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Biomedical subjects

G Kaur

Publications and source records attributed to G Kaur.

At least 109 records · Page 6Linked to original sources
PubMed1987

Changes in hexokinase isoenzymes in regions of rat brain during thyroid deficiency.

In this work, activities of hexokinase isoenzymes Type I and Type II were measured in the soluble and particulate fractions from the brain regions (cerebral hemispheres (cerebrum), cerebellum and brain stem) of the thyroidectomized adult rats as well as of the thyroidectomized rats administered with triiodothyronine. Thyroidectomy generally decreased the hexokinase activity associated with particulate and soluble fractions. Hexokinase Type II isoenzyme was more affected than the Type I isoenzyme. Administration of triiodothyronine to the hypothyroid rats abolished the effect of thyroidectomy. Adult brain enzymes have been generally considered not be affected by thyroid hormones. The data obtained in this work are suggestive of an effect of thyroid hormones on hexokinase in the adult brain. Since the effects of thyroidectomy on the energy metabolism of the heart tissue are well known, the heart tissue was also studied for comparison.

Animals↗
PubMed1985

Metabolic activity of lysosomes in tin-intoxicated regenerating rat liver.

The metabolic activity of lysosomes was monitored by assaying the lysosomal enzymes. DNase, RNase, acid phosphatase and cathepsin in rat liver regenerating after partial hepatectomy at various intervals after the operation. Results of the present study demonstrate that the activities of lysosomal enzymes are increased significantly during the process of rapid regeneration, especially at 24 h and 48 h. A small rise in enzymatic activities was noticed at 36 and 72 h of regeneration, leading towards normalisation at 168 h. Administration of tin(II) tartrate (25 mu mol Sn2+/100 gm body wt.) significantly increased the DNAse and RNAse activity at 24 h of the regeneration, while a decrease was noticed in acid phosphatase activity. An increase was also found in the catheptic activity of tin-treated hepatectomized rats. It can thus be concluded that an increased metabolic activity of lysosomes is reflected by the increased activity of its hydrolytic enzymes during the regeneration, and tin at low concentrations is helpful to this process. Further work is in progress to gain insight into the other metabolic activity of the lysosomes during the process of regeneration.

Acid Phosphatase↗
PubMed1984

Influence of polyaminocarboxylic acids on the removal of manganese-54 from the body organs of sham-operated and partially hepatectomized rats.

EDTA, 1,2-cyclohexylenediamine tetra-acetic acid (CDTA), hexamethylene 1,6-diamine N,N,N',N'-tetra-acetic acid (HDTA), diethylene-triamine pentaacetic acid (DTPA) and nitrilotriacetic acid (NTA) were examined for the removal of manganese-54(54Mn) from some organs of sham-operated and partially hepatectomized rats in early manganese (Mn) poisoning. CDTA was found to be most effective in removing 54Mn from the liver of both sham-operated and hepatectomized rats. These chelating agents also lowered the Mn levels in kidney, spleen and brain of poisoned rats. Although a significantly higher accumulation of Mn was observed in hepatectomized rats, there was no significant difference in the efficiency of the chelating agents in removing Mn from the body organs of poisoned animals of both the sham-operated and hepatectomized groups. An attempt has been made to seek a possible correlation between % removal of Mn by various polyaminocarboxylic acids and their corresponding stability constants.

Animals↗
PubMed1983

Changes in hexokinase isoenzymes in regions of rat brain during insulin-induced hypoglycemia.

Activities of hexokinase isoenzymes were determined during insulin-induced hypoglycemia in soluble and total particulate fractions from three regions of rat brain. Type I hexokinase isoenzyme activity showed a small decrease in both soluble and particulate fractions from the cerebral hemispheres. In cerebellum and brain stem, however, Type I isoenzyme showed a decrease only in the soluble fraction. A significant increase was observed in hexokinase Type II isoenzyme from both the fractions, in all the three brain regions 1 h after insulin administration.

Animals↗
PubMed1982

The effect of cadmium and manganese on the distribution of iron-59 in partially-hepatectomized rats.

The distribution of iron-59 in blood at various time intervals was studied in sham and partially-hepatectomized rats after a single intravenous injection of 59Fe (III) citrate. A significant difference was observed in the rate of disappearance and reappearance of iron-59 in circulation. Administration of cadmium and manganese at a concentration of 0.5 and 2 mg/kg b.wt., respectively, did not cause any significant change in this pattern. A significant decrease in iron-59 incorporation in the liver of hepatectomized rat was produced by cadmium while manganese had no effect.

Animals↗
PubMed1982

Haem and drug-metabolizing enzymes in regenerating rat liver.

Various parameters of haem and drug metabolism were measured during the course of liver regeneration after two-thirds hepatectomy. Partial hepatectomy produced a significant depression in delta-ALA synthetase and delta-ALA dehydratase, and induction in haem oxygenase at an early stage of regeneration. The values returned to normal within 7-14 days. These changes were also accompanied by a marked decline in benzo(a)pyrene hydroxylase and aminopyrene demethylase. The level of glutathione and the activity of glutathione reductase also increased during the early stage of proliferation. The increased level of glutathione with concomitant decrease in drug-metabolizing enzymes and induction in haem oxygenase could be considered as a protective mechanism for the detoxication process, although a contribution from other biotransforming mechanisms cannot be excluded.

5-Aminolevulinate Synthetase↗