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Biomedical subjects

G Jorge

Publications and source records attributed to G Jorge.

3 recordsLinked to original sources

High magnetic field studies of the hidden order transition in URu2Si2.

We studied in detail the low temperature/high magnetic field phases of URu2Si2 single crystals with specific heat, magnetocaloric effect, and magnetoresistance in magnetic fields up to 45 T. Data obtained down to 0.5 K, and extrapolated to T=0, show a suppression of the hidden-order phase at H0(0)=35.9+/-0.35 T and the appearance of a new phase for magnetic fields in excess of H1(0)=36.1+/-0.35 T observed only at temperatures lower than 6 K. In turn, complete suppression of this high field state is attained at a critical magnetic field H2(0)=39.7+/-0.35 T. No phase transitions are observed above 40 T. We discuss our results in the context of itinerant versus localized f electrons.

Journal Article↗

Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia.

We report a chronic myeloid leukemia patient without evidence of a Philadelphia (Ph) chromosome in whom RT-PCR analysis performed in blast crisis demonstrated the existence of both common b3a2 and b2a2 BCR/ABL fusion transcripts. In situ hybridization studies with BCR- and ABL-specific probes showed location of the BCR/ABL fusion gene on chromosome 9, band q34, instead of at chromosome 22q11, and that it resulted from an insertion of the 5' side of BCR within the ABL gene on chromosome 9. The vast majority of cells showed a BCR/ABL fusion gene on both chromosomes 9, which is equivalent to a double Ph chromosome, thus reinforcing the notion that the critical event in CML is the formation of a functional BCR/ABL fusion gene.

Chromosomes, Human, Pair 9↗