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Biomedical subjects

G Katona

Publications and source records attributed to G Katona.

45 records · Page 3Linked to original sources
PubMed1976

Objective methods to assess the anti-inflammatory activity of antirheumatic compounds.

A review is to be made of the methods currently being used in the assessment of anti-inflammatory compounds in man. Many of the current methods suffer from the disadvantage of being subjective or depend on various outside factors. We will review methods such as arthroscopy, histopathology, electron microscopy, joint scintigraphy and enzyme determinations in synovial fluid. Arthroscopy will be described in detail and its application to the course of the disease and the effect of anti-inflammatory drugs. Joint scintigraphy using radioactive technetium and indium will be described, which we find easy and reproducible. Current work using such parameters as skin temperature and enzyme content of synovial fluid will be described.

Anti-Inflammatory Agents↗
PubMed1975

Clinical and objective assessments of naproxen through 5 years of clinical experience.

D-2-(6'-Methoxy-2'-naphthyl)-propionic acid (naproxen) is a relatively well-known non-hormonal anti-inflammatory agent useful for long-term usage. The efficacy of naproxen in controlling the signs and symptoms of rheumatoid arthritis had been uniformly demonstrated in an extensive series of international double-blind trials lasting from a few weeks to four months. This paper deals with our experience with naproxen after 5 1/2 years of continuous usage. During this period of time ten different studies were conducted at the Rheumatology Departments of the General Hospital, Mexico City. The efficacy and tolerance of naproxen have been studied in the following indications: rheumatoid arthritis, osteoarthritis, acute and chronic gout and non-articular rheumatism. In these studies the usual clinical methods were used and some special objective methods were utilized in some others, for example, enzymology, scintigraphy, histopathology and arthroscopy. Some of these studies were comparative ones vs. some other well-known non-steroidal anti-inflammatory compounds such as aspirin, indometacin and ibuprofen. During the last 5 1/2 years 877 patients with different theumatic conditions were treated and observed in our Department and in the private practice. In 365 patients with rheumatoid arthritis excellent results were obtained in 34%, good in 36%, fair in 24% and negative in only 6%. In 358 patients with osteoarthritis excellent results were obtained in 28.2%, good in 46.6%, fair in 20% and negative in 5.3%. In 15 patients with acute gout using naproxen as exclusive therapy, excellent results were observed in nine patients very good in four, and unsatisfactory in only two cases. In 35 patients with chronic gout excellent results were observed in 22, good in 11 and negative in two. 93 patients out of the 877 studied since June 1969 used naproxen continuously as anti-rheumatic therapy for more than one year; 33 for more than two years; four patients for more than three years and five of the patients in a few days will complete 5 1/2 years. The side effects of the compound observed during this long period of time in these 877 patients on the g.i. tract, CNS, etc., although present in a limited number of cases (in less than 10% of total number of patients) were definitely less than those observed usually during anti-inflammatory therapy.

Adolescent↗
PubMed1971

[Not Available].

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Forensic Medicine↗
PubMedDate not supplied

Comparison between cytochemical changes, concentration of PAS-positive substances in peripheral blood lymphocytes and changes of blood glucose values during the oral glucose tolerance test.

The purpose of the study was to analyse the correlation between the blood glucose values and the quantity of PAS-positive substances in lymphocytes observed in different groups of subjects during oral glucose loading. In 300 subjects--100 persons with a normal OGTT, 100 pregnant women (with normal, borderline and diabetic OGTT), 50 diabetic patients, 20 borderline cases of diabetes, and 30 persons with a 'lag form' OGIT--the PAS-index was measured at each point of the OGTT. The values of the PAS-index curve followed the values of the blood glucose level, and the results obtained in different groups of persons were compared. It has been shown that an increased value of the PAS-index is an early sign of disturbed carbohydrate metabolism and that differences between borderline and manifest diabetics, as well as between these groups and normal control persons, are significant.

Blood Glucose↗
PubMedDate not supplied

The cytologic identification and quantification of testicular cell subtypes. Reproducibility and relation to histologic findings in the diagnosis of male infertility.

In testicular imprint smears from 100 infertile men (both testicles), stained using the Pappenheim and Papanicolaou methods, the cell forms (light and dark spermatogonia, primary and secondary spermatocytes, spermatids, spermatozoa and Sertoli cells) were identified and quantified by the counting of 500 consecutive cells. Identification of the cell types, which are described and illustrated, was consistent and reproducible; the advantages of the different stainings in their analysis is documented. The cell counts were tested for reproducibility and compared to the histologic diagnoses and sperm counts. Statistical analysis showed the highest reproducibility for cells frequently encountered in smears (0.99 for Sertoli cells and 0.98 for spermatozoa) and the lowest but still satisfactory reproducibility for rare or arbitrarily defined cell forms (0.71 for dark spermatogonia and 0.76 for secondary spermatocytes). The high reproducibility of the smear quantification permits the introduction of a number of indices, defining clinically useful relations between cell types that are indicative of various types of infertility. The data obtained by cytologic quantification showed reasonably good correlation with the histologic diagnoses of desquamation and focal fibrosis and excellent correlation with Sertoli cells only, arrested spermatogenesis and complete fibrosis. The cytologic quantification of testicular smears adds considerable information to the diagnosis of impaired fertility and should be instituted in properly equipped centers.

Cell Count↗