G Karanikas — Page 2 | Search PubMed

PubMed1995

Radiation-induced vascular damage.

A 55-year-old male underwent detailed angiological and biochemical investigation because his daughter suffered from myocardial infarction in the 29th gestational week. An inborn familial plasma factor defect and increased Lp(a) were detected. Localized vascular changes were found in the right femoral artery while the resting vascular system was normal. Anamnestic data revealed a testicular cancer and therapeutic irradiation in that area (5000 rad) 12 years ago.

Biological Factors↗

PubMedDate not supplied

Technetium-99m-tetrofosmin: a new agent for melanoma imaging?

The aim of our study was to examine whether technetium-99m 1,2-bis[bis(2-ethoxyethyl) phosphino]ethane (tetrofosmin) a lipophilic, cationic tracer which was first developed for myocardial perfusion imaging, could be a new radiopharmaceutical for melanoma imaging. We therefore used two human cell lines, SK-MEL 28 and 5i8 A2 (n = 6, cell concentration 106/ml, incubation at 22 degrees C and 37 degrees C, 50-100 approximately lCi/ml Tc-99m-tetrofosmin, time of incubation 10-180 minutes). The cellular uptake by both cell lines was determined. In contrast to another non- melanoma tumor cell line MCF-7 (a human adenocarcinoma breast cancer) which reached steadystate almost immediately (within 10 minutes), the cellular uptake of SK-MEL-28 increased after 60 minutes and showed a very high uptake (> 10%) after 120 minutes and decreased after 180 minutes (6-8%), while the uptake in 518 A2 cells was about 5% after 90 minutes. Our data show that Tc-99m-tetrofosmin could be a promising agent for melanoma imaging.

Biological Transport↗