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Biomedical subjects

G Kauert

Publications and source records attributed to G Kauert.

34 records · Page 2Linked to original sources
PubMed1987

Concentrations of mustard gas [bis(2-chloroethyl)sulfide] in the tissues of a victim of a vesicant exposure.

An Iranian soldier died at a toxicological intensive care unit at Munich seven days after a vesicant exposure. At the autopsy the typical symptoms of mustard gas intoxication were found. The vesicant was detected qualitatively by gas chromatography-mass spectrometry (GC-MS) in the abdominal fat and quantified in the tissues and in the body fluids by the following method: (1) extraction by dichloromethane, (2) cleanup of the extracts by thin-layer chromatography (TLC) on silica plates, (3) extractive derivatization with gold-chloride, and (4) quantitative determination by electrothermal atomic absorption spectrometry (ET-AAS). The equal extracts, after heating, served for blanks. The following concentrations were found (milligrams of mustard gas/kilograms of tissue wet weight): brain 10.7, cerebrospinal fluid 1.9, liver 2.4, kidney 5.6; spleen 1.5, lung 0.8, muscle 3.9, fat 15.1, skin 8.4, skin with subcutaneous fatty tissue 11.8, liquid from a skin blister: below detection limit, blood 1.1, and urine: below detection limit.

Adult↗
PubMed1985

Cadmium body burden of an occupationally non burdened population in southern Bavaria (FRG).

The cadmium body burden of the occupationally non-burdened population in the southern Bavarian area was estimated from the cadmium concentrations in liver and renal cortex, determined by ET-AAS of 263 autopsy cases. A mean value of 17.9 mg cadmium was calculated for all cases and 21.9 mg cadmium for all adults. The body burdens found do not depend on sex but greatly on smoking habits. Mean values for non-smokers are 13.5 mg, for moderate smokers 22.5 mg and for heavy smokers 33.2 mg. The dependence on age is similar to that of the cadmium concentration in the kidney cortex: an increase up to an age of approximately 50 years and a decrease at higher ages. Between the average value we found and the critical body burden calculated by Roels et al. (1983) is a safety factor of 8 to 10, but in some of our cases of middle-aged, heavy smokers this safety factor drops to a value lower than 1. It is concluded that it seems to be imperative to control the further trend of the cadmium body burden in occupationally non-burdened populations.

Adolescent↗
PubMed1980

[Investigations of guaifenesine metabolism with gas chromatography-mass spectrometry].

Recently the authors about toxicological investigations after uptake of guaiacol glyceryl ether containing drugs. There had been detected two intensive pink spots on the TLC from urine samples after detection with Marquis-reagent. It is reported about the identification of Catechol glyceryl ether and Hydroxyguaifenesine via Gas Chromatography Mass Spectrometry. Until today only the oxidation of guaiacol glyceryl ether to beta-(2-methoxyphenoxy)lactic acid is described. The demethylation of G. is performed by O-Demethylase localized in liver microsomes. This enzyme seems to be the main enzyme for the metabolism of G. It is pointed out to a pharmacologically interesting relationship between the chemical structure of guaiacol glyceryl ether and codeine.

Gas Chromatography-Mass Spectrometry↗
PubMed1979

[Significance of hydrocyanic acid formation during fires].

Cyanide concentrations of blood samples from fire victims autopsied in the Institute of Legal Medicine, Munich, have been determined. In 25% of 48 analyzed cases cyanide concentrations from 0.52 microgram to 6.24 microgram Cyanide/ml blood have been detected. These results are compared to former studies and the higher mean level in our collective is emphasized. The importance of hydrocyanid acid in the toxicity of fire gases is evidently greater, than assumed. Hydrocyanic acid may be produced from nitrogen continaing polymers during combustion. The quote of these polymers in clothing, furniture, and also in equipment of cars is increasing. Therefore, it is necessary to take more notice of the formation of hydrocyanic acid during combustion, even though carbon monoxide is in general the main toxic agent in fire gases.

Autopsy↗
PubMedDate not supplied

[Death in homes for the aged/nursing homes from the legal medicine viewpoint].

Following the death of 16 inhabitants of a nursing home within a period of 2 weeks, the prosecution ordered legal autopsies in all of the cases, which had not yet been buried or cremated, suspecting a neglect of nursing or active euthanasia respectively. Two out of a total of ten cases revealed drug overdoses which could have explained death. However, due to concurring causes of death, the evidence could not be furnished with adequate security. In the present case, the examinations helped--already in a preliminary stage of the investigations--to prevent the authorities from more expensive proceedings as well as the respective nursing home from being unjustly suspected of having committed a criminal offense.

Aged↗