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Biomedical subjects

G I Sidorenko

Publications and source records attributed to G I Sidorenko.

At least 19 recordsLinked to original sources
PubMed2004

[Novel functional stress test (stochastic) and perspectives of its application].

AIM: To assess advantages of a stochastic functional stress test during which workloads change according to law of random numbers. METHOD: Results of stochastic tests and standard stress tests with stepwise increments of workloads were compared in 45 healthy subjects and 90 patients with ischemic heart disease (45 with angina pectoris, 45 after myocardial infarction). RESULTS: Compared with standard tests stochastic test was characterized by shorter times of achievement of ischemic threshold and higher double product. Sensitivity and specificity of stochastic test were significantly better than those of standard stress test. The difference between results of two tests can be explained by increased information content of the stochastic test.

Chronic Disease↗
PubMed2004

[Psychoemotional stress tests and prospects for their use in cardiology].

Social and economic transformations of the society enable to suggest an ever increasing role of psychoemotional factors in the development of cardiovascular pathology. The paper contains a review of psychoemotional functional stress tests (arithmetic, speech, information, computer games). Stroop-testing method, which over the recent half of a century has been acknowledged as < >, is described in detail. Criteria for assessment of psychoemotional stress tests, including ECG and blood pressure dynamics, echocardiography, heart rate variability etc., are also described. Method for quantitative evaluation of effectiveness of psychoemotional Stroop-testing from the positions of information theory is suggested. The method is based on correlations between physiological response and flow of information being processed (bit/s).

Blood Pressure↗
PubMed2004

[The problem of optimization in cardiology].

Optimization is understood as choice of the best version out of the competitive decisions. The strategy and tactics of prevention is presented from this point of view. Optimization of diagnostic investigations is viewed from the positions of continuum with quantitative assessment of results. Characteristics of loads and heart activity, as recommendations suggest, should be in agreement in stress tests. Optimization of dynamic investigations of biochemical markers is described on the model of acute coronary syndrome. Optimization of therapy is based on the determination of criteria of optimum. This statement is illustrated by the example of antihypertensive therapy. Optimization of pharmacotherapy must envisage the preservation of favorable effect of protective natural mechanisms in the form of autoregulation and adaptation to intermittent ischemia (preconditioning).

Cardiology↗
PubMed2003

[Some unsolved problems of assessment of blood pressure level].

The paper deals with blood pressure level assessment and selection of individual optimal blood pressure by means of determination of critical frequency of fusion of flashes. The problem of "white coat" and office hypertension as well as encoding of these states in the context of WHO International Classification of Diseases is also discussed.

Blood Pressure↗
PubMed2003

[Neurocirculatory dystonia (does this disease exist?)].

Difficulties of diagnostics of neurocirculatory dystonia are discussed. Definition based on Myasnikov's ideas about hyperreactivity, that is inadequate cardiovascular responses to psychoemotional stress, is proposed. Peculiarities of classification and therapy of neurocirculatory dystonia are presented.

Acrylates↗
PubMed2002

[Modification of clinical classification of heart failure with quantitative evaluation of functional state].

Definite dissociation exists between severity of clinical symptoms of heart failure and degree of cardiac dysfunction. Comparative analysis of existing heart failure classifications reveals low degree of congruence in evaluation of patient's state by different experts. This disagreement is mainly caused by limited number of gradations in NYHA classification and descriptive character of information. That is why supplementation of current classification with quantitative assessment of functional state by means of introduction of precise and easily obtainable statements is required. A modification of 6 min walk test is suggested for this purpose. The paper contains methodology of the test and calculations necessary for assessment of working capacity (in joules) and intensity of work (in watts). Possibility of evaluation of results of cardiovascular surgery is especially stressed.

Disability Evaluation↗
PubMed2002

[The no-reflow phenomenon and its clinical significance].

The no-reflow phenomenon is characterized by inadequate myocardial perfusion without angiographic manifestations of mechanical vascular occlusion. The phenomenon occurs after coronary vascular interventions (coronary angiography, percutaneous coronary angioplasty, stenting, coronary artery bypass surgery). The development of the no-reflow phenomenon significantly worsens clinical evolution of disease increasing the number of cases of congestive heart failure and hospital mortality. Changes of endothelial function and morphology, changes of blood rheology and microvascular autoregulation are important for pathogenesis of the phenomenon. The treatment include intracoronary introduction of verapamil, adenosine, intravenous introduction of activators of KATP channels (nicorandil), inhibitors of glycoprotein IIb/IIIa receptors. The reasons for early preventive use of intracoronary introduction of verapamil and other drugs in the presence of risk of development of no-reflow phenomenon are presented. The interrelationship between no-reflow phenomenon and syndrome X is also stressed.

Adenosine↗
PubMed2002

[Some results and perspectives of heart failure research].

Heart failure is a frequent often in the practice of a cardiologist but data on its actual incidence are inconsistent. This can be explained by variations in methodological approaches. Screening studies require simple easily obtainable and safe techniques capable to characterize activity of a patient. Their results should be compatible with widely accepted NYHA classification. Six minute walking test is one of possible solutions. Its results agree with NYHA classes, peak oxygen consumption and prognosis of survival. For improvement of accuracy of estimation of physical working capacity it is important to consider body mass. This can be achieved by a simple portable device constructed by the authors. To assess sufficiency of circulation during testing it is advisable to determine the load at which decorreleation between dynamics of effort and that of physiological parameters is revealed. Basing on the above considerations the authors suggest to define heart failure as a condition when decorrelation of physiological functions causes deterioration of perfusion and worsening of quality of life.

Heart Failure↗
PubMed1995

[Ecological hygiene--a science of global health].

The paper defines ecological hygiene, a science that combines a preventive trend and comprehensive ecological analysis of man-made changes occurring in the biosphere. Ecological hygiene may be regarded as a science of global human health in relation to ecological situations, of modes of its maintenance, promotion, and improvement. As for its application, ecological hygiene may be determined as a complex of medical preventive research subjects whose purpose is to maintain and promote health by preventing diseases and premature aging. To apply this approach, ecological hygiene studies the environment and its influence on the human body, reveals unfavourable environmental factors and defines the maximum acceptable levels of their influence, works out recommendation how to eliminate unfavourable factors and how to rationally apply useful ones.

Ecology↗