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Biomedical subjects

G J Becker

Publications and source records attributed to G J Becker.

At least 199 records · Page 11Linked to original sources
PubMed1981

Monoclonal antibodies to human macrophage and leucocyte common antigens.

Three monoclonal antibodies have been made to identify cells of the human mononuclear phagocyte system in fluids and tissues. The first, PHM 1, recognises a surface antigen common to all leucocytes. The other 2 antibodies, PHM 2 and PHM 3, bind to monocytes and macrophages but not to polymorphonuclear cells (PMN). PHM 2 labels all monocytes, macrophages and a small population of T-cells. PHM 3 labels most monocytes and macrophages but no other blood cells. The application of these monoclonal antibodies to the identification of mononuclear phagocytes in blood and liver using an unlabelled antibody immunoperoxidase (PAP) technique is demonstrated.

Antibodies, Monoclonal↗
PubMed1981

Familial urate nephropathy.

This report describes a family with the rare combination of tophaceous gout and renal failure. We emphasise that asymptomatic hyperuricemia may be associated with significant renal disease and suggest that in addition to tubular atrophy and interstitial fibrosis, both obstructive glomerular and tubular lesions and also vascular lesions are important in the pathogenesis of urate nephropathy. We recommend that potentially affected family members should be actively sought and treated at an early age in the hope of preventing the development of renal failure.

Adolescent↗
PubMed1980

Renal infection with Mycobacterium chelonei.

A case of renal infection with Mycobacterium chelonei is described. The infection probably occurred via haematogenous spread from an infected arteriovenous shunt in a uraemic woman. Prolonged treatment with intravenous cefoxitin combined with oral erythromycin and rifampicin eradicated the organism from the urine. Although renal function stabilised for one year, gradual deterioration to end-stage renal failure occurred.

Adult↗
PubMed1980

Value of serum C-reactive protein measurement in the investigation of fever in systemic lupus erythematosus.

The concentration of C-reactive protein (CRP) in the sera of patients with systemic lupus erythematosus (SLE) was higher when the disease was active than when it was inactive, but was only markedly raised in patients suffering from identifiable microbial infection. CRP levels greater than 60 mg/l suggest the presence of intercurrent infection and may therefore be a valuable aid to the differential diagnosis of pyrexia in SLE.

C-Reactive Protein↗
PubMed1980

Detection of pneumoperitoneum: optimum body position and respiratory phase.

Experimental studies of pneumoperitoneum in left lateral decubitus and erect positions were made in various phases of respiration to evaluate the visibility of small amounts of free intraperitonel air. Films were also made with various positions of the central ray of the x-ray beam. The expiratory left lateral decubitus film nd the mid-inspiratory chest film demonstrated the small pneumoperitoneums best. Both inspiration and expiration chest films are recommended inm the refilming and expiration chest films are recommended in the refilming sequence if a clinically suspected pneumoperitoneum is not visualized initially. In all cases the central ray of the x-ray beam should be at the highest level fo the peritoneal cavity.

Humans↗
PubMed1977

Plasmapheresis in the treatment of glomerulonephritis.

Nine patients with various forms of glomerulonephritis were treated by repeated plasmapheresis which was combined with immunosuppression, and anticoagulant therapy. Improvement in renal function occurred in the seven patients in whom there had been rapid deterioration in renal function. Two patients with gradually deteriorating renal function failed to respond. Plasmapheresis may exert its beneficial effects both by depletion of circulating immune complexes or autoantibodies, and by depletion of important mediators of injury such as fibrinogen and complement.

Adult↗
PubMed1977

Plasmapheresis in Goodpasture's syndrome with renal failure.

Four patients who presented with severe proliferative glomerulonephritis associated with linear deposition of IgG on the basement membrane have been treated by intermittent massive plasmapheresis. Two patients had all the features of Goodpasture's syndrome. In the other two cases, the characteristic renal lesion was present but there was no pulmonary involvement. In all cases, renal function improved after plasmapheresis while in two, renal function deteriorated after plasmapheresis was stopped. On of these patients responded to a second course of plasmapheresis but failed to respond to a third. This study supports previous reports of the value of plasmapheresis in patients with Goodpasture's syndrome and renal failure in whom recovery without plasmapheresis has not been recorded. The present study emphasizes the importance of continuing treatment for a period of weeks to permit prolonged remission. If treatment is withdrawn too early, rapid deterioration in renal function may result, and unless plasmapheresis is recommenced at once the renal failure may then prove irreversible.

Adolescent↗
PubMedDate not supplied

Standard dose Gd-DTPA dynamic MR of renal arteries.

Renal MR contrast enhancement depends on the timing of image acquisition. Limited human trials have demonstrated efficacy of renal artery stents on salvage of renal function. This study assessed the ability of dynamic gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) administration to demonstrate renal artery stenosis and renal stent patency compared to conventional angiography as the gold standard. Twenty subjects referred for renal angiography underwent 22 dynamic MR studies, including 7 with renal artery stenting (Palmaz P204 or P201, Johnson & Johnson, Sydney, Australia). All were examined with conventional angiography and after dynamic Gd-DTPA infusion. Coronal MR images of the kidneys were acquired using a GE Signa 1.5-T magnet (General Electric Medical Systems, Milwaukee, WI) (fast spoiled gradient echo [FSPGR]; TE=4.2 msec, TR=68-150 msec, flip angle=75 degrees) 0 to 600 seconds after iv bolus injection of 15 ml of Gd-DTPA during sequential breath-hold acquisitions, 13 to 32 seconds each. All 51 renal arteries (13 stenosed, 38 normal) were detected with dynamic MRI. Severity of renal artery stenosis was classified correctly with an accuracy of 98% (95% confidence interval [CI]: 85-100), yielding 98% specificity and 100% sensitivity. All nine renal stents were visualized with 100% accurate patency documentation. FSPGR MRI with bolus Gd-DTPA administration can provide adequate time and spatial resolution to demonstrate renal artery stenosis.

Adult↗
PubMedDate not supplied

Percutaneous angioplasty for atherosclerotic renal artery disease: effect on renal function in azotemic patients.

PURPOSE: We studied the effect of percutaneous transluminal renal angioplasty (PTRA) on renal function in azotemic patients with atherosclerotic renal artery stenosis. METHODS: The results of PTRA were analyzed retrospectively in 40 patients. There were 61 stenoses, 54 of which received balloon angioplasty; 7 had stent placement during the initial procedure, 6 for recurrent stenosis 6-18 months after PTRA. RESULTS: Technical success was achieved in 95% of cases. The complication rate was 15%, compared to 6% in nonazotemic patients. Mean creatinine rose from 1.9 +/- 0.15 mg/dl (mean +/- SEM) to 2.4 +/- 0.17 mg/dl during the year before PTRA, stabilizing at 2.5 +/- 0.57 mg/dl for 1 year after PTRA. PTRA was clinically successful in 60% of patients; 40% showed further deterioration of renal function. Clinical failure was associated with residual renal artery stenosis and presence of intermittent claudication. CONCLUSION: We conclude that PTRA helps salvage renal function in patients with azotemia and atherosclerotic renal artery stenosis.

Aged↗
PubMedDate not supplied

Morphologic and clinical results of the transjugular intrahepatic portosystemic stent-shunt (TIPSS).

The concept of transjugular intrahepatic portosystemic stent-assisted shunt (TIPSS) using the Palmaz iliac stent has been successfully accomplished in 18 of 24 patients representing a technical success rate of 75%. Fourteen were male, 4 female with a mean age of 60 years (range 34-84 years). According to classification of Child's and Turcotte, 6 were in stage A, 6 in stage B, and 6 in stage C. Five patients were treated on an emergency basis because of massive active bleeding. In 10 patients the portosystemic tract was created between the middle hepatic vein and the right main stem of the portal vein in 8, and the left main stem in 2 patients. In 8 patients, the shunt was established between the right hepatic vein and the right main branch of the portal vein. The portosystemic gradient in 18 patients was 29.9 +/- 6 mm Hg and dropped to an average of 16.9 +/- 4 mm Hg after shunt establishment. Within the early postprocedural period of 30 days, 1 patient died of direct complications of the procedure. Because of catheter dislocation, embolization of the percutaneous transhepatic approach to the portal vein after successful shunt "creation" could not be done and was followed by intraabdominal exsanguination. One patient died of an ARDS after TIPSS. A third developed pulmonary infection. In 13 patients, because of hematomas at the puncture site of the transhepatic approach, only the transjugular approach was elected for establishing TIPSS.(ABSTRACT TRUNCATED AT 250 WORDS)

Equipment Design↗