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Biomedical subjects

G J Carmichael

Publications and source records attributed to G J Carmichael.

4 recordsLinked to original sources

A modification to enable controlled progressive advancement of the Twin Block appliance.

A modification of the Twin block appliance has been developed to facilitate controlled gradual advancement of the mandibular position during the treatment of Class II division I malocclusions. This features the incorporation of stainless steel screws with conical heads into the blocks of the upper appliance to provide the inclined plane effect. Advancement is by the addition of polyacetal spacers between the screw heads and the upper blocks. The system is designed to improve the clinical flexibility of the appliance and to enhance patient acceptance in cases where mandibular protrusion is limited initially. Another possible application is gradual reactivation for Class III correction. Other advantages are reduced laboratory and clinical time during reactivation of the appliance, and perhaps a more physiological response to the growth modification process. The design and construction of the advancement system is illustrated, and its clinical use discussed.

Humans↗

Influence of dihydrotestosterone on sex determination in channel catfish and blue catfish: period of developmental sensitivity.

Treatment of channel catfish with 0.2, 20, or 200 mg/liter of dihydrotestosterone (DHT) in the water during the egg stage or during egg and sac-fry stages did not alter the expected 1:1 sex ratio of the progeny. Feeding DHT at 200 mg/kg of feed for the first 21 days after yolk sac absorption resulted in 80% females; this proportion was increased by combining feeding with treatment of 200 mg DHT/liter in the sac-fry stage (90%) or in the egg and sac-fry stage (97%). In contrast, treatment of blue catfish sac-fry with 200 mg DHT/liter, with or without the combination of feeding DHT at 200 mg/kg food, resulted in 100% female populations. Neither clomiphene citrate, an estrogen-receptor blocking agent, nor clofibrate, an inhibitor of hepatic synthesis of cholesterol, affected the sex ratio of channel catfish, and neither of these compounds altered the feminizing effect of 200 mg DHT/kg when fed in combination with DHT. The nonaromatizable androgen DHT is not as effective as many other androgens in producing paradoxical female populations of channel catfish. However, feminization of blue catfish by treatment of sac-fry indicates that this species is more susceptible to hormonal manipulation and that the period of sex determination may occur earlier in development than in channel catfish.

Animals↗