells or from bovine lymphocytes was incubated in the presence of ATP. After disintegration of chromatin by nuclease treatment or by high salt concentration, a larger spectrum of chromatin proteins becomes accessible for phosphorylation by the chromatin-bound protein kinase. Some observations described in this communication may help to partially explain this result. The protein kinase was not found in nucleosomal subunits, indicating a non-random distribution of the enzyme in chromatin. This suggests that enzyme and substrate have to be in close spatial contact for the phosphorylation reaction to occur. Furthermore, we have shown for one protein, histone H1, that phosphorylation sites for the endogenous protein kinase are available on the free but not on the DNA-bound protein, suggesting that phosphate-accepting sites in chromatin proteins may be blocked by protein-DNA or by protein-protein interactions. We also discuss the possibility that chromatin protein kinase occurs in stable complexes with its phosphate-accepting substrates, as has been suggested by the findings of other [Kish, V.M. & Kleinsmith, L.J. (1974) J. Biol. Chem. 249, 750-760].
Animals↗
[The five meddle-Dutch translations of "Antidotarium Nicolai". Studies on the professional pharmaceutical literature of medieval Netherlands].
Explore the source record for details and available documents.
Documentation↗
[Five Middle-Dutch translations of the "Antidotarium Nicolai". Studies on the pharmaceutic literature of medieval Netherlands].
Explore the source record for details and available documents.
Antidotes↗
[Criticism of Galen by Rhazes. Valuation of the authority criticism in the Islamic middle ages].
Explore the source record for details and available documents.
History, Medieval↗
[Experiences with Ovosiston in marital and sexual counseling in a district hospital in the period Jan. 1, 1967-Dec. 31, 1968].
Explore the source record for details and available documents.
Adolescent↗
[Contribution on simultaneous pregnancy].
Explore the source record for details and available documents.
Abortion, Therapeutic↗
[Myoma and pregnancy--a case report].
Explore the source record for details and available documents.
Adult↗
[The "costelic laxatijf" of master Peter van Dordt. Investigation on simple-sheet incunabula on drugs of the late middle ages].
Explore the source record for details and available documents.
Germany↗
[The late-medieval health care theory of "Herr Arnoldus von Mumpelier"].
Explore the source record for details and available documents.
Health Education↗
[On the area of usage of Gabriel von Lebenstein's "burnt waters"].
Explore the source record for details and available documents.
Alcoholic Beverages↗