A climate which is not the most favorable. Appendix A. 1976 presidential address.
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Ethics, Medical↗
Biomedical subjects
G J Carroll
Publications and source records attributed to G J Carroll.
Drug addiction among physicians. The Virginia experience.
Drug addiction among physicians appears to be an occupational hazard, with chronic pain, depression, and the easy availability of drugs major factors leading to addiction. In this study of 46 cases of physician addicts handled by the Virginia State Board of Medicine, meperidine hydrochloride (Demerol) was the most frequent addictive agent. The Virginia disciplinary and therapeutic plan for addicted physicians was effective in successfully rehabilitating and returning to medical practice 72% of the 46 physician addicts reported to the board from 1949 to 1974.
Adult↗
Peripheral cardiovascular effects in rats after central administration of histamine and antihistamines.
1. Vascularly isolated but nervously intact rat right hind limbs were perfused with blood at a constant flow rate and changes in perfusion pressure (proportional to vascular resistance), heart rate and blood pressure were monitored. 2. Histamine administered into the right lateral cerebral ventricle (i.c.v.) through guide cannulae, induced dose-dependent increases in perfusion pressure, heart rate and blood pressure. 3. Prior i.c.v. or i.v. administration of metiamide (an H2-antagonist) did not prevent the cardiovascular responses to i.c.v. histamine but rather prolonged them. Following i.c.v. or i.v. administration of chlorpheniramine (an H1-antagonist), however, changes in vascular resistance, heart rate and blood pressure were not significant. 4. Metiamide administration appeared to have some agonist activity on its own. Thus the role of H2-receptors in cardiovascular responses to centrally administered histamine remains unclear. 5. The work shows that in rats increases in nervous dishcarge to at least the hind limb vascular bed occur following central administration of histamine and conforms that increases occur in heart rate and blood pressure. These responses appear likely to be mediated through stimulation of central H1-receptors.
Animals↗
Monoarthropathy. Could this be infection?
BACKGROUND: Monoarthritis in an adult presents a diagnostic challenge. Monoarticular symptoms usually imply local joint pathology, but may be a referred phenomenon, a feature of a periarticular syndrome such as a stress fracture or the dominant manifestation in polyarticular disease. OBJECTIVE: When confronted with an acute or subacute monoarthritis, exclusion of sepsis is essential and wherever feasible joint aspiration and diagnostic analysis of synovial fluid should be undertaken. DISCUSSION: A history of joint stiffness, restricted joint movements and the presence of an effusion are generally helpful indicators of true arthritis. Synovial fluid examination is the single most informative investigation that can be performed in this clinical setting. It should include a total and differential leucocyte count, scrutiny for crystals under polarized light and microscopy and culture for organisms. In the absence of organisms or crystals, the presence or absence of blood in the aspirate and the number and type of leucocytes will assist in the differentiation of other diagnostic possibilities.
Adult↗