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Biomedical subjects

G J Jesmok

Publications and source records attributed to G J Jesmok.

25 records · Page 2Linked to original sources
PubMed1978

Transmural triglycerides in acute myocardial ischaemia.

The effect of coronary artery occlusion on endogenous triglycerides of left ventricular subepicardium and subendocardium was studied in the open-chest anaesthetised dog. Under control conditions, the subepicardium was found to have a greater concentration of triglycerides than the subendocardium. Thirty minutes after acute coronary artery occlusion there was a decrease followed by a steady increase at 60, 120, and 240 min in subepicardial triglycerides of the ischaemic region. No change in triglycerides in the subendocardium of normal or ischaemic regions was observed. The initial decrease of subepicardial triglycerides in the ischaemic region was blocked by administration of propranolol or bevantolol (CI-775; a specific beta 1 antagonist) given 30 min before occlusion. It is concluded that the effect of coronary artery ligation on transmural endogenous triglycerides is biphasic with an initial period of increased mobilisation followed by a period of increased deposition.

Animals↗
PubMed1977

The effect of inotropic agents on glycerol release and protein kinase activity ratios in the isolated perfused rat heart.

Glycerol release was employed as an index of endogenous glyceride hydrolysis in rat hearts perfused by a Langendorff technique with Krebs-Henseleit-bicarbonate buffer containing 5.5 mM glucose. Changes in cardiac contractility induced by glucagon, isoproterenol, epinephrine and ouabain were associated with an increase in glycerol efflux from the heart in a dose-dependent fashion. Propranolol, a beta adrenergic blocking agent, markedly diminished the increase in glycerol release due to isoproterenol without affecting this same parameter subsequent to glucagon or ouabain infusion. Insulin, a potent antilipolytic agent in adipose tissue failed to diminish glycerol efflux elicited by any of the inotropic agents studied. Protein kinase activity ratios were employed as an index of cyclic adenosine 3':5'-monosphate levels. Increases in cardiac contractility and glycerol efflux induced by isoproterenol and glucagon were associated with increases in protein kinase activity ratios while increases in contractility and glycerol efflux induced by ouabain were not accompanied by an increase in protein kinase activity ratios.

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PubMedDate not supplied

Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction.

Acute myocardial infarction was produced in anesthetized dogs by ligation of the left anterior descendens coronary artery. Propranolol (2 mg/kg i.v.) administered 4 hours post ligation was examined for its ability to reduce infarct size estimated by histochemical and enzymatic methods. There was a signficant correlation between these two methods in their estimation of infarct size. Treatment with propranolol significantly decreased infarct size estimated with both methods. It is concluded that some portion of the myocardium can be protected against infarction by pharmacologic intervention as late as 4 hours after the onset of coronary artery occlusion.

Animals↗
PubMedDate not supplied

Fat emulsion catabolism in vitro and in vivo--sex related differences.

The removal rates of an intravenously administered 10% fat emulsion (Intralipid) from plasma in male and female conscious rats are described. The plasma concentration of fat emulsion particles at various time intervals following a bolus administration (0.2 g/kg) was measured by nephelometry. At the dose employed, the removal of fat emulsion from the plasma followed first order kinetics, ie, a constant fraction was removed from the plasma per unit of time, K2 (%/min). Females exhibited a significantly greater fractional removal rate (K2) than comparably aged males (21.0 +/- 1.0 vs 15.0 +/- 1.4, p less than 0.05). Postheparin lipoprotein lipase, measured using fat emulsion as substrate, also was significantly greater in female rats compared with males. Our results demonstrate that, in rats, fat emulsion (Intralipid) is catabolized more rapidly in females than in males and a greater lipoprotein lipase activity in female rats may be the causative factor.

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