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Biomedical subjects

G I INGRAM

Publications and source records attributed to G I INGRAM.

At least 19 recordsLinked to original sources
PubMed1965

PARTIAL THROMBOPLASTIN TIME TEST WITH KAOLIN. NORMAL RANGE AND MODIFICATIONS FOR THE DIAGNOSIS OF HAEMOPHILIA AND CHRISTMAS DISEASE.

The partial thromboplastin time test provides a convenient and sensitive screening procedure for deficiencies of thromboplastic factors, especially factors VIII and IX. The test is carried out after preincubating the plasma for 10 minutes with kaolin, and Inosithin is used as a platelet substitute. The ;normal range' of the test has been estimated in terms of the differences encountered between random normal plasmas tested in pairs, because individual patients are usually tested against single control subjects. A patient's partial thromboplastin time should be regarded as abnormal if it is more than six seconds longer than the control time. In the diagnosis of haemophilia, patients' plasmas with concentrations of factor VIII as low as about 20% might be regarded as being within the range of normal, if the selected control subject's factor VIII happened to lie near the lower end of the normal range. When mild haemophilia is suspected, discrimination may be improved by diluting both the patient's and the control plasmas 1 in 20 in haemophilic plasma. With the test modified in this way the clotting time is prolonged, though the range of differences among normal subjects is unaltered, and plasmas with factor VIII concentrations below about 30%, i.e., in undiluted plasma, would be unlikely to be regarded as normal. The partial thromboplastin time may be similarly modified as a screening test for factor IX deficiency.Some clinical examples are reported.

Aged↗
PubMed1960

Short-term assessment of red blood cell survival using 51Cr.

(5) Cr techniques for the study of red blood cell survival over long periods in the steady state are now well established (Ebaugh, Emerson, and Ross, 1953; Mollison and Veall, 1955; Hughes Jones and Mollison, 1956). This paper presents the results of an investigation of the validity of a (51)Cr study not exceeding 10 days which is well suited to a combination with a (59)Fe technique for the rapid simultaneous assessment of red cell production and destruction where haematological conditions may show fairly rapid changes.

Chromium↗
PubMed1960

A rapid "side-room" method for the determination of plasma fibrinogen concentration as fibrin.

A method is proposed for the rapid estimation of plasma fibrinogen concentration. The technique depends on the increase of optical density occurring when plasma clots. A kit is described which obviates the use of laboratory apparatus, so that the test may be performed in the ward side-room if a small centrifuge can be provided.A calibration curve has been prepared for use with commercial opacity standards, and a measure of the error of the method has been obtained.

Fibrin↗