Biomedical subjects
G Jaffé
Publications and source records attributed to G Jaffé.
A multicentric clinical trial comparing Otocerol with Cerumol as cerumenolytics.
Fifteen general practitioners conducted a randomized, double-blind comparative trial of two cerumenolytics, namely, Otocerol and Cerumol. A total of 106 patients were entered into the study (fifty-three in each group). Otocerol was shown to be marginally better than Cerumol in all parameters evaluated.
A comparison of lomotil and imodium in acute non-specific diarrhoea.
A multicentre trial was conducted to compare Lomotil and Imodium in the treatment of acute non-specific diarrhoea in general practice. A total of eighty-three patients contributed to the study and were randomly allocated to one of the two treatments. No statistically significant differences were found betwwen the drugs in their efficacy and speed of action in alleviating diarrhoea or in their palliative effect on nausea/vomiting and abdominal pain when present.
A double-blind, multi-centre comparison of naproxen and indomethacin in acute musculo-skeletal disorders.
A double-blind, multi-centre trial was carried out in 191 patients with acute musculoskeletal conditions to compare the efficacy of naproxen and indomethacin. Patients were randomly allocated to receive either 250 mg naproxen or 50 mg indomethacin twice daily. Treatment was for 7 or 14 days. The results, assessed by the patients' subjective responses, showed that statistically significant improvements in pain, mobility and general condition were produced by both drugs from the first day of treatment. Improvement continued throughout the treatment period but there was no significant difference in the degree or rate between the two drug groups. Twenty-seven patients (13 on naproxen; 14 on indomethacin) withdrew from the study because of side-effects.
A comparative study of talampicillin and ampicillin in general practice.
Talampicillin hydrochloride, the phthalidyl ester of ampicillin, when given in a dosage containing the equivalent of 125 mg of ampicillin four times daily for six days to general practice patients, has proved to be as effective, both clinically and bacteriologically, as 250 mg of ampicillin given four times daily for six days. Although the over-all incidence of side-effects was similar with both preparations, diarrhoea was significantly reduced in talampicillin-treated patients. Possible reasons for this are discussed. Talampicillin therefore offers certain advantages over ampicillin in producing effectiveness equivalent to that of ampicillin at a lower dosage level with a reduced incidence of diarrhoea.