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Biomedical subjects

G J Andersen

Publications and source records attributed to G J Andersen.

44 records · Page 3Linked to original sources
PubMed1980

The roll-over test as a screening procedure for gestational hypertension.

One hundred and ninety-one primigravidae each had 2 roll-over tests between 28 and 34 weeks of gestation. The first identified 21 (44%) and the second 20 (42%) of the 48 women who later became hypertensive. Of the women who remained normotensive, the first test identified 82 (57%) and the second, 78 (54%). Only 10 (21%) of the women who became hypertensive had 2 positive results and only 50 (35%) of those who remained normotensive had 2 negative results. The mean increase in diastolic pressure on moving from the left lateral to the supine position was the same in women who remained normotensive as in those who became hypertensive. The results of the investigation suggest that the roll-over test is not sufficiently reliable, sensitive, or specific for use as a screening test for gestational hypertension in clinical practice.

Blood Pressure↗
PubMed1977

Study of aldosterone levels in plasma during pregnancy.

A method for the estimation of unconjugated aldosterone in the plasma of pregnant women has been developed. The method is suited to routine analysis of a large number of samples, both from pregnant and non-pregnant subjects. An ethyl acetate extract of plasma is oxidized with sodium periodate to destroy interfering lipids and corticosteroids. Aldosterone is quantitatively converted to aldosteroid-gamma-lactone which is estimated by radioimmunoassay. The method has high specificity and an overall recovery of 80 +/- 5%. The method has been used to establish circulating levels of aldosterone during pregnancy and the menstrual cycle. In early pregnancy, levels of aldosterone were 2-3 times higher than in the follicular phase of the menstrual cycle and a further significant rise occurred at the beginning of the third trimester. No correlation could be detected between plasma aldoserone and plasma progesterone, nor between plasma aldosterone and the birth weight of the baby. Plasma aldosterone levels in women who subsequently developed hypertension were no different from those in women who remained normal throughout pregnancy.

Aldosterone↗