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Biomedical subjects

G Ishikawa

Publications and source records attributed to G Ishikawa.

At least 55 records · Page 3Linked to original sources

Sarcomas of the mouth and jaws--a study of 16 autopsy cases.

Sixteen autopsy cases of the primary sarcomas of the mouth and jaws were reviewed, which included 1 chondrosarcoma, 3 osteosarcomas, 1 leiomyosarcoma, 7 rhabdomyosarcomas and 4 histiocytic lymphoma (reticulum cell sarcoma). Although the case materials studied were too small, the pattern of the spread of the sarcomas of the mouth and jaw was likely to be divided into two groups, localized and generalized. The former is comprised of chondrosarcoma osteosarcoma, leiomyosarcoma and pleomorphic rhabdomyosarcoma. The latter is comprised of alveolar rhabdomyosarcoma and histiocytic lymphoma. Embryonal rhabdomyosarcoma belongs to either depending on the case. The former, being resistant to local therapy, tended to recur with a contiguous spread but was slow to metastasize. Metastases were limited to the lung and pleura through the hematogenous route. The primary sarcoma of the latter group were not so extended in local spread and occasionally cured with therapy. However, metastases, both hematogenous and lymphogenous, were generalized.

Adolescent↗

Spindle-cell carcinoma of the oral cavity.

Two autopsy cases are presented of spindle-cell carcinoma of the oral cavity, which were transformations from the pre-existing well differentiated squamous cell carcinoma in Case 1 and verrucous carcinoma in Case 2, after large doses of irradiation. In Case 2, the conventional squamous cell carcinoma existed at the time of biopsy. Our case study suggests that the spindle-cell carcinoma may develop from the verrucous carcinoma by dedifferentiation through the intermediate stage of conventional squamous cell carcinoma.

Carcinoma↗

Fibromatosis of the oral cavity.

Nine cases of fibromatosis occurring in or near the oral cavity are presented here. They are classified as nodular fasciitis (3 cases), aggressive infantile fibromatosis (2 cases), fibrosing myositis (1 case) and fibromatosis (1 case). Of the 5 cases of nodular fasciitis, 3 occurred from the fascia of the masticatory muscle and 2 from the submucous fascia of the palate and tongue. The aggressive infantile fibromatosis showed a prominent infiltrating growth and an alarming histologic appearance. One of the 2 cases showed a recurrence, but the postoperative course of both cases was uneventful for 13 years and 10 years, respectively. The fibrosing myositis is an unusual fibromatosis of the muscle, which arose within the tongue muscle. The lesion was benign and can be cured by conservative surgery.

Adult↗

Benign papillary squamous tumors of the mouth.

Sixty-eight cases of benign papillary squamous tumors of the mouth were reviewed to elucidate further their histopathologic variations, as well as to clarify the premalignant nature of these tumors. The cases were classified into five varieties: idiopathic pseudoepitheliomatous hyperplasia (2 cases), papilloma (55 cases), oral florid papilloma (7 cases), inverted papilloma (3 cases) and recurring oral papillomatosis (1 case). The series included very rare cases, to our knowledge, undescribed in the literature. Though a microscopic differentiation between the benign papillary squamous tumors, verrucous carcinoma and well differentiated squamous cell carcinoma is quite difficult, clinical and pathologic recognition of these tumors is imperative, because of the differences in their clinical course and therapeutic requirement. A definite diagnosis should be made after the clinical and microscopic findings have been carefully correlated. Malignant change occurred in the oral florid papilloma and recurring oral papillomatosis.

Adult↗

Sialadenoma papilliferum: report of case.

A case of sialadenoma papilliferum, which occurred on the hard palate off a 61-year-old man, is reported. The tumor is considered to be a true neoplasm rather than hyperplasia of the duct cells of the salivary gland.

Adenoma↗

Calcifying epithelial odontogenic tumor: histochemical and electron microscopic observations on a case.

A case of calcifying epithelial odontogenic tumor was studied histochemically and electron microscopically. This case was characterized by an abundant amount of homogeneous substance and the presence of numerous clear cells. Although the homogeneous substance was shown to be an amyloid material in nature, it was supposed to be an extracellular product of the epithelial tumor cells. The clear cells contained abundant glycogen granules in their cytoplasm.

Adult↗