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Biomedical subjects

G J Royle

Publications and source records attributed to G J Royle.

4 recordsLinked to original sources

X-ray scatter signatures for normal and neoplastic breast tissues.

Measurements of breast tissue scattering properties have been made in an energy dispersive x-ray diffraction system over the momentum transfer range of 0.70 to 3.50 nm(-1). One hundred samples of excised tissue have been used. Results from the diffraction system have been compared with the histological analysis for each individual sample. It has been found that tissue types can be characterized on the basis of the shape of the scatter spectrum and on its relative intensity. The shapes are significantly different between tissue types in the range 1.0 to 1.8 nm(-1) and suggest that if particular values of momentum transfer are monitored, a discriminating signal could be obtained. Analysis of the maximum intensity in the signature also reveals a change of up to a factor of 2 between adipose and fat-free tissues.

Adolescent↗

Quantitative x-ray diffraction analysis of bone and marrow volumes in excised femoral head samples.

The aim of this paper is to apply the technique of quantitative x-ray diffraction analysis (QXDA) to trabecular bone tissue to demonstrate that quantitative data of the ratio of bone and marrow volumes within the trabecular region can be obtained. Apparatus has been constructed for measuring energy dispersive x-ray diffraction spectra of human femoral head samples in the diagnostic x-ray energy range. Individual diffraction peaks due to bone and marrow tissue were identified in the measured spectra. The relative intensities of the two peaks within the spectra quantify the relative proportions of the two components, and so the bone to marrow peak ratio is proposed as a parameter which is capable of providing information on the osteoporotic state of trabecular tissue. Preliminary results indicate a significant correlation between this method and the bone density measurement techniques of quantitative computed tomography and Compton scatter densitometry. Results have shown that the use of a synthetically prepared calibration curve can enable absolute measurement of bone or marrow volumes.

Bone Marrow↗