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Biomedical subjects

G J Maletta

Publications and source records attributed to G J Maletta.

29 records · Page 2Linked to original sources
PubMed1982

Progressive supranuclear palsy.

Progressive supranuclear palsy has been recognized as a distinct nosological entity for about three decades now. Typically, this progressive neurological disease manifests itself late in the sixth decade with a terminal course of approximately four to six years. Well over one hundred cases have been described in the literature and the heterogeneous nature of progressive supranuclear palsy includes the characteristic vertical ophthalmoplegia, frequent falling and a profound nuchal rigidity. Other features are similar in many respects to those found in Parkinson's disease. The present article reviews the literature on progressive supranuclear palsy with particular reference to its clinical manifestations including the ophthalmoplegia, characteristic sleep disturbances and unique dementia. Also addressed, are neuropathological and epidemiological findings. Finally, conclusions and recommendations for further investigation are offered especially with regard to the neuropsychological nature of this neurological disorder.

Brain↗
PubMedDate not supplied

Commentary on review by Veith and Raskind: the many faces of depression.

A range of different dysphoric symptomologies are subsumed under the general diagnostic label of depression. This may lead to problems with inter-laboratory reliability when reporting results of depression research. A partial list of a variety of "unhappiness" is submitted to encourage rigor of definitions and to stimulate discussion. Comments are made concerning the difficulty in drawing definitive conclusions about the possible influence of normal aging on CNS disturbances underlying depression. Also, the need is reinforced for in vivo baseline studies of the human nervous system as well as for creative experimentation using a variety of species. Finally, a plea is made for more openness and cooperation in the neurosciences regarding research activities and findings.

Aged↗