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Biomedical subjects

G Kaplan

Publications and source records attributed to G Kaplan.

At least 307 records · Page 17Linked to original sources
PubMed1978

Difference in the effect of immobilized ligands on the Fc and C3 receptors of mouse peritoneal macrophages in vitro.

The function of the Fc and C3 receptors on the free surface of normal and endotoxin activated mouse peritoneal macrophages seeded on glass bound antibody--antigen (AbAg) complexes or complement was examined. We found that the glass bound AbAg complexes interfered with attachment and internalization of particles recognized by the Fc receptor. The C3 receptor function in these cells was not affected. On the other hand, normal and activated macrophages seeded on glass bound complement showed no change in the function of the C3 and the Fc receptors.

Animals↗
PubMed1978

[Juvenile arthritis reevaluated in rheumatology in adult age. 30 cases].

The authors describe and comment on 30 observations of peripheral polyarthritis starting before puberty and reveluated in an adult rheumatologoy service at the average age of 29 and during an observation period of about 16 years. The actual classification of juvenile polyarthritis proves to be valid in this group since the clinical forms are still observed in adulthood. However, during the evolution, there is a shifting from one form to another. The systemic forms can reoccur in adulthood even after several years of quiescence, accompanied by visceral complications. The pauciarticular forms as a rule remain benign. As in childhood, they frequently show antinuclear factors. Some forms, initially peripheral, can show axial signs. The presence of HLA B27 antigens allow them to be linked up with ankylosing spondylarthritis. But this is not the case for all the forms with sacroiliac functions. The evolution since childhood is often characterized by long remissions which can still persist by the time of the visit, which is then motivated by resulting mechanical and local arthrotic problems. Despite often severe anatomical symptoms, the functional handicap is limited, allowing quite a remarkable adaptation. Most of the patients lead an active professional life. Yet despite this and despite an often satisfactory sex life, half of the patients have a psychological handicap which makes it necessary for them to be placed under special carl. No therapeutic conclusion, particularly about the efficiency of the basic therapy, can be drawn from this study.

Adult↗
PubMed1977

The morphology of echinoid phagocytes and mouse peritoneal macrophages during phagocytosis in vitro.

The morphology of mouse peritoneal macrophages and echinoid phagocytes during phagocytosis in vitro was studied. A striking similarity in the function of the foreign surface receptor is found in the two systems. Glutaraldehyde-treated erythrocytes attached randomly over the entire surface of the cells and were internalized without circumferential attachment between the particles and the phagocyte membrane. The particles seemed to sink directly into the cytoplasm of the cells. Tannin-treated erythrocytes were phagocytosed by the echinoid cells in a similar mode. The complement-coated erythrocytes were attached only in the perinuclear area of the echinoid phagocyte's membrane, but the morphology of their internalization was similar to that mediated by the foreign surface receptor. A circumferential attachment between the particles and the phagocyte membrane did not seem necessary. This is also the case for mouse peritoneal macrophages.

Animals↗
PubMed1977

Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages.

Mouse macrophages, activated in vivo or in vitro, were made to internalize sheep erythrocytes opsonized with IgG or IgM and complement. Scanning electron microscopy and transmission electron microscopy were performed at various times after the transfer of the cultures from conditions favoring attachment to conditions favoring internalization. The receptors for Fc and C3 were distributed randomly over the macrophage surface with the exception of the extreme periphery, were Fc receptors were more abundant. The E-IgG were ingested by means of thin membrane extensions rising from the macrophage surface and enclosing the opsonized particles tightly in a cup-like structure protruding from the macrophage surface. Only afterwards were the covered particles drawn into the cell body proper. The E-IgMC were seen to sink directly into the macrophage cytoplasm without apparent involvement of membrane extensions. Experiments with cytochalasin B suggested that microfilaments were essential for the phagocytosis by Fc but much less important with the C3 receptor.

Animals↗
PubMed1976

Idiopathic ureterolithiasis in a renal transplant patient.

Only 9 cases of ureteral stone formation in renal transplant recipients have been reported previously. The majority of these occurred in association with hyperparathyroidism. We herein describe a case in which a ureteral calculus caused partial obstruction within 3 months in a euparathyroid recipient of a living related renal transplant.

Adult↗
PubMed1976

Management of fifth metatarsal head lesions by biplane osteotomy.

We have been using monoplane and biplane wedge osteotomies in the management of fifth metatarsal head lesions and have revised the procedure presented by Sgarlato, Subotnick and Gerbert in that we have been utilizing distal diaphyseal dorsiflexory adductory wedge osteotomies as well as proximal diaphyseal dorsiflexory adductory wedge osteotomies. We feel that the neck wedge osteotomy offers the advantage of reduced postoperative diability and correction of pathology.

Bone Diseases↗
PubMed1975

Immunosuppression in vitro induced by leukemia virus-infected splenocytes (38544).

Immunization of dispersed spleen cells from normal mice in vitro with SRBC was suppressed by simultaneous incubation of the spleen cell cultures with splenocytes from mice previously infected with FLV. Cell-free virus preparations alone did not suppress the antibody response. In contrast, relatively small numbers of splenocytes from infected mice, even when present at a ratio of 1-500 normal spleen cells, significantly suppressed the in vitro immune response to SRBC. Viable leukemic splenocytes were necessary for immunosuppression although the leukemic cells did not have to be in direct contact with the normal spleen cells. Specific anti-FLV serum, when added to the leukemic splenocytes or to normal spleen cells separated from infected cells by cell-impermeable membranes, prevented immunodepression.

Animals↗