Biomedical subjects
G Kanny
Publications and source records attributed to G Kanny.
Prevention by monovalent haptens of IgE-dependent leucocyte histamine release to muscle relaxants.
The cross-reactivity between muscle relaxants (MRs) is a risk for inducing anaphylaxis in sensitized patients. The preventive use of monovalent haptens (MHs) was studied in 21 cases. Inhibition of the skin reactivity by mixing MRs and MHs was observed, as was the inhibition of leucocyte histamine release to MRs, up to 3 h after infusion of MHs. These results argue for the use of such a protocol, if surgery requires the use of a MR in patients at risk for anaphylaxis.
Delayed adverse reaction to sodium ioxaglic acid-meglumine.
A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine.
Immunochemical analysis of peritoneal dialysate in a patient with hypersensitivity to icodextrin.
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[Food allergies].
Food allergy gathers the bulk of pathologies linked to the immuno-allergic response to various foods. It is most often due to an IgE-dependent mechanism. Food allergy may be expressed by various clinical pictures: atopic dermatitis, asthma, anaphylactic shock, urticaria. Its actual incidence is probably underestimated. Diagnosis rests on logical and rigorous advance of thought based on history, physical examination and dietary inquiries. Skin prick-tests constitute the choice method for searching sensitization towards food allergens. Biological assays directed towards specific IgE are second-intention tests. Oral provocation tests constitute the gold standard for establishing the role of a food in the appearance of symptoms. They should be conducted under close medical supervision. Eviction-reintroduction methods represent a heavy diagnostic approach, with rare indications at the present time. The strictness of the methodology used by the allergologist is essential for establishing the diagnosis of food allergy.