[Preparation and clinical use of combined broad spectrum vaginal suppositories].
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Biomedical subjects
Publications and source records attributed to G Illei.
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Polyamine oxidase activity, already shown to be present in maternal serum, was measured in amniotic fluid between 15 and 40 weeks of gestation in 38 samples. The enzyme activity increased as pregnancy progressed, the levels being lower than those found in the maternal serum. Homogenates of chorion, amnion, separately and together, also showed the presence of enzyme activity, the levels being lower than those previously found in the decidua, but substantially higher than those found in the placenta. Ii is suggested that the enzyme found in amniotic fluid might be the consequence of a diffusion from the decidua through the membranes.
Polyamine oxidase activity was measured in different compartments of the feto-maternal unit by a radiochemical method. The activity in the retroplacental serum (mainly of intervillous origin) was 20 to 30 times higher than in maternal uterine or peripheral venous blood sera. No activity was found in the fetal cord blood sera. The enzyme level in the maternal peripheral sera fell to undetectable levels within 72 hours post partum. Preliminary data indicate that the enzyme might be produced by the decidua rather than by the placenta. It is suggested that the enzyme may constitute an important part of a supposed local immunological barrier formed at the placental bed to help to protect the fetal allograft from maternal immune rejection through a local suppressive effect on maternal cellular immunity.
The existence of a spermine oxidizing enzyme was established in human pregnancy serum by a radiochemical method, and a cross-sectional study of its quantitative profile between 10 and 40 weeks gestation was undertaken. Though there was a wide scatter of values, the rise in the average activity was continuous and highly significant. The flavoprotein inhibitor, quinacrin, inhibited the enzyme activity, while the pyridoxal phosphate inhibitor, isoniazid, had no significant inhibitory effect suggesting that the enzyme is of tissue origin. The possible role of polyamines and their oxidation in physiological immunoregulation is discussed.
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The occurrence of first cousin couples was 2.90/00 in Hungary involving three different population samples (about 2,000, 1,000 and 2,000 women after delivery in the capital, two cities, and a city with agricultural characteristics, respectively).
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