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Biomedical subjects

G J Barbero

Publications and source records attributed to G J Barbero.

At least 37 records · Page 2Linked to original sources
PubMed1975

The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.

Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis. The salivary exocrinopathy is characterized by increased amounts of PAS-reactive mucoprotein in the acinar cells and by obstruction and dilatation of ducts by precipitated material with the same staining characteristics as those found in the acinar elements.

Animals↗
PubMed1975

The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.

Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis. Changes included elevated concentrations of Na+, Ca++, protein, and carbohydrate. In addition, this saliva was found to have ciliotoxic properties similar to those of CF serum. The similarities in cilioinhibitory effects salivary composition, and histologic appearance justify the use of the chronically reserpinized rat as a model for cystic fibrosis.

Animals↗