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Biomedical subjects

G Jones

Publications and source records attributed to G Jones.

624 records · Page 35Linked to original sources
PubMedDate not supplied

Why should anyone be led by you?

We all know that leaders need vision and energy, but after an exhaustive review of the most influential theories on leadership--as well as workshops with thousands of leaders and aspiring leaders--the authors learned that great leaders also share four unexpected qualities. The first quality of exceptional leaders is that they selectively reveal their weaknesses (weaknesses, not fatal flaws). Doing so lets employees see that they are approachable. It builds an atmosphere of trust and helps galvanize commitment. The second quality of inspirational leaders is their heavy reliance on intuition to gauge the appropriate timing and course of their actions. Such leaders are good "situation sensors"--they can sense what's going on without having things spelled out for them. Managing employees with "tough empathy" is the third quality of exceptional leadership. Tough empathy means giving people what they need, not what they want. Leaders must empathize passionately and realistically with employees, care intensely about the work they do, and be straightforward with them. The fourth quality of top-notch leaders is that they capitalize on their differences. They use what's unique about themselves to create a social distance and to signal separateness, which in turn motivates employees to perform better. All four qualities are necessary for inspirational leadership, but they cannot be used mechanically; they must be mixed and matched to meet the demands of particular situations. Most important, however, is that the qualities encourage authenticity among leaders. To be a true leader, the authors advise, "Be yourself--more--with skill."

Administrative Personnel↗
PubMedDate not supplied

Central venous catheters for infusion therapy in gastrointestinal cancer. A comparative study of tunnelled centrally placed catheters and peripherally inserted central catheters.

Protracted venous infusion of 5-fluorouracil (5-FU) is a common treatment for patients with gastrointestinal malignancy. A central venous access device is required for safe and effective drug delivery. This study uses a survival analysis to compare the useful life and treatment completion success of tunelled centrally placed catheters (TCPCs) and peripherally inserted central catheters (PICCs). It also describes complications found with both devices. Data on insertion, complications, and removal of TCPCs and PICCs were collected on standardized forms, prospectively for initial PICCs and retrospectively for initial TCPCs. Survival of indwelling catheters was similar for both devices for the first 120 days, but after that TCPC survival was statistically better than that of PICCs (P = 0.051). Complications occurred in 61% of patients with TCPCs and 67% of patients with PICCs. The authors conclude that PICCs provide less invasive, more cost-effective, and easier to schedule central venous access for 5-FU infusion; however, their advantage over TCPCs decreases significantly in treatments lasting more than 120 days.

Antimetabolites, Antineoplastic↗
PubMedDate not supplied

Recombinant leukocyte alpha interferon in advanced ovarian carcinoma.

Recombinant leukocyte alpha interferon (rIFN-alpha A; Hoffmann-La Roche, Inc) was administered to 15 patients with recurrent or persistent ovarian carcinoma. All patients had been previously treated with surgery and combination chemotherapy including cyclophosphamide (15 patients), doxorubicin (14), and cisplatin (14). Three patient had also previously undergone radiation therapy. At the start of therapy the largest tumor size was less than or equal to 2 cm in four patients and greater than 2 cm in 11. Interferon was administered in three times weekly for 8 weeks at a dose of 20 X 10(6) units/m2, with average drug levels of 2267 pg/ml 6 hours after im injection. In three patients (20%), the dose had to be reduced by 50% because of drug toxicity. Side effects included fever (greater than 101 degrees F) in 12 patients, fatigue in ten, headache in two, diarrhea in two, and reversible myelosuppression in five. Of the 15 patients, one had mixed response lasting 12 weeks, two had stable disease of 8 weeks' duration, and 12 had disease progression.

Adenocarcinoma↗
PubMedDate not supplied

Two immunogenic peptide conjugates derived from P. falciparum MSA2 give rise to antibodies that crossreact with a nonhomologous 195-kDa malarial protein.

Merzoite Surface Antigen 2 (MSA2) is a 51-kDa antigen from P. falciparum that has marked sequence variation between malarial strains but contains highly conserved N- and C-terminal sequences. Previously described peptide sequences from these conserved domains are capable, when coupled to the carrier protein diphtheria toxoid (DT), of raising antibodies that recognize MSA2 in a number of malarial isolates. In this study we report the existence of two peptide conjugates from the conserved C-terminus of MSA2 which, when used as immunogens, produce antibodies that react with a 195-kDa protein and give a merzoite surface pattern on immunofluorescence assay (IFA). The antisera against these peptide conjugates do not recognize MSA2; however, the 195-kDa protein, and identical surface pattern on IFA, is recognized by a monoclonal antibody (mAB) against Merzoite Surface Antigen 1 (MSA1). These two peptides, when unconjugated to DT, are nonimmunogenic, and DT alone is not capable of inducing antibodies that react with malarial proteins. The combination of the carrier and either peptide is capable, however, of raising antibodies against MSA1, despite sharing no sequence homology with this antigen. This data thus highlights the importance of protein conformation when generating antibody against carrier-peptide conjugates.

Amino Acid Sequence↗
PubMedDate not supplied

Minor injury care in the community.

This article describes the setting up and running of a nurse-led, community-based, minor injuries unit. Initially meeting with resistance from the local health authority, a six month pilot study showed that the clinic could operate effectively to the benefit of the community. The process of setting up the clinic and the type of service it provides are described.

Community Health Nursing↗
PubMedDate not supplied

Ways of reducing the waiting times for patients in A&E.

This paper reflects the current debate surrounding the Patient's Charter standard for initial assessment within the A&E department and suggests ways of improving the quality of the assessment and reducing waiting times for patients in A&E.

Emergency Service, Hospital↗