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Biomedical subjects

G Jacob

Publications and source records attributed to G Jacob.

At least 91 records · Page 5Linked to original sources
PubMed1985

Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine. A case report of treatment with intra-arterial urokinase and review.

A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery. Treatment was started with heparin and vasodilators. Benefit from this was limited and a course of intra-arterial urokinase was instituted. This gave almost total resolution of the injury. The mechanisms producing ischaemia following intra-arterial injection of drugs of abuse and possible treatment are discussed.

Accidents↗
PubMed1985

Treatment of oesophageal perforation by intubation.

The mortality following oesophageal perforation ranges from 25% to 100% depending on the delay in diagnosis and treatment. Although the treatment recommended for thoracic perforations is emergency thoracotomy and suture of the perforation, the avoidance of this approach in elderly patients is desirable. We therefore describe 6 cases of oesophageal perforation which were treated by insertion of a Celestin tube at laparotomy.

Aged↗
PubMed1984

A comparison of cryodestruction with excision or infarction of an implanted tumor in rat liver.

In this study a malignant tumor was implanted in rat livers and treated by infarction, excision, or cryodestruction. Survival and the pattern of metastases was studied in each group. Walker carcinomas were induced by the inoculation of a tumor cell suspension into the livers of male Sprague-Dawley rats. Ten days after inoculation a solitary tumor had formed. This was treated by (i) mobilization of the tumor-bearing lobe (controls); (ii) ischemic infarction by ligation of the vascular pedicle to the lobe; (iii) excision of the tumor-bearing lobe; or (iv) cryodestruction of the tumor and surrounding liver using a clinical liquid nitrogen probe. A double freeze/thaw cycle to - 180 degrees C at a mean cooling rate of 94 degrees C/min was performed. Autopsy was performed at death or after 110 days, when the experiment was terminated. In general, deaths within 5 weeks of treatment were from recurrent tumor growth in the liver and, after this time, from metastatic disease. A statistically significant increase in survival was noted in the cryotherapy group when compared with the other treatment groups (P less than 0.01 logrank ) and controls (P less than 0.001 logrank ). No real difference in local tumor control was noted between the groups. The improved survival in the cryotherapy group was attributed to a statistically significant reduction in deaths from metastatic disease (P less than 0.05 Chi-square). This finding may be related to an immunological response and warrants further study.

Animals↗
PubMed1984

Prevention of post-appendicectomy sepsis by mezlocillin and metronidazole: a prospective, randomized, double-blind trial.

In a double-blind trial a 6% infection rate resulted from the use of a single peroperative dose of mezlocillin in emergency appendicectomy for non-perforated disease. No advantage was demonstrated by mezlocillin over the 8% infection rate achieved with metronidazole. There was only one anaerobic infection in the mezlocillin group although Bacteroides fragilis had been isolated at operation from all three infected cases and many other uninfected patients. No anaerobic infections were detected in the metronidazole group.

Adolescent↗
PubMed1980

Influence of histone phosphorylation upon histone-histone interactions studied in vitro.

Histones H2b and H3, phosphorylated in vitro with the catalytic subunit of protein kinase I from rabbit skeletal muscle, were used to estimate the influence of histone phosphorylation upon histone-histone complex formation. Stoichiometry and interaction affinity of the complexes H2a-H2b, H4-H2b, and H4-H3 were determined by using the continuous variation method based on circular dichorism or fluorescence intensity. All complexes exhibit a 1:1 stoichiometry in sodium phosphate or sodium chloride solution of pH 7.0. The association constants of the complexes containing phosphorylated H2b were only slightly reduced, whereas that with phosphorylated H3 was strongly reduced relative to those of the nonphosphorylated species.

Animals↗
PubMed1975

[Asbestos as an envoronmental carcinogen (author's transl)].

Relations between asbestosis and bronchial carcinoma and also since a long time for diffuse malignant pelural and peritoneal mesothelioma have been ascertained for professional exposure to asbestos. On the other hand such relations can be proved statistically for non-professional environmental influence only with malignant serosa tumors. Their increased occurrence goes parallel to the hyaline (calcified) pleura-plaques, to another professional and non-professional consequence of asbestos dust inhalations. There is not enough evidence to accuse asbestos to be a carcinogen causing also other malignomas. It is sure, the number of uncontrolled persons, occupationally or nonoccupationally exposed to asbestos, is still very high. Nevertheless no increased risk of cancer, provoked by asbestos can be supposed for the public at present. For selected population groups, however, increased occurence of mesothelioma cannot be denied, at least in the past. Favorable Favorable conditions exist for the solution of problems still unsolved in asbestosis control, due to the registration of all persons exposed to asbestos dust, and due to the commitment of notifying all tumors.

Asbestos↗