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G Jondeau

Publications and source records attributed to G Jondeau.

77 records · Page 5Linked to original sources
PubMed1983

Is dopamine a physiological natriuretic hormone in the dog?

Both plasma and urinary dopamine and noradrenaline were measured as free and sulphate conjugates, by a radioenzymatic method, before and during extracellular volume expansion (ECVE) with hypo-, iso- or hyper-tonic fluid (usually sodium chloride solution) in dogs. During ECVE there was a decrease in plasma catecholamine concentration. For all cases except noradrenaline, this is probably due to a dilution phenomenon since when results were expressed as pg/mg of protein, ECVE had no effect. This change in noradrenaline accounted for the increase in the dopamine/noradrenaline ratio. As expected, there was an increase in the urinary excretion of dopamine during ECVE with both iso- and hyper-tonic fluid. This increase was not observed in the group of dogs given hypotonic fluid, although the increase of fractional excretion of sodium was of a similar order of magnitude. The increase in the urinary excretion of dopamine was apparently not affected by an increase in plasma sodium concentration and/or osmolality. The demonstrated dissociation between sodium and dopamine in urine does not support a physiological role for dopamine in renal handling of sodium during ECVE, and raises the question of its specificity.

Animals↗
PubMedDate not supplied

[Non-radioimmunometric NT-ProBNP and BNP assays: impact of diluent, age, gender, BMI].

We examined the analytical correlation between non-radioimmunometric plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) and evaluated whether NT-proBNP or BNP was influenced by age, gender and/or body mass index (BMI). Electro-chemiluminescence (Elecsys, Roche diagnostic) and a single use fluorescence (Triage, Biosite) immunoassays were used to measure NT-proBNP and BNP levels respectively. As a preliminary, seven different diluents usually used in immunoassays were tested and the "speciality diluent" (Ortho Clinical Diagnostic) was validated to increase the linearity of BNP immunoassay above 5000 pg/mL. Data were collected prospectively from patients admitted to the emergency department for acute dyspnea. Plasma BNP and NT-proBNP were measured at admission. Reference diagnosis was adjudicated by 2 independent cardiologists using the European Society of Cardiology guidelines. One hundred and sixty consecutive patients were included: 84 females and 76 males, mean age 80.1 +/- 13.5 (16-98). The analytical correlation between NT-proBNP and BNP was satisfactory using the equation: log10(NT-proBNP) = 1.1xlog10(BNP) + 0.57 and a correlation r = 0.93. This was established over a wide range of concentration (5-6400 pg/mL for BNP). Age and gender were known to influence circulating BNP levels. We showed that the correlation between BNP and NT-proBNP was not influenced by age, gender and body mass index of patients which suggests that the distribution of both peptides was similarly affected by these parameters. We conclude that NT-proBNP, as assayed in the present study, correlates closely with BNP. Used in conjunction with other clinical information, rapid measurement of BNP or NT-proBNP is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.

Adolescent↗
PubMedDate not supplied

Management of heart failure in the elderly: recommendations from the French Society of Cardiology (SFC) and the French Society of Gerontology and Geriatrics (SFGG).

Heart failure, a frequent disease in the elderly, has a pejorative prognosis. Clinical diagnosis is complicated by atypical or difficult-to-interpret symptoms and by the concomitant presence of other diseases, particularly cognitive impairment, neurological disorders and diseases of the musculoskeletal system. Among the additional investigations, echocardiography remains underused. Impairment of diastolic left ventricular function is frequent. The usual laboratory tests must include calculation of the creatinine clearance, which is indispensable for dosage adjustment of certain drugs (ACE inhibitors, digoxin, spironolactone). The value of plasma natriuretic peptide assays as diagnostic tools has not been determined in elderly or very elderly populations and the plasma B-type natriuretic peptide increases with age. Comprehensive geriatric assessment is essential in order to screen for concomitant diseases and determine the patient's degree of dependence. The general objectives of treatment remain applicable to the elderly subject: improvement in the quality of life, reduction of mortality and the number and duration of hospitalisations, and slowing disease progression. In the frail elderly subject, symptom alleviation is to be the primary objective. In the absence of specific studies on elderly or very elderly subjects, most of the recommendations have been extrapolated from the data based on the evidence generated in younger populations. The dietary rules are to be more flexible than those used for younger subjects, particularly in order to prevent the risk of denutrition induced by strict salt-free diets. Special precautions for the use of heart failure drugs are due to comorbidities and the pharmacokinetic and pharmacodynamic changes related to aging. Drugs dosage increase is to be cautious and carefully monitored for adverse reactions. The therapeutic programmes in which multidisciplinary teams are involved reduce the number and duration of hospitalisations and the costs generated by the disease.

Aged↗