HTLV-I transmission and myelopathy induced by blood transfusion.
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Biomedical subjects
Publications and source records attributed to G Jordan.
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Laparoscopic examination was performed successfully on 14 patients with 17 nonpalpable testes. The procedure was successful in determining the location in 16 of 17 nonpalpable testes, and this information was beneficial for selecting the subsequent operative approach. Laparoscopy was safe in the younger child (10 patients were 3 years old or less and 7 patients were less than 2 years old), and it added an insignificant increase in operative time.
The capacity of Coxsackie B viruses (CBVs) to produce diabetes in mice was studied before and after passage in various cell types. CBVs that had been passaged in monkey kidney cells or in mouse embryo fibroblasts failed to produce abnormal glucose tolerance tests, whereas virus passaged five or more times in the pancreata of mice or in beta-cell cultures produced transient abnormal glucose tolerance tests. Immunofluorescence and histologic studies revealed that passage of CBVs in cultured beta-cells changed the tropism of these viruses from the acinar pancreas to the islets of Langerhans. Although all six CBV serotypes that had been passaged in beta-cell cultures behaved very similarly, substantial variation was observed with the different virus passages and in some experiments, beta-cell damage and the glucose abnormalities were minimal. From these and other experiments, we conclude that the six members of the CBV group have the potential for infecting and damaging pancreatic beta-cells in mice.
From a group of 424 patients with histologically verified fatty liver 92 patients without diabetes mellitus and alcohol abuse were subjected to follow-up examination for 3 1/2 years. 56 patients underwent second liver biopsy at this time; 20 of these patients had shown marked fatty liver at the initial liver biopsy examination. These 20 patients with marked fatty liver and 25 further patients with moderarte fatty liver could be followed up 5 and 7 1/2 years later; the clinical examination, the various liver function tests, liver scan and blind liver biopsy did not show any evidence of progression of fatty liver towards chronic inflammatory liver disorders or precirrhotic states. This clinical study therefore suggests the harmlessness of non-alcoholic fatty liver.
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Bronchial mucosa and bronchial basement membranes of man and of healthy slaughter animals were examined with the scanning electron microscope. The surface relief of the normal human bronchus mucosa is composed of a system of bulge-like prominences and valleys. There are parallel recesses and narrow valleys which run parallel to the longitudinal axis of the bronchus. Man and pig have the same kind of surface relief in bronchus. A fundamental different type of surface area relief is exhibited by the cow and the sheep. The bronchial basement membrane is a homogeneous plate with dune-like prominences and trough-shaped depressions. Often one can see perforations of variable size. The structures of the basement membranes have a great variability and no species-specifity. There are the same types of dysplasias in the bronchus mucosa in man and in animals. The differences are based upon in the wideness of the expansion and in the grade of the dysplasias in man.
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