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Biomedical subjects

G Jullien

Publications and source records attributed to G Jullien.

36 records · Page 2Linked to original sources
PubMed1975

Erythrocyte 2,3-diphosphoglycerate as related to diabetes and obesity.

2,3-Diphosphoglycerate was determined in the erythrocytes of 17 diabetic and 18 obese patients. Results for obese subjects were significantly (P less than .01) different from those obtained for 21 healthy subjects. Results for obese and diabetic patients also differed significantly (P less than .01) but not those for diabetic and healthy subjects. Hemoglobin, hematocrit, or bicarbonate measurements did not differ among the three groups.

Adolescent↗
PubMed1975

[Propranolol and arterial hypertension: study with frequent daily checking of blood pressure and serum levels after 1 week of treatment].

In order to establish correlations between serum levels of Propranolol, blood pressure in hypertensive patients and cardiac rate, these parameters have been recorded at three different times in a day and after a week. This study points out that therapeutic response is variable. However the patients may be classified into 4 groups. This classification and the value of serum levels of propranolol are discussed.

Blood Pressure↗
PubMedDate not supplied

Non-linear kinetics of ethanol elimination in man: medico-legal applications of the terminal concentration-time data analysis.

Research regarding parameters suitable for reporting on the activity of enzymatic systems responsible for ethanol metabolism is of obvious interest in medico-legal practice. Blood ethanol concentration-time curves, following oral administration of ethanol, have been developed for ethylic and non-ethylic subjects. This study has confirmed the non-linear kinetics of ethanol elimination; however, existing non-linear models appear to be inadequate for usual medico-legal practice, because of their complexity. We observed three phases during the elimination of ethanol. The first order terminal phase is characterized by its half-life. This parameter seems adequate as a basis for determining the activity of enzyme systems responsible for the metabolism of ethanol.

Adult↗
PubMedDate not supplied

Evolution of plasma acetate concentration during ethanol metabolism in man.

Following oral administration of ethanol to ethylic as well as non-ethylic volunteers, the entire time course of plasma acetate concentration has been observed. The curve shows a typical evolution in three phases: (1) a quick ascending phase (2) a steady state characterized by a mean concentration (-C) (3) a first-order decrease, characterized by its half-life (t1/2) These parameters show significant variations (increase of -C, decrease of t1/2) in the ethylic subjects, in comparison with the non-ethylic ones. The variation of the area under the acetate curve according to the dose of ethanol given, is linear. The comparison of such a development with the one, typically non-linear, of the area under ethanol curve previously analyzed for the same subjects, may guess the origin of the non-linearity of ethanol kinetics.

Acetates↗